Investigation of the effect of copper status and therapy on fertility in beef suckler herds

Phillippo, M.; Humphries, W. R.; Lawrence, Catherine B.; Price, Jeremy J

doi:10.1017/s0021859600030148

Cited by 15 publications

(5 citation statements)

References 18 publications

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“…It has been demonstrated that parenteral Cu injection 1 month before the mating season increased plasma Cu levels but did not modify the reproductive performance [18]. In the present study, Cu administration 9 days before ovulation increased the pregnancy rate, suggesting that the beneficial effect of parenteral Cu injection could be related to the time of administration.…”

Section: Discussionsupporting

confidence: 39%

“…In the present study, the plasma Cu concentration of the animals used to evaluate pregnancy rate was below 89 µg/dL Cu (Experiment 4). (b) On the other hand, Cu could have a pharmacological effect on ovarian function and ovulation when applied parenterally, as suggested by Phillippo [18] and Underwood and Suttle [13]. In ruminants, FSH is the principal regulator of follicular growth, whereas LH stimulates large follicles [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Parenteral Copper Administration at the Beginning of a Fixed-Time Artificial Insemination Protocol in Beef Cattle: Effect on Ovarian Function and Pregnancy Rates

Anchordoquy

Lorenti

Polero³

et al. 2021

Biol Trace Elem Res

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The aim of this study was to evaluate the association between plasma copper (Cu) concentration and ovarian function during a fixed-time artificial insemination (FTAI) protocol and the effect of parenteral Cu administration (100 mg) at the start of such protocol (day 0) on area of preovulatory follicle (APF); area of corpus luteum (ACL), plasma estradiol (E2), and progesterone (P4) concentrations; CL blood flow (CLBF); and pregnancy rate in beef heifers and cows. In cows, plasma Cu concentration on days 0 and 7 correlated positively with APF. Copper administration increased plasma Cu concentration and decreased APF and plasma E2 concentration (day 9), without modifying ACL, plasma P4 concentration, and CLBF (day 16) in cows. Pregnancy rate was higher in Cu-supplemented cattle on day 41 after FTAI as compared with controls (58.76 and 45.28%, respectively). In conclusion, Cu administration at the beginning of the FTAI protocol increased pregnancy rate in beef heifers and cows, modifying APF and plasma E2 concentration in the latter.

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Section: Discussionsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Parenteral Copper Administration at the Beginning of a Fixed-Time Artificial Insemination Protocol in Beef Cattle: Effect on Ovarian Function and Pregnancy Rates

Anchordoquy

Lorenti

Polero³

et al. 2021

Biol Trace Elem Res

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“…There are differing reports in the literature on the effect of low copper (Cu) status on reproduction in cattle. While Cu status was thought to be positively related to reproductive performance in cattle (Bennetts, Beck & Harley, 1948), other reports do not substantiate this (Littlejohn & Lewis, 1960;Seekles & Claessens, 1967;Rowlands, Little & Kitchenham, 1977;Larson, Marbruck & Lowry, 1980;Phillippo et al 1982). Though a positive effect of Cu supplementation on fertility has been claimed under certain circumstances (Blakemore & Venn, 1950;Munro, 1957;Mahadevan & Zubairy, 1969;Sastry et al 1973;Pickering, 1975;Hunter, 1977), no beneficial effect has been reported from controlled trials on an individual farm basis (Poole & Walshe, 1970;Whitaker, 1982;Phillippo et al 1982).…”

Section: Introductionmentioning

confidence: 99%

“…Although recent work (Phillippo et al 1982) supported the idea that fertility was not related to Cu status and was not improved by Cu treatment, it also indicated that high molybdenum (Mo) intake might be involved in poor reproductive performance. Earlier work had suggested such a relationship.…”

Section: Introductionmentioning

confidence: 99%

The effect of dietary molybdenum and iron on copper status, puberty, fertility and oestrous cycles in cattle

