Investigation of the effects of Toxoplasma gondii on behavioral and molecular mechanism in bradyzoite stage

Akcay, Guven; Bahadir, Anzel; Tatar, Yakup; Nuri Atalar, Mehmet; Babur, Cahit; Taylan Ozkan, Aysegul

doi:10.1016/j.brainres.2024.148762

Brain Research

2024

DOI: 10.1016/j.brainres.2024.148762

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Investigation of the effects of Toxoplasma gondii on behavioral and molecular mechanism in bradyzoite stage

Guven Akcay,

Anzel Bahadir,

Yakup Tatar

et al.

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2024

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Cited by 2 publications

References 36 publications

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Animal Experiments Used in Experimental Neuroscience Research: Learning, Memory, Anxiety, Depression and Motor Function Behavioural Experiments

Akçay

2024

Düzce Tıp Fakültesi Dergisi

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Behavioral experiments have been conducted since the classical conditioning research of Ivan Pavlov in 1904. Experimental research plays an important role in understanding the mechanisms of diseases, preventing these diseases, and developing effective treatment methods. Research using animal models is very important to understand the mechanisms of these diseases and to develop effective treatment strategies. Animal models are widely used in the research of a treatment method, the development of novel treatment protocols, and the discovery of new drug molecules. The efficacy of the drug to be developed is very important both for testing whether the animal model is formed before starting the research and for the effectiveness of the drug in treatment and for the elucidation of the mechanisms to be investigated. Therefore, evaluations are usually made with behavioral experiments. Each behavioral experiment has its own advantages and disadvantages. Therefore, the researcher should be aware of these advantages and limitations before choosing the most appropriate behavioral experiment. This review aimed to describe the most commonly used learning, memory, anxiety, depression, and motor function behavioral experimental protocols in experimental models such as Alzheimer's, epilepsy, migraine, neuropathic pain, schizophrenia, Parkinson's, cerebral ischemia, and traumatic brain injury.

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Animal Experiments Used in Experimental Neuroscience Research: Learning, Memory, Anxiety, Depression and Motor Function Behavioural Experiments

Akçay

2024

Düzce Tıp Fakültesi Dergisi

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Current vaccine candidate of toxoplasmosis

WOLDEGERIMA,

GETACHEW,

MISGANAW

et al. 2024

JLSB

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Toxoplasma gondii is an intracellular protozoan parasite belonging from the phylum Apicomplexa, known for causing toxoplasmosis. The disease has a global presence, affecting about one-third of the world’s population. The parasite infects various intermediate hosts, including humans and other warm-blooded mammals, with cats serving as the definitive hosts. Its life cycle is complex, featuring a sexual phase in the definitive host and an asexual phase in intermediate hosts. Toxoplasmosis can leads severe neurologic, ocular, and systemic diseases in neonates and immunocompromised individuals. In immunocompetent individuals, the infection is typically asymptomatic, forming dormant tissue cysts in immune-privileged sites such as the muscles and brain. During pregnancy, toxoplasmosis poses significant health risks, potentially causing severe birth defects or miscarriage, and a major concern for immunocompromised hosts. Current control measures are inadequate, highlighting the need for effective vaccines. The initial host defense against T. gondii occurs at the intestinal mucosa, where cytokines and chemokines released by intestinal epithelial cells facilitate the migration of inflammatory cells, including macrophages, neutrophils, and dendritic cells. Developing a vaccine that can enhance this mucosal immunity is crucial for preventing toxoplasmosis. Therefore, the development of vaccines against T.gondii is a promising alternative mechanism to prevent toxoplasmosis. This review aims to present the current status of vaccine candidates against Toxoplasma gondii.

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Investigation of the effects of Toxoplasma gondii on behavioral and molecular mechanism in bradyzoite stage

Cited by 2 publications

References 36 publications

Animal Experiments Used in Experimental Neuroscience Research: Learning, Memory, Anxiety, Depression and Motor Function Behavioural Experiments

Animal Experiments Used in Experimental Neuroscience Research: Learning, Memory, Anxiety, Depression and Motor Function Behavioural Experiments

Current vaccine candidate of toxoplasmosis

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