Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension

Ferri, Luca; Alves-Do-Prado, Wilson; Yamada, Sérgio; Gazola, Sebastião; Batista, Márcia Regina; Bazotte, Roberto Barbosa

doi:10.1002/ptr.1944

Cited by 98 publications

(58 citation statements)

References 19 publications

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“…After the interview, blood pressure (BP) and body mass index (BMI) were evaluated. BP (mmHg) was measured as described elsewhere (Ferri et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

Comparative performance of lab tests and blood testing device to monitor glucose, total cholesterol and triacylglycerol in type 2 diabetic patients

Zubioli

Batista

Stefanello

et al. 2011

Braz. J. Pharm. Sci.

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The performance of lab tests (LT) and blood testing devices (BTD) to monitor glycemia vs. glycated hemoglobin A1c (A1c) were compared. In addition, the performance of blood glucose, total cholesterol (TC) and triacylglycerol measured by LT and BDT were compared. All parameters were measured based on the same blood samples from overnight fasted type 2 diabetic patients (T2DP). Linear regression analysis was used for all comparisons. The results showed that A1c correlated better with LT-glucose (r = 0.58) than BTD-glucose (r = 0.42). Moreover, LT vs. BTD showed r values of 0.90, 0.82 and 0.92 for glucose, TC and triacylglycerol, respectively. It was concluded that the performance of LT-glucose was better than BDT-glucose. Moreover, since triacylycerol and TC measured by BTD correlated better with LT compared to BDT-glucose vs. LT-glucose, the inclusion of BTD-TC and BTD-triacylglycerol for detecting and monitoring hyperlipidemia in T2DP should be considered.Uniterms: Laboratory tests. Glycated hemoglobin. Glycemia. Total cholesterol. Triacylglycerol. Type 2 diabetes.Comparou-se a performance de avaliação da glicemia através de dosagens laboratoriais (DL) ou dispositivo para teste de sangue capilar (DTSC) vs. hemoglobina glicada A1c (A1c). Comparou-se ainda a performance de avaliação da glicemia, colesterol total (CT) e triacilglicerol (DL vs. DTSC). Avaliou-se estes parametros a partir das mesmas amostras de sangue coletadas em pacientes diabéticos tipo 2 (PDT2) em jejum noturno, sendo as comparações realizadas através de análise de regressão linear. A A1c correlacionou-se melhor com a glicemia-DL (r = 0,58) em relação a glicemia-DTSC (r = 0,42). Comparou-se DL vs. DTSC obtendo se r = 0,90, 0,82 e 0,92 para glicemia, CT e triacilglicerol, respectivamente. Concluiu-se que houve melhor performance da glicose-DL em relação a glicose-DTSC. Além disso, considerando que o triacilglicerol e TC avaliado através de DTSC correlaciona-se melhor com DL em comparação a DTSC-glicose vs. DL-glicose, a inclusão de DTSC-TC e DTSC-triacilglicerol visando detectar e monitorar hyperlipidemia in PDT2 deve ser considerada.

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“…After the interview, blood pressure (BP) and body mass index (BMI) were evaluated. BP (mmHg) was measured as described elsewhere (Ferri et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

Comparative performance of lab tests and blood testing device to monitor glucose, total cholesterol and triacylglycerol in type 2 diabetic patients

Zubioli

Batista

Stefanello

et al. 2011

Braz. J. Pharm. Sci.

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“…Stevioside and steviol have also been shown to have a direct effect on the beta cells of the pancreas to stimulate the secretion of insulin and improve glucose tolerance that might prove to have a positive impact in the prevention of type 2 diabetes mellitus (Sattigeri, 2012). However, Ferri et al (2006) and others (Chan et al, 2000;Hsieh et al, 2003) reported no significant effect of stevia on glucose homoestasis.…”

Section: Introductionmentioning

confidence: 95%

“…Toxicological reports have also shown that secondary metabolites present in stevia did not have teratogenic, mutagenic (Lemus-Mondaca et al, 2012) or carcinogenic effects. No allergic reactions have been detected following stevia consumption as a sweetener Ferri et al, 2006;Gupta et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Stevia Consumption on Blood Pressure, Stress Hormone Levels and Anthropometrical Parameters in Healthy Persons

