Background: As mobile phones have become essential in daily life, concerns have arisen about their overuse and the emergence of mobile phone addiction. Research indicates that excessive mobile phone use can contribute to a variety of health problems, including cognitive impairments, visual disturbances, hand discomfort, and fatigue. This study investigated the impact of mobile phone addiction on various health parameters, including cognitive status, eye health, hand discomfort, and fatigue, among university students. A total of 293 students participated in the study. Methods: Students mobile phone addiction status was assessed via the Smartphone Addiction Scale-Short Version (SAS-SV). The students were divided into two groups according to the cutoff values given in the study: the "addicted group(n:142) (SAS-SV value man>31, woman>33)", consisting of those determined to have mobile phone addiction, and the "control group (n:151)", consisting of those nonaddictive tendencies. The Chalder Fatigue Scale for fatigue evaluation, the Cognitive Failures Questionnaire for cognitive status, the Cornell Hand Discomfort Questionnaire for hand discomfort, and the Ocular Surface Disease Index for eye dryness were used. Data were collected online via Google Forms following ethics committee approval. Results: The addicted group presented higher scores on the Cognitive Failures Questionnaire, indicating poorer cognitive performance(p<0.001). Additionally, significant differences were observed in fatigue levels (p=0.014), and eye health(p=0.002). Notably, hand discomfort was significant in specific zones of the right hand (p<0,05). However, no significant differences were found in other regions of the hand(p>0,05). Conclusions:These findings underscore the adverse health effects associated with mobile phone addiction, highlighting the need for awareness and potential interventions among university students.