Investigation of the effects of cannabidiol on vacuous chewing movements, locomotion, oxidative stress and blood glucose in rats treated with oral haloperidol

Effects of Cannabidiol on Locomotor Activity

“…Data from behavioral tests were accompanied by CBD reducing the effects of hyperglycemia induced by haloperidol. Furthermore, in the same group of experiments, the administration of CBD alone was associated with antioxidant activity because increased brain α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging activity was detected [ 75 ]. These experiments indicate that CBD can improve motor deficits induced by haloperidol and suggest that this cannabinoid deserves to be investigated as a useful agent to protect from extrapyramidal side effects and long-term movement disorders induced by antipsychotic drugs.…”

“… This effect was slightly reduced by concomitant CBD/haloperidol administration. [ 75 ] Haloperidol reduced motor activity. CBD (5 mg/kg) antagonized hypolocomotion induced by haloperidol.…”

“…These beneficial effects are corroborated by evidence that CBD changes the conductance of voltage-dependent anion channel 1, involved in the pathophysiology of movement disorders [ 82 ]. CBD is also implicated in the activation and upregulation of PPARγ, a receptor known to be associated with the appearance of oral dyskinesia [ 75 ]. Moreover, CBD also showed potential antidepressant effects without any changes in locomotor activity [ 79 ], thus suggesting the possibility of using CBD in these diseases without concern for motor activity.…”

Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies

“…On the contrary, IL-10 is decreased, due to its role as an anti-inflammatory cytokine ( Peroza et al, 2016 ; Sonego et al, 2018 ). Consequently, some agents with antioxidative and anti-inflammatory properties were tested as potential drugs for TD, such as resveratrol ( Busanello et al, 2012 , Busanello et al, 2017 ), vitamin E ( An et al, 2016 ; Shi et al, 2016 ), lycopene ( Datta et al, 2016 ), L-theanine ( Chen et al, 2018 ; Soung et al, 2018 ; Tsai et al, 2019 ), cannabidiol ( Sonego et al, 2018 ; Kajero et al, 2020 ), and catechin ( Wang et al, 2015 ; Reinheimer et al, 2020 ). Additionally, several different plant-based compounds were tested ( Patil et al, 2012 ; Sekiguchi et al, 2012 ; An et al, 2013 ; An et al, 2016 ; Shi et al, 2016 ; Samad and Haleem 2017 ; Dhingra et al, 2018 ; Wang et al, 2021a ).…”

Effects of cannabidiol on weight and fasting blood sugar with chronic and subchronic haloperidol administration

“…Effective doses of CBD in rats range between 2.5 and 10 mg/kg/day [24]. We opted for 5 mg/kg of CBD, using our previous experiments as a guide [25].…”