Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

Manwar, Rayyan; Kratkiewicz, Karl; Avanaki, Kamran

doi:10.3390/s20154189

Cited by 36 publications

(25 citation statements)

References 83 publications

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“…One study evaluated distortion by imaging a square loop target embedded in a brain-mimicking gelatin phantom beneath ex vivo ovine skull. 133 Distortion due to poor image acquisition settings may be corrected or calibrated, but tissue effects cannot always be avoided or completely mitigated. Especially in the latter scenario, distortion should be included in photoacoustic image quality testing.…”

Section: Current Image Quality Evaluation Practices In Photoacoustic Imagingmentioning

confidence: 99%

Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment

et al. 2021

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. Significance : Photoacoustic imaging (PAI) is a powerful emerging technology with broad clinical applications, but consensus test methods are needed to standardize performance evaluation and accelerate translation. Aim : To review consensus image quality test methods for mature imaging modalities [ultrasound, magnetic resonance imaging (MRI), x-ray CT, and x-ray mammography], identify best practices in phantom design and testing procedures, and compare against current practices in PAI phantom testing. Approach : We reviewed scientific papers, international standards, clinical accreditation guidelines, and professional society recommendations describing medical image quality test methods. Observations are organized by image quality characteristics (IQCs), including spatial resolution, geometric accuracy, imaging depth, uniformity, sensitivity, low-contrast detectability, and artifacts. Results : Consensus documents typically prescribed phantom geometry and material property requirements, as well as specific data acquisition and analysis protocols to optimize test consistency and reproducibility. While these documents considered a wide array of IQCs, reported PAI phantom testing focused heavily on in-plane resolution, depth of visualization, and sensitivity. Understudied IQCs that merit further consideration include out-of-plane resolution, geometric accuracy, uniformity, low-contrast detectability, and co-registration accuracy. Conclusions : Available medical image quality standards provide a blueprint for establishing consensus best practices for photoacoustic image quality assessment and thus hastening PAI technology advancement, translation, and clinical adoption.

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Section: Current Image Quality Evaluation Practices In Photoacoustic Imagingmentioning

confidence: 99%

Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment

et al. 2021

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“…PA imaging has been previously applied for breast cancer, melanoma, osteoarthritis imaging, cerebral blood oxygen saturation assessment, and neuro-vasculature evaluation with and without functional hemodynamics [131][132][133][134]. Like US imaging, a major challenge in PA imaging of the brain is that the skull limits the penetration depth and causes image distortions due to acoustic aberrations [135,136]. However, fetuses and neonates are more suitable for PA imaging due to their relatively thin skull and open fontanelles [137][138][139][140].…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Methods for Monitoring Risk of Hypoxic Damage in Fetal and Neonatal Brains: A Review

et al. 2021

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Fetal, perinatal, and neonatal asphyxia are vital health issues for the most vulnerable groups in human beings, including fetuses, newborns, and infants. Severe reduction in oxygen and blood supply to the fetal brain can cause hypoxic-ischemic encephalopathy, leading to long-term neurological disorders, including mental impairment and cerebral palsy. Such neurological disorders are major healthcare concerns. Therefore, there has been a continuous effort to develop clinically useful diagnostic tools for accurately and quantitatively measuring and monitoring blood and oxygen supply to the fetal and neonatal brain to avoid severe consequences of asphyxia Hypoxic-Ischemic Encephalopathy (HIE) and Neonatal Encephalopathy (NE). Major diagnostic technologies used for this purpose include fetal heart rate monitoring (FHRM), fetus scalp blood sampling (FBS), ultrasound (US) imaging, magnetic resonance imaging (MRI), x-ray computed tomography (CT), and nuclear medicine. In addition, given the limitations and shortcomings of traditional diagnostic methods, emerging technologies such as near-infrared spectroscopy (NIRS) and photoacoustic (PA) imaging have also been introduced as stand-alone or complementary solutions to address this critical gap in fetal and neonatal care. This review provides a thorough overview of the traditional and emerging technologies for monitoring fetal and neonatal brain oxygenation status and describes their clinical utility, performance, advantages, and disadvantages.

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“…Acoustic sensing is based on the transmission and reception of acoustic pressure waves. Acoustic sensors are used to receive acoustic waves induced by the transmitted ultrasound (e.g., ultrasound transducers) or electromagnetic waves (e.g., in electroacoustic [ 8 , 9 ], magnetoacoustic [ 10 , 11 ], thermoacoustic [ 12 , 13 ], photoacoustic [ 7 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], X-ray acoustic [ 34 , 35 ], and proton-acoustic [ 36 , 37 ] modalities) (see Figure 1 ). Acoustic biosensors employ, for instance, the piezoelectric effect to excite acoustic waves electrically to an input transducer and to receive waves at the output transducer.…”

Section: Introductionmentioning

confidence: 99%

Couplants in Acoustic Biosensing Systems

Manwar

Avanaki

2022

Chemosensors

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Acoustic biosensors are widely used in physical, chemical, and biosensing applications. One of the major concerns in acoustic biosensing is the delicacy of the medium through which acoustic waves propagate and reach acoustic sensors. Even a small airgap diminishes acoustic signal strengths due to high acoustic impedance mismatch. Therefore, the presence of a coupling medium to create a pathway for an efficient propagation of acoustic waves is essential. Here, we have reviewed the chemical, physical, and acoustic characteristics of various coupling material (liquid, gel-based, semi-dry, and dry) and present a guide to determine a suitable application-specific coupling medium.

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Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

Cited by 36 publications

References 83 publications

Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment

Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment

Methods for Monitoring Risk of Hypoxic Damage in Fetal and Neonatal Brains: A Review

Couplants in Acoustic Biosensing Systems

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