Ensuring the safety and stability of buildings during earthquakes is of utmost importance. This can be achieved by assessing the seismic performance of reinforced concrete structures with consideration of design details. This study focused on the seismic behavior of reinforced concrete buildings by comparing the effects of two different types of stirrups, namely those with a 135° angled end-hook shape and straight hooks, with variation of concrete strength. Pushover analysis of a sample building was performed to determine the effect of hook shape on stirrup reinforcement with a constant volumetric ratio for various concrete strength classes. The results of the analysis indicated significant differences in concrete strength and seismic behavior between the two stirrup configurations. The hooked stirrups demonstrated superior energy dissipation capability and ductility, which led to better seismic performance compared to unhooked stirrups across varying levels of concrete strength. To extend the investigation, the study compared the Mander et al., Kent–Scott–Park, and Kappos–Konstantinidis concrete models with different concrete classes (C50-C25-C20-C16-C10). The findings emphasized the importance of stirrup configuration in the design of earthquake-resistant structures. The study concluded that RC structural performance with the 135-degree hooked concrete members exhibited much better behavior of the 90-degree members for the various concrete strength. In this way, it has been revealed the arrangement and detailing of reinforcement in the construction beams and columns improves the governing effect on seismic structural performance.