Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate

Liu, Wei; Hu, Meiling; Liu, Wenshuang; Xue, Chengbin; Xu, Huibi; Yang, Xiangliang

doi:10.1016/j.ijpharm.2008.08.013

Cited by 133 publications

(64 citation statements)

References 26 publications

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“…This indicated that CP934, EL-40, and 1,2-propylene glycol are safe for topical use. 15,28 The SC is a formidable barrier that inhibits substances from penetrating into the deep skin layers where immune reactions can be triggered, especially the release of histamine by mast cells during inflammation or allergy. 29,30 Barbier and Benezra 31 reported that guinea pigs are sensitive to CIT, exhibiting delayed skin hypersensitivity after 24 h exposure at 0.5% (v/v, 0.5 mL).…”

Section: Skin Irritation Testmentioning

confidence: 99%

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Zheng¹,

Ouyang²,

Wei³

et al. 2016

IJN

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Section: Skin Irritation Testmentioning

confidence: 99%

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Zheng¹,

Ouyang²,

Wei³

et al. 2016

IJN

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“…The better thixotropy of our developed SLN formulation is probably due to interference of the lipid with hydrogen-bond reformation during gel structure recovery phase. This behavior is believed to slow down the rebuilding of gel three-dimensional network (Liu et al, 2008).…”

Section: Rheology Of the Kp-sln Gelmentioning

confidence: 99%

Topical ketoprofen nanogel: artificial neural network optimization, clustered bootstrap validation, and in vivo activity evaluation based on longitudinal dose response modeling

et al. 2016

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Objectives: This work aimed at investigating the potential of solid lipid nanoparticles (SLN) as carriers for topical delivery of Ketoprofen (KP); evaluating a novel technique incorporating Artificial Neural Network (ANN) and clustered bootstrap for optimization of KP-loaded SLN (KP-SLN); and demonstrating a longitudinal dose response (LDR) modeling-based approach to compare the activity of topical non-steroidal anti-inflammatory drug formulations. Methods: KP-SLN was fabricated by a modified emulsion/solvent evaporation method. BoxBehnken design was implemented to study the influence of glycerylpalmitostearate-to-KP ratio, Tween 80, and lecithin concentrations on particle size, entrapment efficiency, and amount of drug permeated through rat skin in 24 hours. Following clustered bootstrap ANN optimization, the optimized KP-SLN was incorporated into an aqueous gel and evaluated for rheology, in vitro release, permeability, skin irritation and in vivo activity using carrageenan-induced rat paw edema model and LDR mathematical model to analyze the time course of anti-inflammatory effect at various application durations. Results: Lipid-to-drug ratio of 7.85 ], Tween 80 of 1.27% [bootstrap 95%CI: 0.601-2.40%], and Lecithin of 0.263% [bootstrap 95%CI: 0.263-0.328%] were predicted to produce optimal characteristics. Compared with profenid Õ gel, the optimized KP-SLN gel exhibited slower release, faster permeability, better texture properties, greater efficacy, and similar potency. Conclusions: SLNs are safe and effective permeation enhancers. ANN coupled with clustered bootstrap is a useful method for finding optimal solutions and estimating uncertainty associated with them. LDR models allow mechanistic understanding of comparative in vivo performances of different topical formulations, and help design efficient dermatological bioequivalence assessment methods.

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“…Some drugs such as triptolide, triamcinolone acetonide acetate, cyclosporin A have been used to be entrapped in SLN [157][158][159]. SLN can be admixed to an already commercially available and established topical formulation, e.g.…”

Section: Applications Of Nanocarrier Systems In Topical/transdermal Dmentioning

confidence: 99%

“…They show promising results in the delivery of drugs such as tamsulosin [192], indomethacin [193], ketoprofen and diflunisal [194 ] and 5-fluorouracil [195]. The main problems with this kind of transdermal carrier are poor biodegradation and inherent cytotoxicity [158]. In order to get down the toxicity dendrimers have been linked to peptides (dendrimers-peptides) from amino acids linked via peptide-amide bonds to the branches of dendrimers in the core or on the surface [159,160].…”

Section: Applications Of Nanocarrier Systems In Topical/transdermal Dmentioning

confidence: 99%

Nanocarrier Systems for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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is an open discussion, in one hand, the nanotechnologist continue making new and more sophisticated nanocarriers and in the other hand, toxicologist continue evaluating possible damaging effects.Whatever it happens, nanotechnology is the new era and nanomedicine cannot be taking off. New nanocarriers will be created and the entire scientist working in nanomedicine bet for it to be the cure of diseases that in this moment are difficult to deal with [3] The application of preparations to the skin for medical purposes is as old as the history of medicine itself, with references to the use of ointments and salves found in the records of Babylonian and Egyptian medicine. The historical development of permeation research is well described by Hadgraft & Lane [4]. Over time, the skin has become an important route for drug delivery in which topical, regional or systemic effects are desired. Nevertheless, skin constitutes an excellent barrier and presents difficulties for the transdermal delivery of therapeutic agents, since few drugs possess the characteristics required to permeate across the stratum corneum in sufficient quantities to reach a therapeutic concentration in the blood. In order to enhance drug transdermal absorption different methodologies have been investigated developed and patented [5,6]. Improvement in physical permeationenhancement technologies has led to renewed interest in transdermal drug delivery. Some of these novel advanced transdermal permeation enhancement technologies include: iontophoresis, electroporation, ultrasound, microneedles to open up the skin and more recently the use of transdermal nanocarriers [3,[7][8][9][10].A number of excellent reviews that have been published contain detailed discussions concerning many aspects of transdermal nanocarriers [11][12][13][14][15][16][17]. The present chapter shows an updated overview of the use of submicron particles and other nanostructures in the pharmaceutical field, specifically in the area of topical and transdermal drugs. This focus is justified due to the magnitude of the experimental data available with the use of these nanocarriers. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been emerged in the last decades for designing best formulations for application through the skin [18][19][20][21]. The skinThe skin is the largest organ of the body [22][23][24], accounting for more than 10% of body mass, and the one that enables the body to interact more intimately with its environment. Essentially, the skin consists of four layers: The SC, that is the outer layer of the skin (nonviable epidermis), and forms the rate-controlling barrier for diffusion for almost all compounds. It is composed of dead flattened, keratin-rich cells, the corneocytes. These dense cells are surrounded by a complex mixture of intercellular lipids, namely, ceramides, free fatty acids, cholesterol, and cholesterol sulphate. Their most important feature is that they are structured as ordered bilayer arrays [25]...

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Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate

Cited by 133 publications

References 26 publications

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Topical ketoprofen nanogel: artificial neural network optimization, clustered bootstrap validation, and in vivo activity evaluation based on longitudinal dose response modeling

Nanocarrier Systems for Transdermal Drug Delivery

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Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate

Cited by 133 publications

References 26 publications

Effects of Carbopol<sup>&reg;</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>&reg;</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Topical ketoprofen nanogel: artificial neural network optimization, clustered bootstrap validation, and in vivo activity evaluation based on longitudinal dose response modeling

Nanocarrier Systems for Transdermal Drug Delivery

Contact Info

Product

Resources

About

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study