Investigation of the application of a Taylor-Couette bioreactor in the post-processing of bioprinted human dermal tissue

Teoh, Jia Heng; Thamizhchelvan, Anbu Mozhi; Davoodi, Pooya; Ramasamy, Srinivas; Vijayavenkataraman, Sanjairaj; Yang, Qiaoyun; DiColandrea, Teresa; Zhao, Helen; Fuh, Jerry Ying Hsi; Liou, Yih Cherng; Wang, Chi Hwa

doi:10.1016/j.bej.2019.107317

Cited by 16 publications

(6 citation statements)

References 31 publications

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“…), or other specific skin types depending on the intended use of the cosmetic as these models incorporate iPSC-derived cells. Collagen-based skin construct reinforced with biocompatible materials such as polycaprolactone (PCL) mesh prevented the contraction of collagen during tissue maturation and enable manufacturing of biomimetic human skin models[ 144 , 145 ]. Other biomaterials such as polylactic acid, Pluronic, alginate, chitosan, hyaluronic acid, fibrin, and gelatin, or a combination of PEGDA and GelMA were used as the scaffold material for printing skin models[ 145 - 147 ].…”

Section: Application Of Bioprinted Ipscs In Healthcarementioning

confidence: 99%

Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare

Soman¹,

Vijayavenkataraman²

2024

IJB

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Induced pluripotent stem cell (iPSC) technology and advancements in three-dimensional (3D) bioprinting technology enable scientists to reprogram somatic cells to iPSCs and 3D print iPSC-derived organ constructs with native tissue architecture and function. iPSCs and iPSC-derived cells suspended in hydrogels (bioinks) allow to print tissues and organs for downstream medical applications. The bioprinted human tissues and organs are extremely valuable in regenerative medicine as bioprinting of autologous iPSC-derived organs eliminates the risk of immune rejection with organ transplants. Disease modeling and drug screening in bioprinted human tissues will give more precise information on disease mechanisms, drug efficacy, and drug toxicity than experimenting on animal models. Bioprinted iPSC-derived cancer tissues will aid in the study of early cancer development and precision oncology to discover patient-specific drugs. In this review, we present a brief summary of the combined use of two powerful technologies, iPSC technology, and 3D bioprinting in health-care applications.

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Section: Application Of Bioprinted Ipscs In Healthcarementioning

confidence: 99%

Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare

Soman¹,

Vijayavenkataraman²

2024

IJB

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“…To guarantee satisfactory outcomes in meniscal devices fabrication, great attention must be paid to the pre-processing (selection of materials, cells and customized construct design) and processing (choice of printing technique) phases; however, post-processing is a peculiar step too, aiming to scaffold structural optimization and, when required, maturation of the seeded/bioprinted support to allow for further cell growth, proliferation, and differentiation. 219 To this purpose, bioreactors may have a key role. These systems, together with provision of adequate and constant environmental parameters (pH, temperature, CO 2 concentration) favoring cell growth, also impart a convective flow to cell culture medium (mimicking the in vivo conditions) and assert mechanical forces on the cells improving tissue growth.…”

Section: D Printing/bioprinting Of Meniscus: Issues In Scaffolds Design and Developmentmentioning

confidence: 99%

Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

et al. 2022

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Meniscal tears are a frequent orthopedic injury commonly managed by conservative strategies to avoid osteoarthritis development descending from altered biomechanics. Among cutting-edge approaches in tissue engineering, 3D printing technologies are extremely promising guaranteeing for complex biomimetic architectures mimicking native tissues. Considering the anisotropic characteristics of the menisci, and the ability of printing over structural control, it descends the intriguing potential of such vanguard techniques to meet individual joints’ requirements within personalized medicine. This literature review provides a state-of-the-art on 3D printing for meniscus reconstruction. Experiences in printing materials/technologies, scaffold types, augmentation strategies, cellular conditioning have been compared/discussed; outcomes of pre-clinical studies allowed for further considerations. To date, translation to clinic of 3D printed meniscal devices is still a challenge: meniscus reconstruction is once again clear expression of how the integration of different expertise (e.g., anatomy, engineering, biomaterials science, cell biology, and medicine) is required to successfully address native tissues complexities.

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“…Human primary foreskin-derived dermal fibroblasts [137] Chitosan-based bioink Chitosan is derived from chitin, a polysaccharide from the exoskeleton of shrimp and other sea crustaceans. It has a linear structure, which can be quickly formed into a gel matrix using NaOH [133].…”

Section: Bioinks For 3d Printing Technologymentioning

confidence: 99%

The 3D Bioprinted Scaffolds for Wound Healing

et al. 2022

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Skin tissue engineering and regeneration aim at repairing defective skin injuries and progress in wound healing. Until now, even though several developments are made in this field, it is still challenging to face the complexity of the tissue with current methods of fabrication. In this review, short, state-of-the-art on developments made in skin tissue engineering using 3D bioprinting as a new tool are described. The current bioprinting methods and a summary of bioink formulations, parameters, and properties are discussed. Finally, a representative number of examples and advances made in the field together with limitations and future needs are provided.

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Investigation of the application of a Taylor-Couette bioreactor in the post-processing of bioprinted human dermal tissue

Cited by 16 publications

References 31 publications

Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare

Applications of 3D Bioprinted-Induced Pluripotent Stem Cells in Healthcare

Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

The 3D Bioprinted Scaffolds for Wound Healing

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