Al-Dujaili¹,

Twaij²,

Bataineh³

et al. 2017

American Journal of Pharmacology and Toxicology

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Stevia is a natural sweetener containing steviol glycosides known to be several times sweeter than sucrose. It is thought to have several beneficial properties though some evidence state it may have detrimental effects. The aim of this study was to investigate the potential beneficial or harmful effects of stevia consumption by exploring its effects on blood pressure, stress hormone levels and anthropometrical markers in A crossover placebo controlled study was conducted on 16 volunteers randomly assigned to consume either stevia or a placebo (sugar) for one week. The measurements were attained on three different occasions and each volunteer was allowed a 3-day initiation period before baseline and in between interventions. The systolic BP increased following stevia intake from 114.5±12.7 to 119.9±12.9mmHg (p<0.001) and diastolic BP from 70.8±9.4 to 75.7±9.6mmHg (p<0.01). Systolic BP increased slightly after the sugar placebo to 115.3±13.6 mmHg (not significant). The mean free cortisol excreted in urine has increased from 91.8±49.1 to 125.7±60.5nmole/day (p<0.01) after the stevia and to 109.1±42.6nmole/day after the placebo (p = 0.210). The ratio of urinary free cortisol/cortisone showed a statistically significant increase from 1.73±0.78 to 2.65±1.03 after stevia (p<0.0001). Salivary cortisol levels have also increased (p<0.01 at AM) after stevia. Placebo intake did not produce a significant change in salivary cortisol. The ratio of salivary cortisol/cortisone during the stevia has increased only in the morning (from 1.22±0.65 to 1.75±0.72, p = 0.05) and a modest increase in the daily average of salivary cortisol/cortisone. There was small insignificant reduction in weight and BMI after stevia intervention (p = 0.246 and p = 0.249 respectively). In conclusion, we have shown that short term stevia intake produced a small but significant increase in BP and effect on body weight and BMI were not significant. The rise in BP might be due to the increase in cortisol levels and cortisol/cortisone ratio indicating that stevia may possibly inhibit 11β-HSD2 enzyme by reducing the conversion of cortisol into cortisone. Therefore caution should be taken by the public who want to consume stevia for longer period of time as a weight reducing sweetener.

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“…Stevioside and rebaudioside A also exhibit anti-inflammatory and diuretic properties [19], prevent ulceration of the gastrointestinal tract [18,20] and show antihyperglycemic [21][22][23], anti-hypertensive, …”

Section: Main Characteristics Of Steviol Glycosidesmentioning

confidence: 99%

Main properties of steviol glycosides and their potential in the food industry: a review

González¹,

Tapia²,

Pérez³

et al. 2014

Fruits

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-Introduction. In recent decades, there has been increased interest in developing natural non-caloric sweeteners, providing sensory properties similar to sucrose. One of the most promising alternatives is the steviol glycosides, high-sweetness compounds extracted from the leaves of Stevia rebaudiana Bertoni. Characteristics and properties. In this review article, the characteristics of this plant are described. According to the relevant literature data, this review provides insight into the major steviol glycosides as well as their main characteristics and properties. Toxicity and legislation. We describe the current situation on the toxicity and the legal framework of the above sweeteners. Extraction techniques. This review describes the techniques developed for extraction and purification, including conventional extraction with water/solvent, ion exchange, enzymatic extraction, supercritical fluid and with a focus on membrane filtration, for its proven advantages in the purification of aqueous extract obtained by leaching of the leaves. Applications. This review also presents various evidence relating to the implementation of steviol glycosides in the food industry, with an emphasis on their use in the formulation of fruit juices. Conclusions. Finally, the future prospects of these natural sweeteners are presented. They highlight the need for research in this area, and the great appeal and commercial potential of such compounds, which should be focused on continuous assessment in relation to issues such as the intensity, persistence of sweetness and the absence of other residual flavors, in order to ensure their acceptance, preference and choice by the general public.Stevia rebaudiana / leaves / extraction / glycosides / sweeteners / stevioside / food industry / fruit juices Synthèse sur les principales caractéristiques des glycosides de stéviol et leur intérêt dans l'industrie alimentaire.Résumé -Introduction. Au cours des dernières décennies, il est apparu un intérêt croissant pour le développement des édulcorants naturels, non-caloriques, offrant des propriétés sensorielles similaires à celles du saccharose. Parmi les produits les plus prometteurs apparaissent les glycosides de stéviol, composés très édulcorants extraits des feuilles de Stevia rebaudiana Bertoni. Caractéristiques et propriétés. Dans cette synthèse, nous décrivons les caractéris-tiques de S. rebaudiana. À partir des données de la littérature, cette étude donne un aperçu des principaux glycosides de stéviol et de leurs principales caractéristiques et propriétés ; elle souligne d'autres qualités de ces produits. Toxicité et législation. Nous faisons un point sur la toxicité et le cadre juridique des édulcorants concernés. Techniques d'extraction. Notre synthèse décrit les techniques mises au point pour l'extraction et la purification, y compris l'extraction conventionnelle avec de l'eau ou solvant, l'échange d'ions, l'extraction enzymatique et le fluide supercritique ; elle met l'accent sur la filtration membranaire du fait de ses ava...

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Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension

Cited by 98 publications

References 19 publications

Comparative performance of lab tests and blood testing device to monitor glucose, total cholesterol and triacylglycerol in type 2 diabetic patients

Comparative performance of lab tests and blood testing device to monitor glucose, total cholesterol and triacylglycerol in type 2 diabetic patients

Effect of Stevia Consumption on Blood Pressure, Stress Hormone Levels and Anthropometrical Parameters in Healthy Persons

Main properties of steviol glycosides and their potential in the food industry: a review

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