2023
DOI: 10.1002/jat.4538
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Investigation of TGF‐α‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates

Kristin Beirow,
Christian Schmidt,
Britta Jürgen
et al.

Abstract: The immortalized mouse liver cell line TAMH has been described as a valuable tool for studying hepatotoxic mechanisms, but until now, it has only been reported to grow as a monolayer in culture. However, culturing hepatocytes as three‐dimensional (3D) spheroids has been shown to result in improved liver‐specific functions (e.g., metabolic capacity) by better mimicking the in vivo environment. This approach may lead to more reliable detection of drug‐induced liver injury (DILI) in the early phase of drug discov… Show more

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