Investigation of the copolymerization of methacrylic acid with methyl acrylate and butyl methacrylate in water-dioxan solvent systems

Bezuglyi, V. D.; Voskresenskaya, I.B.; Alekseyeva, T.A.; Gerner, M.M.

doi:10.1016/0032-3950(75)90222-1

Cited by 1 publication

(1 citation statement)

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“…[23] Qui et al have fabricated butyl methacrylate-methacrylic acid copolymer shell microcapsules containing n-alkane for the storage of thermal energy. [24] Copolymerization of methacrylic acid with butylmethacrylate in water-dioxan mixture was investigated by Bezuglyi et al [25].…”

Section: Copolymer Characterizationmentioning

confidence: 99%

Methacrylic acid-co-butylmethacrylate copolymers: design, characterization and evaluation as encapsulating material for colon targeted formulations

Arya

Pathak

Majumdar

et al. 2015

Designed Monomers and Polymers

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Hydrophilic monomer methacrylic acid was copolymerized with hydrophobic monomer butylmethacrylate in different molar ratio, using AIBNfree radical initiator. Successful polymerization was confirmed by FTIR and 1 H NMR, while DSC and XRD revealed the amorphous nature of the polymers. Copolymers were highly hemocompatible. The polymers showed pH-dependent swelling and erosion which increased with increase in pH. As the amount of methacrylic acid increased, the swelling and erosion also increased. Polymers were used for the microencapsulation of a model anti-inflammatory drug, aceclofenac by an oil-in-oil solvent evaporation method. Microparticles were characterized using FTIR, XRD, DSC, and SEM analysis. The negatively charged particles were almost spherical in shape. The drug release was best explained by zero-order kinetics with anomalous release mechanism. Less than 1% of drug was released at pH 1.2 while the bulk of the drug load was released at pH 6.8 or above, confirming the colon-targeting nature. The microparticles showed significant lowering in myeloperoxidase activity in trinitrobenzene sulfonic acidinduced colitis rat model. There was a significant lowering in the severity of disease symptoms and colonto-body weight ratio. The histopathological studies also confirmed successful treatment with microparticle formulation.

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Section: Copolymer Characterizationmentioning

confidence: 99%