The performance of partially hydrolyzed polyacrylamide (HPAM), which is the most commercially used polymer in drag reduction (DR) applications, is affected by several factors. These factors include Reynolds number, polymeric concentration, molecular weight, and, more importantly, salinity conditions, which can dramatically impact the polymeric structure and its behavior. In the current work, a deep analysis is done on the performance of HPAM at salinity levels mimicking industrial conditions by using an industrialscale fluid flow loop and a rotational rheometer. The impact of salinity on DR performance and degradation rates of HPAM was investigated at various molecular weights and a fixed concentration and then fitted with exponential decay models. Then, measurements of DR of the additives alone at different concentrations as well as blends of two saltresisting polymers, i.e., xanthan gum (XG) and poly(ethylene oxide) (PEO), were analyzed in tap water and in brine at different mass ratios. Our results showed that the presence of salts led to the drop of the DR of HPAM to almost half its value in tap water, while PEO was found to have an increase in the DR, and XG maintained nearly the same performance. The HPAM−XG mixtures had higher levels of improvement in both media and a slight improvement in the DR in brine over those of HPAM measurements alone. In the case of the HPAM−PEO mixture, the DR is substantially increased compared to HPAM alone. The results of this work confirm that conventional solutions, represented by the physical mixing of HPAM with inexpensive and environmentally friendly additives, are possible and can lead to a massive reduction in energy and freshwater consumption in industrial applications such as hydraulic fracturing.