2018
DOI: 10.5152/tud.2017.95752
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Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

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Cited by 20 publications
(24 citation statements)
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“…The histopathological examination of the testicular tissue after CDDP injection showed irregularities in seminiferous tubules, apoptosis, and necrosis in interstitial cells of Leydig, and degenerative changes in germ cells. These findings were observed also in other studies 1,3,4,16,29 confirming the cytotoxic effect of CDDP.…”
Section: Discussionsupporting
confidence: 87%
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“…The histopathological examination of the testicular tissue after CDDP injection showed irregularities in seminiferous tubules, apoptosis, and necrosis in interstitial cells of Leydig, and degenerative changes in germ cells. These findings were observed also in other studies 1,3,4,16,29 confirming the cytotoxic effect of CDDP.…”
Section: Discussionsupporting
confidence: 87%
“…These findings were in coupe with other studies that showed a marked increase in immunostaining intensity of caspase-3 in CDDP group and decreased intensity in control group. 16,45 The CDDP induces the Bax translocation to mitochondria releasing ROS and cytochrome c which then stimulates caspases 3,8,9 triggering apoptosis. 44 Caspase-3 is the executive caspase that induces apoptosis and its activation by CDDP confirmed the CDDP apoptotic damage in the testicular tissue.…”
Section: Discussionmentioning
confidence: 99%
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“…The high polyunsaturated membrane lipid content of the testes makes the testes more susceptible to the effects of oxidative agents such as CP (Gevrek & Erdemir, ). The protective effect of various natural substances, including fish oil (Ciftci et al, ), curcumin (Gevrek & Erdemir, ), resveratrol (Reddy et al, ), hesperidin (Kaya et al, ) and rutin (Aksu et al, ), against CP‐induced reproductive system damage has also been demonstrated in many studies. To our knowledge, the potential beneficial effects of β‐glucans against CP‐induced reproductive toxicity have not been studied previously.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies demonstrated that Cis inhibits tumor growth by inducing apoptosis in patients [30] and Cis induces apoptosis in rat testis and spermatozoa [31][32][33]. Several studies showed that Cis treatment increases the formation of oxidative stress, DNA fragmentation and induceses apoptosis in testis, and different antioxidants and antioxidant rich extracts such as rutin [34], Ginkgo biloba extract [27], and Eugenia jambolana extract [35] inhibits apoptosis in Cis induced testis damage.…”
Section: Discussionmentioning
confidence: 99%