Investigation of the cellular tropism of bovine immunodeficiency-like virus

Heaton, Paul R.; Johnstone, Philippa; Brownlie, Joe

doi:10.1016/s0034-5288(98)90024-8

Cited by 14 publications

(4 citation statements)

References 29 publications

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“…Localization of BIV provirus in brain and lymphoid tissues was consistent with the observations of others [14][15][16]39]. Torpidity, stupor, dullness and reduced vitality were observed and clinically attributed to the systemic effect of the multiple subcutaneous abscesses and laminitis, but were possibly the result of lentiviral-induced CNS lesions [10,40].…”

Section: Discussionsupporting

confidence: 89%

Natural bovine lentiviral type 1 infection in Holstein dairy cattle. I. Clinical, serological, and pathological observations

Snider

Hoyt

Coats

et al. 2003

Comparative Immunology, Microbiology and Infectious Diseases

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Clinical, serological, and pathological abnormalities observed in Holstein cows naturally infected with bovine lentivirus 1 bovine immunodeficiency virus (BIV) and other infections were progressive and most commonly associated with weight loss, lymphoid system deficiency, and behavioral changes. Clinical evidence of meningoencephalitis was dullness, stupor, and occasional head or nose pressing postures. The polymerase chain reactions associated the BIV provirus with the lesions in the central nervous system and lymphoid tissues. Multiple concurrent infections developed in retrovirally infected cows undergoing normal stresses associated with parturition and lactation. A major functional correlate of the lymphoreticular alterations was the development of multiple secondary infections which failed to resolve after appropriate antibacterial therapy. The chronic disease syndrome in dairy cows associated with BIV may be useful as a model system for investigation of the pathogenesis of the nervous system lesions and lymphoid organ changes that occur in humans with lentiviral infection.

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Section: Discussionsupporting

confidence: 89%

Natural bovine lentiviral type 1 infection in Holstein dairy cattle. I. Clinical, serological, and pathological observations

Snider

Hoyt

Coats

et al. 2003

Comparative Immunology, Microbiology and Infectious Diseases

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“…The significance of this coinfection is not clear, and it was suggested that BLV might serve as cofactor for BIV replication (Snider et al 1997). This assumption was additionally supported by the fact that BIV and BLV share common host cell tropisms, specifically for B-lymphocytes and monocytes (Heaton et al 1998). …”

Section: Introductionmentioning

confidence: 93%

Serological survey for bovine immunodeficiency virus in dairy cattle from Poland

Rola–Łuszczak¹,

Kozaczynska²,

Kuźmak³

2011

Polish Journal of Veterinary Sciences

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A seroprevalence study of bovine immunodeficiency virus (BIV) was undertaken on 1,541 serum samples from Holstein cattle from 23 herds, located in different geographical regions of Poland. The analysis was performed using ELISA, with recombinant Gag protein of BIV as antigen. The average BIV prevalence was 4.9% in individual cattle, while the percentage of herds harboring at least one seropositive animal, was 82.6%. To demonstrate the correlation of BIV and bovine leukemia virus infection, all sera were analysed for BLV antibodies and there was only a slight association between both infections. Overall, these results show that BIV infection is present in dairy cattle in Poland at a prevalence rate found in other European countries.

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“…BIV infects, in vivo , mainly monocytes, macrophages, and lymphocytes [ 72 ]. Neuropathic BIV strains probably infect macrophages and microglia in the central nervous system (CNS), as other lentiviruses [ 73 ]. In vitro , BIV is able to replicate in several types of cells, as fibroblast-like cells, establishing persistent infections in different primary cultures of bovine cells, from lung, brain, or spleen.…”

Section: Innate Immunitymentioning

confidence: 99%

Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses

Pablo-Maiso

Doménech

Echeverría

et al. 2018

Viruses

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Lentiviruses are infectious agents of a number of animal species, including sheep, goats, horses, monkeys, cows, and cats, in addition to humans. As in the human case, the host immune response fails to control the establishment of chronic persistent infection that finally leads to a specific disease development. Despite intensive research on the development of lentivirus vaccines, it is still not clear which immune responses can protect against infection. Viral mutations resulting in escape from T-cell or antibody-mediated responses are the basis of the immune failure to control the infection. The innate immune response provides the first line of defense against viral infections in an antigen-independent manner. Antiviral innate responses are conducted by dendritic cells, macrophages, and natural killer cells, often targeted by lentiviruses, and intrinsic antiviral mechanisms exerted by all cells. Intrinsic responses depend on the recognition of the viral pathogen-associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs), and the signaling cascades leading to an antiviral state by inducing the expression of antiviral proteins, including restriction factors. This review describes the latest advances on innate immunity related to the infection by animal lentiviruses, centered on small ruminant lentiviruses (SRLV), equine infectious anemia virus (EIAV), and feline (FIV) and bovine immunodeficiency viruses (BIV), specifically focusing on the antiviral role of the major restriction factors described thus far.

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Investigation of the cellular tropism of bovine immunodeficiency-like virus

Cited by 14 publications

References 29 publications

Natural bovine lentiviral type 1 infection in Holstein dairy cattle. I. Clinical, serological, and pathological observations

Natural bovine lentiviral type 1 infection in Holstein dairy cattle. I. Clinical, serological, and pathological observations

Serological survey for bovine immunodeficiency virus in dairy cattle from Poland

Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses

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