Investigation of the Antioxidant and Anti-Inflammatory Capacities of Different Extracts from <i>Cistus ladanifer</i> L. Leaves in the Ait Ammart Region (Northern Morocco)

Abstract

Plants are a significant source for identifying new compounds (particularly secondary metabolites) with medicinal value for drug development, pharmaceuticals, and food additives. Many of these healing plants are frequently used in conventional medicine to treat and prevent various diseases. The purpose of the current research is to assess the total phenolic content (TPC) and total flavonoid content (TFC) for phytochemical analysis, DPPH and FRAP (Ferric Reducing Antioxidant Power) assays for antioxidant activity (AOA), and the activity of reducing inflammation exhibited by various extracts, which were determined by measurement of absorbance with a UV spectrophotometer. The outcome demonstrated that the Cistus ladanifer L leaf aqueous extract (EAqCL) has the highest yield (15.581%) and the highest phenolic content (98.28 ± 0.32 mg GAE/g ext ) compared to the other extracts. Whereas, ethanol extract (EECL) exhibited the highest flavonoid content (11.39 ± 1.45 mg QE/g ext ), DPPH-radical scavenging activity (RSA = 94.534 ± 1.24%) at 800 µg/ml and FRAP (1.017 ± 0.12) at 400 μg/mL. The extract also showed better anti-inflammatory activity (95.61 ± 0.92%) at 1000 µg/ml. According to the results obtained, this sticky shrub growing in the Ait Ammart region has great potential for exploiting natural sources of bioactive substances and producing pharmacologically active metabolites.

Phytochemical, antioxidant, and anti-inflammatory properties of Tetraclinis articulata (Vahl) Masters extracts from Al Hoceima province

“…These results explain the importance of solvent polarity in extracting antioxidant compounds from the sample. Indeed, higher-polarity solvents (ethanol and ethyl acetate) extracted more hydrophilic antioxidant compounds, such as flavonoids and polyphenols, due to the presence of hydroxy groups that contribute to antioxidant activity [26,27]. Less-polar solvents, such as hexane, have a stronger affinity for lipophilic compounds, which may include both non-antioxidant and antioxidant compounds [26].…”

In the weeds: A comprehensive review of cannabis; its chemical complexity, biosynthesis, and healing abilities

“…Moreover, this plant possesses inherent antioxidant properties due to phenolic compounds and their ability to scavenge free radicals, such as syringic acid and sinapinic acid, which contributes to the antioxidant and anti-inflammatory activity [175] , [18] , [196] , [2] , [3] , [95] . The antimicrobial efficacy of cannabis’s essential oil was tested against Candida and diverse pathogenic bacterial species, the study reported that it had moderate antimicrobial efficiency and exhibited interesting antioxidant potency [133] .…”

An ethnobotanical investigation of medicinal and aromatic plants used in Al Hoceima National Park

“…Since antiquity, humans have used plants in traditional medicine for several benefits to treat various diseases [1][2][3]. The scientific and technological evolution has approved the importance of aromatic and medicinal plants (AMP), a significant source for developing and synthesizing drugs or pharmacologically active compounds [4].…”