Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus

Shionoiri, Nozomi; Sato, Tetsuya; Fujimori, Yoshie; Nakayama, Tsuruo; Nemoto, Michiko; Matsunaga, Tadashi; Tanaka, Tsuyoshi

doi:10.1016/j.jbiosc.2011.12.006

Cited by 123 publications

(90 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this current study we have observed that Cu(II) was important in the short term but it is Cu(I) that is the primary effector of copper surface inactivation of norovirus. Shionoiri et al [44] observed Cu(I) was important in inactivation of feline norovirus (FCV), but they investigated copper iodide nanoparticles in solution and Sagripanti et al [45] discovered that superoxide was not involved in the destruction of the double stranded DNA of Herpes Simplex Virus on copper and only partial protection was seen for hydroxyl radicals. We also found that Cu(I) release on contact surfaces did not result in the generation of hydroxyl radicals or superoxide indicating Fenton chemistry is not important.…”

Section: Discussionmentioning

confidence: 99%

Inactivation of Norovirus on Dry Copper Alloy Surfaces

2013

View full text Add to dashboard Cite

Noroviruses (family Caliciviridae) are the primary cause of viral gastroenteritis worldwide. The virus is highly infectious and touching contaminated surfaces can contribute to infection spread. Although the virus was identified over 40 years ago the lack of methods to assess infectivity has hampered the study of the human pathogen. Recently the murine virus, MNV-1, has successfully been used as a close surrogate. Copper alloys have previously been shown to be effective antimicrobial surfaces against a range of bacteria and fungi. We now report rapid inactivation of murine norovirus on alloys, containing over 60% copper, at room temperature but no reduction of infectivity on stainless steel dry surfaces in simulated wet fomite and dry touch contamination. The rate of inactivation was initially very rapid and proportional to copper content of alloy tested. Viral inactivation was not as rapid on brass as previously observed for bacteria but copper-nickel alloy was very effective. The use of chelators and quenchers of reactive oxygen species (ROS) determined that Cu(II) and especially Cu(I) ions are still the primary effectors of toxicity but quenching superoxide and hydroxyl radicals did not confer protection. This suggests Fenton generation of ROS is not important for the inactivation mechanism. One of the targets of copper toxicity was the viral genome and a reduced copy number of the gene for a viral encoded protein, VPg (viral-protein-genome-linked), which is essential for infectivity, was observed following contact with copper and brass dry surfaces. The use of antimicrobial surfaces containing copper in high risk closed environments such as cruise ships and care facilities could help to reduce the spread of this highly infectious and costly pathogen.

show abstract

Section: Discussionmentioning

confidence: 99%

Inactivation of Norovirus on Dry Copper Alloy Surfaces

2013

View full text Add to dashboard Cite

show abstract

“…Such interactions do not always lead to a complete loss of viral infectivity, but sometimes a notable effect was achieved, e.g. a decrease in the HA titre of H1N1 influenza A virus in response to AgNPs from 1:1024 to 1:2, a 7-log reduction of feline calicivirus titre under the influence of copper iodide NPs, or complete inhibition of Tacaribe virus replication in the presence of AgNPs (Speshock et al 2010, Xiang et al 2011, Shionoiri et al 2012. The decline of the ECBO virus titre observed in this experiment from 0.5-0.875 log seems to imply some interactions of the analyzed nanocolloids with the test virus, but insufficent to claim they are virucidal agents useful in the veterinary area.…”

Section: Resultsmentioning

confidence: 99%

Commercial metal-based nanocolloids – lack of virucidal activity against ECBO virus

Małaczewska¹,

Siwicki²

2014

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Metallic nanoparticles, mainly silver ones, have been widely used as antibacterial agents, and some studies shown they also exert direct antiviral activity against both enveloped and non-enveloped viruses. The objective of this study has been to evaluate the virucidal activity of commercial silver, gold, copper and platinum nanocolloids, recommended by the manufacturer as antimicrobials, against the ECBO virus, according to Polish Standard PN-EN 14675:2006. The highest experimentally observed decrease in the viral load was 0.875 log, which -when contrasted with the reduction in virus titre of at least 4 log expected from disinfectants -indicates that none of the analyzed nanocolloids had a disinfectant power towards the ECBO virus under the conditions defined by the standard.

show abstract

“…The literature that has included evaluations of inactivation efficacy of oxidizing agents for caliciviruses is extensive [8,9,18,31,42,69,70,72,73,75,77,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108], due in part to the relative importance of the human noroviruses as human enteric pathogens and the need to identify efficacious agents for disinfection of food and food preparation surfaces. The calicivirus inactivation efficacy information for these agents determined in coupon studies (virus dried onto surfaces) and in solution studies is summarized in Table 7.…”

Section: Resultsmentioning

confidence: 99%

“…The mechanism underlying the inactivation of caliciviruses by the stabilized silver disinfectant [104] is likely similar to that of metallic copper. In the latter case, it appears that it is the solvated free cupper ions that mediate the inactivation of caliciviruses [105]. As with the other active oxygen-based disinfectants, the solvated copper ions generate reactive oxygen species and it is the latter that cause the observed oxidation of viral capsid proteins (105).…”

Section: Resultsmentioning

confidence: 99%

Inactivation of Caliciviruses

Nims¹,

Plavsic²

2013

Pharmaceuticals

View full text Add to dashboard Cite

The Caliciviridae family of viruses contains clinically important human and animal pathogens, as well as vesivirus 2117, a known contaminant of biopharmaceutical manufacturing processes employing Chinese hamster cells. An extensive literature exists for inactivation of various animal caliciviruses, especially feline calicivirus and murine norovirus. The caliciviruses are susceptible to wet heat inactivation at temperatures in excess of 60 °C with contact times of 30 min or greater, to UV-C inactivation at fluence ≥30 mJ/cm2, to high pressure processing >200 MPa for >5 min at 4 °C, and to certain photodynamic inactivation approaches. The enteric caliciviruses (e.g.; noroviruses) display resistance to inactivation by low pH, while the non-enteric species (e.g.; feline calicivirus) are much more susceptible. The caliciviruses are inactivated by a variety of chemicals, including alcohols, oxidizing agents, aldehydes, and β-propiolactone. As with inactivation of viruses in general, inactivation of caliciviruses by the various approaches may be matrix-, temperature-, and/or contact time-dependent. The susceptibilities of the caliciviruses to the various physical and chemical inactivation approaches are generally similar to those displayed by other small, non-enveloped viruses, with the exception that the parvoviruses and circoviruses may require higher temperatures for inactivation, while these families appear to be more susceptible to UV-C inactivation than are the caliciviruses.

show abstract

Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus

Cited by 123 publications

References 31 publications

Inactivation of Norovirus on Dry Copper Alloy Surfaces

Inactivation of Norovirus on Dry Copper Alloy Surfaces

Commercial metal-based nanocolloids – lack of virucidal activity against ECBO virus

Inactivation of Caliciviruses

Contact Info

Product

Resources

About