Investigation of the effect of anticoagulant usage in the flow diverter stent treatment of the patient-specific cerebral aneurysm using the Lagrangian coherent structures

Tercanlı, Muhammed Furkan; Olcay, Ali Bahadır; Mutlu, Onur; Bilgin, Cem; Hakyemez, Bahattin

doi:10.1016/j.jocn.2021.10.007

Cited by 3 publications

(1 citation statement)

References 32 publications

(48 reference statements)

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“…Nevertheless, it is imperative to recognize certain constraints inherent to our methodology. Primarily, the principal artery and aneurysm were presumed to be nondeformable entities; secondarily, the influence of anticoagulant usage 35 was not incorporated within our computational model. Lastly, the generalizability of our findings may be circumscribed by the singular patient profile utilized, although this approach does permit an in-depth analysis of FD selection effects in the context of an encased OA.…”

Section: Determination Of the Flow Diversion Rate At The Aneurysm Sitementioning

confidence: 99%

How Flow Diverter Selection Can Affect the Flow Changes within a Jailed Ophthalmic Artery: A Computational Fluid Dynamics Study

Ünsal,

Güçlü,

Olcay

et al. 2024

Asian J Neurosurg

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Introduction Flow diverter (FD) stents are widely used to treat giant aneurysms by reducing blood flow into the aneurysm sac. However, choosing the optimal FD for a patient can be challenging when a nearby artery, such as the ophthalmic artery (OA), is jailed by the FD placement. This study compares the impact of two FD stents with different effective metal surface area (EMSA) values on OA occlusion. Materials and Methods A numerical model of a 59-year-old female patient with a giant aneurysm in the left internal carotid artery and a jailed OA was created based on clinical data. Two FD stents, FRED4017 and FRED4518, with different EMSA values at the aneurysm neck and OA inlet, were virtually deployed in the model. Blood flow and occlusion amount in the OA were simulated and compared between the two FD stents. Results FRED4017 had higher EMSA values than FRED4518 at the aneurysm neck (35% vs. 24.6%) and lower EMSA values at the OA inlet (15% vs. 21.2%). FRED4017 caused more occlusion in the OA than FRED4518 (40% vs. 28%), indicating a higher risk of ocular ischemic syndrome. Conclusion The EMSA value of FD stents affects the blood flow and occlusion amount in the jailed OA. Therefore, selecting an FD stent with a low EMSA value at the OA inlet may be beneficial for patients with a nearby jailed artery at the aneurysm neck.

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Section: Determination Of the Flow Diversion Rate At The Aneurysm Sitementioning

confidence: 99%

How Flow Diverter Selection Can Affect the Flow Changes within a Jailed Ophthalmic Artery: A Computational Fluid Dynamics Study

Ünsal,

Güçlü,

Olcay

et al. 2024

Asian J Neurosurg

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Effect of the Effective Metal Surface Area of Two Different Flow Diverter Stents on the Stagnation Region Formation Inside the Aneurysm Sac

Gunaydin,

Guclu,

Olcay

et al. 2024

Asian J Neurosurg

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Objective Flow diversion (FD) is a relatively new technique for treating large, wide-necked, or fusiform aneurysms. Although FD is a more preferred option than coiling or clipping techniques in neurosurgery and neuroradiology clinics, the blood flow mechanism inside the aneurysm sac is not fully understood after the treatment. Besides, effective metal surface area (EMSA), a property of an FD related to porosity, shows variation at the patient's aneurysm neck by providing more or less blood flow inside an aneurysm sac than planned, causing nonstagnant or stagnant fluid region formation in the sac, respectively. Thus, the change in FD's EMSA can significantly affect the treatment's effectiveness, making even operation unsuccessful when variation in FD's EMSA at the aneurysm neck is overlooked. Materials and Methods In this study, a large aneurysm of a 52-year-old female patient was numerically investigated by virtually placing two commercially available FDs with different EMSA values one by one into the aneurysm-carrying artery. Results While FD stents at the aneurysm site substantially reduced the blood flow into the aneurysm, an FD with a 15.6% EMSA caused blood to flow in the aneurysm sac to have six times more kinetic energy than that of FD with a 29.5% EMSA. Conclusion Although FD's EMSA value demonstrated nearly up to 20% reduction at the patient's aneurysm neck based on a product catalog value, numerical model results revealed that the stagnated region's formation inside the aneurysm sac could be determined within a 9% difference based on digital subtraction angiography reformat image.

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Three-dimensional Lagrangian coherent structures in patients with aortic regurgitation

Abdallah,

Darwish,

Garcia

et al. 2024

Physics of Fluids

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Understanding blood transport in cardiovascular flows is important for managing patients with cardiovascular disease. In this study, three-dimensional Lagrangian coherent structures have been extracted for the first time in both healthy patients and patients with aortic regurgitation. To achieve this, a computationally efficient approach based on Lagrangian descriptors was employed with four-dimensional (4D) magnetic resonance imaging velocity fields. In healthy subjects, Lagrangian coherent structures analysis revealed well-defined mitral jet structures during early filling, directing flow toward ejection during systole. For patients with aortic regurgitation, complex flow structures included interactions between the mitral and regurgitant jets, indicating altered blood transport mechanisms. This study highlights the ability of Lagrangian descriptors to extract coherent structures from patient-specific 4D flow MRI data in a computationally efficient way. It also underscores the importance of extracting three-dimensional Lagrangian coherent structures to gain a better understanding of the complex interaction between the mitral inflow and the regurgitant jet.

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Investigation of the effect of anticoagulant usage in the flow diverter stent treatment of the patient-specific cerebral aneurysm using the Lagrangian coherent structures

Cited by 3 publications

References 32 publications

How Flow Diverter Selection Can Affect the Flow Changes within a Jailed Ophthalmic Artery: A Computational Fluid Dynamics Study

How Flow Diverter Selection Can Affect the Flow Changes within a Jailed Ophthalmic Artery: A Computational Fluid Dynamics Study

Effect of the Effective Metal Surface Area of Two Different Flow Diverter Stents on the Stagnation Region Formation Inside the Aneurysm Sac

Three-dimensional Lagrangian coherent structures in patients with aortic regurgitation

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