Investigation of the correlation of serum <scp>IL</scp>‐31 with severity of dermatitis in an experimental model of canine atopic dermatitis using beagle dogs

Marsella, Rosanna; Ahrens, Kim; Sanford, Rachel

doi:10.1111/vde.12500

Cited by 17 publications

(19 citation statements)

References 13 publications

(36 reference statements)

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“…A previous study reported that the production of IL‐17A in the peripheral blood mononuclear cells of dogs was associated with adverse food reaction (AFR) . It was suggested that the possible association of IL‐17 with concurrent bacterial infection was because IL‐17 was not correlated with clinical improvement but rather with the bacterial count . However, in our study, none of the dogs with AD was suffering from concurrent microbial infection.…”

Section: Discussioncontrasting

confidence: 64%

“…Marked elevation in IL‐31 in pruritic versus nonpruritic human skin conditions and correlation of serum IL‐31 concentrations with the severity of disease in adult humans and children with AD has been documented . Similarly, a positive correlation between the severity of canine AD and circulating IL‐31 concentrations has been reported . The administration of canine IL‐31 to dogs resulted in a significant increase in pruritic behaviour .…”

Section: Discussionmentioning

confidence: 90%

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Alterations in circulating concentrations of IL‐17, IL‐31 and total IgE in dogs with atopic dermatitis

Chaudhary

Singh

Kumari

et al. 2019

Veterinary Dermatology

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Background -The pathogenesis of canine atopic dermatitis (AD) is complex. Dysregulation of the cutaneous immune system is considered to be an important part of the allergic response. Exploration of association of interleukin-17 (IL-17), IL-31, IgE and leukogram attributes with canine AD could provide novel insights into its immunopathology.Hypothesis/Objectives -To investigate possible associations of IL-17, IL-3, IgE and leukogram attributes of canine AD.Animals -17 dogs diagnosed with AD and six healthy dogs.Methods and materials -Circulating concentrations of IL-17, IL-31 and total IgE from sera samples were determined using commercial canine-specific quantitative immunoassay kits. Complete blood cell counts were analysed by an automated haematology analyser. Statistical differences between the two groups were determined using an unpaired t-test. The degree of relationship between the IL-17, IL-31, IgE, total leukocyte count (TLC) values and clinical signs scores (Canine Atopic Dermatitis Lesion Index and pruritus Visual Analog Scale pVAS) was determined by Pearson's r correlation statistic.Results -Dogs with AD had significantly (P < 0.0001) higher circulating concentrations of IL-17, IL-31 and total IgE compared with healthy dogs. Dogs with AD also had significantly higher TLC (P < 0.0002), absolute neutrophils (P < 0.0001) and absolute eosinophils (P < 0.0001) counts, and percentage of neutrophils (P < 0.03) and eosinophils (P < 0.0001) compared with healthy controls. A significant positive correlation (r 2 = 0.396; P < 0.007) between the pVAS and IL-31 was observed in dogs with AD.Conclusions and clinical importance -Marked elevation in circulating IL-17, IL-31 and total IgE along with the abnormalities in leukogram may be associated with canine AD and could be possible targets in the therapeutic management of canine AD.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 90%

Alterations in circulating concentrations of IL‐17, IL‐31 and total IgE in dogs with atopic dermatitis

Chaudhary

Singh

Kumari

et al. 2019

Veterinary Dermatology

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“…These results suggest that the Th2 response is increased and the Th1 response is decreased in the isolated PBMCs from AD dogs. Particularly, IL-31 (a TH2 cytokine) has attracted a lot of attention in recent years for its role in pruritus and atopic inflammation, and recent studies demonstrated serum IL-31 levels positively correlate with disease severity in both children and dogs with AD [50, 51]. Although total serum IgE levels are elevated in the humans with AD [52, 53], the values are of no clinical relevance in the AD dogs in this study, which is in agreement with previous reports [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Phosphodiesterase 4D, miR-203 and selected cytokines in the peripheral blood are associated with canine atopic dermatitis

et al. 2019

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Canine Atopic Dermatitis (AD) is a common complex and multifactorial disease involving immune dysregulation, genetic predisposition, skin barrier defects, environmental factors and allergic sensitization. To date, diagnosis of canine AD relies on a combination of patient history, clinical examination, allergy testing and response to diet trials/therapies with no reliable biomarkers available to distinguish AD from other diseases with similar clinical presentations. A handful of studies to identify potential biomarkers in the peripheral blood of AD dogs and healthy controls have been performed with some showing inconsistent and contradictory results. In this study, we, for the first time, report statistically significant increases in expression of phosphodiesterase 4D (PDE4D) gene in peripheral blood mononuclear cells (PBMCs) and miR-203 in plasma from AD dogs compared to healthy controls. In addition, we report a statistically non-significant change of the CD4 + /CD8 + ratio, a dramatic decrease of three gene markers (PIAS1, RORA and SH2B1) as well as a panel of differential expression of cytokines in AD dogs in comparison to the healthy controls. Our study provides important insight into the complexities of canine AD, and further studies to verify the specificity of these findings for canine AD at a larger-scale are warranted.

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“…Important role in atopic pruritus [167 ]. Its serum concentration correlates with the severity of active skin lesions [168 ]…”

Section: Canine Atopic Dermatitismentioning

confidence: 99%

Atopic dermatitis in cats and dogs: a difficult disease for animals and owners

Gedon

Mueller

2018

Clin Transl Allergy

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The purpose of this review article is to give an overview of atopic dermatitis in companion animals and of recent developments including knowledge on immunological background, novel treatment options and difficulties in disease management. The prevalence of hypersensitivities seems to be increasing. The pathogenetic mechanisms are not fully understood, yet multiple gene abnormalities and altered immunological processes are involved. In dogs and cats, the diagnosis of atopic dermatitis is based on history, clinical examination and exclusion of other differential diagnoses. Intradermal testing or testing for serum allergen-specific Immunoglobulin E is only used to identify allergens for inclusion in the extract for allergen immunotherapy. Symptomatic therapy includes glucocorticoids, ciclosporin, essential fatty acids and antihistamines. A selective janus kinase 1 inhibitor and a caninized monoclonal interleukin-31 antibody are the newest options for symptomatic treatment, although longterm effects still need to be assessed. The chronic and often severe nature of the disease, the costly diagnostic workup, frequent clinical flares and lifelong treatment are challenging for owners, pets and veterinarians. Patience and excellent communication skills are needed to achieve a good owner compliance and satisfactory clinical outcome for the animal.

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Investigation of the correlation of serum IL‐31 with severity of dermatitis in an experimental model of canine atopic dermatitis using beagle dogs

Cited by 17 publications

References 13 publications

Alterations in circulating concentrations of IL‐17, IL‐31 and total IgE in dogs with atopic dermatitis

Alterations in circulating concentrations of IL‐17, IL‐31 and total IgE in dogs with atopic dermatitis

Phosphodiesterase 4D, miR-203 and selected cytokines in the peripheral blood are associated with canine atopic dermatitis

Atopic dermatitis in cats and dogs: a difficult disease for animals and owners

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