Phillippo¹,

Humphries²,

Atkinson³

et al. 1987

J. Agric. Sci.

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103

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Two experiments were conducted to examine the effects of supplementation of a control diet of barley grain and barley straw containing 4 mg copper (Cu)/kg dry matter (D.M.) either with 5 mg molybdenum (Mo)/kg D.M. or with 500 or 800 mg iron (Fe)/kg D.M. on puberty, fertility and oestrous cycles of cattle. Puberty occurred normally in control, Fesupplemented and control animals on a restricted intake whereas it was delayed by 12 and 8 weeks respectively by Mo supplementation. This effect of Mo was not due to the low Cu status since this was equally low in the Fe-supplemented animals, nor was it due to the reduced growth rate since puberty occurred normally in control animals that had a similar live-weight gain. A significant reduction in the pulsatile release of luteinizing hormone was observed within 11 weeks of the Mo supplementation and before any of the other clinical signs were evident, suggesting that Mo may be affecting puberty by altering the release of luteinizing hormone either directly or indirectly.Mo supplementation significantly reduced the percentage conception rate to 12-33% compared with 57-80% in control and Fe-supplemented animals. This effect was not dependent on the rate of live-weight gain which was standardized across the different treatments at approximately 0 -6 kg/day. Within 12 weeks of the replacement of dietary Fe by Mo a lower conception rate occurred; replacing dietary Mo by Fe led to a normal conception rate within 12 weeks without any accompanying changes in Cu status or in the rate of live-weight gain. The plasma Mo concentrations, however, changed significantly during these alterations in dietary supplementation. The pre-ovulatory peak height of luteinizing hormone was significantly lower in animals on the Mo-supplemented diet compared with control and Fe-supplemented animals, but the administration of LHRH did not alter the conception rate.More Mo-supplemented animals failed to ovulate following prostaglandin induced synchronization in comparison with the other treatments, and by the 84th week a significantly greater number of Mo-supplemented animals (12/18) had become anoestrous compared with the other groups (2/30). Cu repletion of these anoestrous Mo animals for a period of 20 weeks did not result in resumption of normal oestrous cycles, but ovulation and oestrus were induced by progesterone and LHRH treatment. Results in the latter part of the study indicated that Mo caused superovulation.These data show that Mo supplementation delayed the onset of puberty, decreased the conception rate and caused anovulation and anoestrus in cattle without accompanying changes in Cu status or in live-weight gain. It is suggested that these effects of Mo are associated with a decreased release of luteinizing hormone that might be due to an altered ovarian steroid secretion.

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“…Altos niveles de molibdeno dietario en rumiantes pueden ocasionar, por sí mismos o a través de su interacción sobre el metabolismo del cobre, diversos trastornos, entre ellos reproductivos, tanto en machos como en hembras 2,3,9,10,13,14 . La molibdenosis es también conocida con el nombre de hipocuprosis secundaria, deficiencia secundaria de cobre o deficiencia condicionada de cobre.…”

Section: Introductionunclassified

Acción tóxica del tetratiomolibdato de amonio sobre el tejido testicular en ratas

Trulls

Brem

Negrette³

et al. 2008

Rev. vet.

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<p>La acción tóxica del molibdeno, por sí mismo o por su interacción con el metabolismo del cobre, podría ocasionar trastornos sobre diversos tejidos. Con el fin de provocar una deficiencia secundaria de cobre, se procedió al agregado de tetratiomolibdato de amonio (TTMo) en la dieta de ratas, para evaluar sus efectos sobre la función reproductiva. En rumiantes, la toxicidad del Mo es provocada por la formación de tetratiomolibdatos por la microflora ruminal. Con este producto sintetizado in vitro, se pudo reproducir la enfermedad en ratas que, como el resto de los monogástricos, son particularmente resistentes a la intoxicación natural del Mo por carecer del ambiente digestivo adecuado para dicha transformación. Para lograr el objetivo propuesto, se valoró la respuesta de la testosterona tras el estímulo de gonadorrelinas (GnRH) y mediante estudios anatomohistopatológicos se determinó la integridad estructural del tejido testicular. Se utilizaron 40 ratas de sexo macho de la cepa Wistar, de 3 meses de edad; los grupos tratados recibieron durante 120 días dosis de 3 mg de TTMo/100 ml de agua de bebida. En este ensayo de molibdenosis experimental se logró una sintomatología clínica y bioquímica compatible con una deficiencia secundaria de cobre. Las diferencias entre grupos tratados y testigos en la respuesta de testosterona después de la inyección de GnRH, fueron significativas, indicando una función endocrina comprometida. Los ejemplares tratados revelaron disminución del tamaño testicular, túbulos seminíferos con fenómenos degenerativos del epitelio germinal, necrosis y desaparición de espermátides y espermatozoides. Algunos testículos presentaban únicamente espermatogonias y células de Sertoli con fenómenos de vacuolización citoplasmática, picnosis nuclear y<br />células gigantes fagocíticas multinucleadas. Las lesiones en el tejido intersticial se caracterizaron por fibrosis leve y depleción de células intersticiales de Leydig.</p>

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Investigation of the effect of copper status and therapy on fertility in beef suckler herds

Abstract: A survey on 17 beef suckler herds in the north-east of Scotland showed that there was no relationship between herd serum copper concentration (range 0-16-0-92

Cited by 15 publications

References 18 publications

Parenteral Copper Administration at the Beginning of a Fixed-Time Artificial Insemination Protocol in Beef Cattle: Effect on Ovarian Function and Pregnancy Rates

Parenteral Copper Administration at the Beginning of a Fixed-Time Artificial Insemination Protocol in Beef Cattle: Effect on Ovarian Function and Pregnancy Rates

The effect of dietary molybdenum and iron on copper status, puberty, fertility and oestrous cycles in cattle

Acción tóxica del tetratiomolibdato de amonio sobre el tejido testicular en ratas

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