As part of this study, the problems in ensuring regional environmental safety have been identified, the features of the development of environmental information systems have been considered. In order to solve the identified problems, the main existing analogues of the developed system have been analyzed. The structure of the information-analytical system to ensure environmental safety in the region has been proposed. It contains such main modules as waste, air, water, soil, plants, animals, as well as the blocks contained in each module: reference and information, reports, monitoring. The main functionality provided is described for each module and corresponding block. In addition, the main tasks aimed at the implementation of the developed information-analytical system for ensuring environmental safety of the region are formulated.