Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives

Stanchev, Stancho; Hadjimitova, Vera; Traykov, T.; Boyanov, Teodor; Manolov, Ilia

doi:10.1016/j.ejmech.2008.07.007

Cited by 54 publications

(23 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They exhibit cytotoxic and spasmolytic activities, and also activity against HIV virus, and analgesic, anti-arthritis, anti-inflammatory, antipyretic, antibacterial, antiviral, and anti-cancer properties. They are also useful key intermediates for many industrial products such as dyes and liquid crystals (Jung and Park 2009;Stanchev et al 2009). …”

Section: Ascomycetes Fungimentioning

confidence: 99%

Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Natural coumarins and derivatives are compounds that occur naturally in several organisms (plant, bacteria, and fungi) consisting of fused benzene and α-pyrone rings. These compounds show high technological potential applications in agrochemical, food, pharmaceuticals, and cosmetics industries. Therefore, the need for bulk production of coumarins and the advancement of the chemical and pharmaceutical industries led to the development of synthetic coumarin. However, biotransformation process, synthetic bioengineering, metabolic engineering, and bioinformatics have proven effective in the production of natural products. Today, these biological systems are recognized as green chemistry innovation and business strategy. This review article aims to report the potential of fungi for synthesis of coumarin. These microorganisms are described as a source of natural products capable of synthesizing many bioactive metabolites. The features, classification, properties, and industrial applications of natural coumarins as well as new molecules obtained by basidiomycetes and ascomycetes fungi are reported in order to explore a topic not yet discussed in the scientific literature.

show abstract

Section: Ascomycetes Fungimentioning

confidence: 99%

Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

“…In addition, a broad array of other therapeutic applications of natural and synthetic coumarins has been reported in the literature, especially concerning their anti-inflammatory / antioxidant properties, [22][23][24][25] their application as neuroprotecting agents, 26 as well as in pharmacotherapy of breast cancer. 27 Furocoumarins are a class of natural and synthetic compounds used as photoreactive, antiviral, antiinflammatory agents as well as kinase inhibitors.…”

Section: This Results Implied An Anti-allergic Action Of Cnidicin In Vmentioning

confidence: 99%

Synthesis and Anti-inflammatory Activity of Novel Furochromenes

et al. 2013

View full text Add to dashboard Cite

Abstract. A series of variously substituted furochromenes, hemiacetals 2, acetals 3, and rearranged compounds 4, were synthesized from variously substituted 4-hydroxycoumarins and evaluated in several in vitro assays, inhibition of mast cell degranulation induced by the activation of Fcε receptor type I or calcium ionophore and leukotriene B 4 (LTB 4 ) inhibition. The most active derivatives, 3p and 4p (8-iso-propyl substitution in coumarin ring) and 3r (5-methyl-8-chloro substitution), showed significant inhibition of mast cell degranulation (Fctriggered) and LTB 4 , and exhibited significant local anti-inflammatory activity in PMA induced ear edema in CD1 mice, with potency equal (compounds 3p and 4p) or better (compound 3r) in comparison with zileuton, a reference drug used. It might be a promising direction for developing novel drugs as potential agents for the treatment of allergies and other inflammatory diseases.(doi: 10.5562/cca2240)

show abstract

“…The structure of benzopyrone group in the coumarin derivatives has many advantages including high fluorescence quantum yield, large Stokes shift, excellent light stability and low toxicity [26][27][28]. Moreover, coumarins play important roles as food constituents, antioxidants, stabilizers, immunomodulatory substances, lasers and anticancer agents [29][30][31][32][33][34]. Coumarin derivatives have also been used as fluorescent probes of pH, for detection of nitric oxide, nitroxide and hydrogen peroxide [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Novel Coumarin Substituted Water Soluble Cyclophosphazenes as “Turn-Off” Type Fluorescence Chemosensors for Detection of Fe3+ ions in Aqueous Media

et al. 2015

View full text Add to dashboard Cite

In the present work, 3-[2-(diethylamino)ethyl]-7-oxy-4-methylcoumarin substituted cyclotriphosphazene (4) and cyclotetraphosphazene (5) derivatives were synthesized by the reactions of hexachlorocyclotriphosphazene (1) or octachlorocyclotetraphosphazene (2) with 3-[2-(diethylamino)ethyl]-7-hydroxy-4-methylcoumarin (3) for the first time. The quaternized cationic (6 and 7) and zwitterionic (8 and 9) derivatives of these compounds (4 and 5) were obtained by the reactions of dimethyl sulfate and 1,3-propanesultone, respectively. All newly synthesized cyclophosphazene compounds (4-9) were fully characterized by elemental analysis and general spectroscopic techniques such as FT-IR, (31)P-NMR, (1)H-NMR and MALDI-TOF mass. All these coumarin substituted cyclophosphazene compounds (4-9) were soluble in most of organic solvents and quaternized ionic and zwitterionic compounds (6-9) also showed excellent solubility in water. The fluorescence behaviors of novel cyclophosphazene compounds were investigated in methanol and water solutions. The chemosensor properties of newly synthesized water soluble quaternized ionic and zwitterionic cyclotriphosphazene and cyclotetraphosphazene derivatives (6-9) were investigated in aqueous media. These cyclophosphazene derivatives showed fluorescence chemosensor behavior with high selectivity for Fe(3+) ions in aqueous solution.

show abstract

Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives

Cited by 54 publications

References 7 publications

Fungi as a source of natural coumarins production

Fungi as a source of natural coumarins production

Synthesis and Anti-inflammatory Activity of Novel Furochromenes

Novel Coumarin Substituted Water Soluble Cyclophosphazenes as “Turn-Off” Type Fluorescence Chemosensors for Detection of Fe3+ ions in Aqueous Media

Contact Info

Product

Resources

About