Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

Taş, Ayça; Atabey, Mustafa; Caglayan, Gulcin; Bostancı, Meriç Emre; Bölükbaşı, Serap Şahin; Topçu, Ömer; Siliğ, Yavuz

doi:10.3892/br.2017.978

Cited by 6 publications

(9 citation statements)

References 28 publications

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“…Sp1 binds with higher affinity to the G allele than to the T allele, which accounts for increased transcription of the MDM2 gene and higher expression levels of MDM2 protein, and thereby inhibits the function of p53 pathway in the prevention of tumor formation. [24] Our results evaluated MDM2 rs2279744 polymorphism may be a risk factor for the development of RB. Prediction intervals were calculated for MDM2 rs2279744.…”

Section: Discussionmentioning

confidence: 99%

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Cao

Wang

Song³

et al. 2018

Medicine

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Retinoblastoma (Rb) is the most common intra-ocular malignancy in children. The association of rs2279744, and rs937283 in MDM2 gene, and p21 rs1801270 polymorphism and RB development have been demonstrated. To provide a comprehensive assessment of and to clarify associations between the 3 SNPs (MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270) and the risk of RB, we performed a meta-analysis of all the eligible case-control studies. We searched English databases include PubMed, Embase, Google Scholar, and Cochrane Library, using an upper date limit of January 1, 2018. The association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and the risk of RB were estimated by calculating a pooled OR and 95% CI under a homozygote comparison, heterozygote comparison, dominant model, and recessive model. The statistical power analysis was performed using G∗Power. Our meta-analysis showed a significant association between RB susceptibility and MDM2 rs2279744 recessive model (OR = 1.427, 95%CI: 1.107-1.840, P = .006, I2 = 0%). Moreover, a significant link was observed between RB risk and MDM2 rs937283 homozygote comparison (OR = 0.471, 95%CI: 0.259-0.858, P = .014, I2 = 0%) and recessive model (OR = 0.587, 95%CI: 0.410-0.840, P = .004, I2 = 0%). However, no significant relationship between the p21 rs1801270 polymorphism and RB susceptibility was detected in any of the 4 models (P > .05). In conclusion, we found that significant association between the MDM2 rs2279744 polymorphism and increased RB risk, while MDM2 rs937283 polymorphism was associated with significantly decreased RB risk. However, as to the P21 rs1801270 polymorphism, a statistically significant association was not identified for RB.

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Section: Discussionmentioning

confidence: 99%

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Cao

Wang

Song³

et al. 2018

Medicine

View full text Add to dashboard Cite

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“…The negative control was included in each experiment to ensure the accuracy of the amplification. The primer sequences were described previously [ 4 , 5 , 41 , 42 , 43 ]. The thermal conditions and primer sequences are shown in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Associations of MDM2 and MDM4 Polymorphisms with Early-Stage Breast Cancer

Bartnykaitė

Savukaitytė

Ugenskienė

et al. 2021

JCM

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Breast cancer is one of the most common cancers worldwide. Single nucleotide polymorphisms (SNPs) in MDM2 and MDM4 have been associated with various cancers. However, the influence on clinical characteristics of breast cancer has not been sufficiently investigated yet. Thus, this study aimed to investigate the relationship between SNPs in MDM2 (rs2279744, rs937283, rs937282) and MDM4 (rs1380576, rs4245739) and I–II stage breast cancer. For analysis, the genomic DNA was extracted from 100 unrelated women peripheral blood. Polymorphisms were analyzed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The study showed that MDM2 rs937283 and rs937282 were significantly associated with estrogen receptor status and human epidermal growth factor receptor 2 (HER2) status. SNPs rs1380576 and rs4245739, located in MDM4, were significantly associated with status of estrogen and progesterone receptors. Our findings suggest that rs937283 AG, rs937282 CG, rs1380576 CC, and rs4245739 AA genotypes were linked to hormonal receptor positive breast cancer and may be useful genetic markers for disease assessment.

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“…A total of 14 manuscripts were assessed for full-review, of which three were excluded: One manuscript was not available, one had a duplicated population of another published study and one was not a case-controlled study. After the revision process, a total of 11 articles were used for data analysis (21,23,(26)(27)(28)(29)(30)(31)(32)(33)(34). Amongst the included studies, 10 studies were performed in Asian populations and one in a Brazilian population.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Association of Murine Double Minute 2 polymorphisms with gastric cancer: A systematic review with meta‑analysis

et al. 2021

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Gastric cancer (GC) is the 5th most common type of cancer, with the 3rd highest mortality rate worldwide in both sexes. Murine double minute 2 (MDM2) protein is the major negative regulator of p53, and genetic polymorphisms in this gene have shown to be associated with several types of cancer. In the present study, a literature search was performed using PubMed and Scopus with the following key word combinations 'gastric cancer AND polymorphism AND MDM2'. Studies were carefully revised according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify eligible studies that matched the inclusion criteria. Statistical analysis was performed to assess the association between the different genetic polymorphisms and GC risk, by calculating the odds ratios (OR) and the confidence intervals (CI), with a 5% level of significance. A total of 11 manuscripts studied MDM2 polymorphisms in GC: rs937283 (n=1), rs3730485 (n=1) and rs2279744 (n=9). Both the rs937283 and rs3730485 reports showed an association with GC; however, there was only one study on each of these polymorphisms in the literature. A meta-analysis was performed for the rs2279744 polymorphism, of which studies showed a positive association between the G allele and risk of GC, either in the dominant model (OR=1.46; 95% CI 1.21-1.75; P<0.001) or recessive model (OR 1.65; 95% CI 1.45-1.87; P<0.001). In conclusion, genetic polymorphisms in MDM2 seemed to be associated with an increased risk of GC development, nevertheless, the number of studies were relatively low and the studied populations were primarily Chinese. The present meta-analysis emphasizes the need for additional studies in other populations to corroborate the association of these polymorphisms with GC.

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Investigation of the association between the MDM2 T309G polymorphism and gastric cancer

Cited by 6 publications

References 28 publications

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Associations of MDM2 and MDM4 Polymorphisms with Early-Stage Breast Cancer

Association of Murine Double Minute 2 polymorphisms with gastric cancer: A systematic review with meta‑analysis

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