2016
DOI: 10.1507/endocrj.ej15-0587
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Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure

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Cited by 8 publications
(9 citation statements)
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“…Based on our data, secondary adrenocortical insufficiency can be confirmed or ruled out in male patients with an Fmax of <12.8 to >19.8 μg/dL using the GHRP2T, respectively. The results of two previous similar studies were controversial with regard to the correlation between the two tests [ 9 , 10 ]. However, the female subjects formed ~50% (7 of 15) or >50% (29 of 47) of the subjects in those two studies, and they did not include sufficient numbers of patients to allow for a proper analysis of the interaction factors.…”
Section: Discussionmentioning
confidence: 99%
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“…Based on our data, secondary adrenocortical insufficiency can be confirmed or ruled out in male patients with an Fmax of <12.8 to >19.8 μg/dL using the GHRP2T, respectively. The results of two previous similar studies were controversial with regard to the correlation between the two tests [ 9 , 10 ]. However, the female subjects formed ~50% (7 of 15) or >50% (29 of 47) of the subjects in those two studies, and they did not include sufficient numbers of patients to allow for a proper analysis of the interaction factors.…”
Section: Discussionmentioning
confidence: 99%
“…Kano et al [ 9 ] compared the GHRP2T and ITT in 15 patients suspected of hypopituitarism and concluded that the GHRP2T was a suitable alternative to the ITT for the assessment of HPA axis function. In contrast, the study by Arimura et al [ 10 ] in 47 patients suspected of having a hypothalamic–pituitary disorder concluded that the GHRP2T did not have the same predictive value as the ITT. These results suggest that more studies of larger population samples are needed to confirm the usefulness of the GHRP2T as a substitute for the ITT and to explain the differences between the two tests.…”
mentioning
confidence: 87%
“…The administration of exogenous GRF, LHRH, TRH, and CRH produced incomplete secretion of pituitary GH, gonadotropins, and TSH and apparently adequate release of prolactin and ACTH, while the cortisol release was insufficient (Table 3B). The patient showed poor GH release, but adequate ACTH release with insufficient cortisol release in response to the administration of GHRP-2 (Table 3C), which is a secretagogue of both pituitary GH and ACTH (25). Brain MRI showed a thin pituitary stalk and deformed pituitary gland (Figure E-G).…”
Section: Discussionmentioning
confidence: 99%
“…A growth hormone-releasing peptide-2 loading test [13] performed in March 2019 showed normal growth hormone release; ACTH release was apparently normal, whereas no adequate cortisol response was observed (Table 2D). The patient's plasma renin activity (0.5 ng/mL/hour) and serum aldosterone level (9.2 ng/dL) were normal, but his serum dehydroepiandrosterone sulfate level (393 ng/dL) [14] was decreased compared with 1 year earlier (1024 ng/dL; Table 1).…”
Section: Case Reportmentioning
confidence: 99%