Investigation of the efficacy of alcohol-based solutions on adenovirus serotypes 8, 19 and 37, common causes of epidemic keratoconjunctivitis, after an adenovirus outbreak in hospital

Uzuner, Hüseyin; Karadenizli, Aynur; Er, Doğanhan Kadir; Osmani, Agim

doi:10.1016/j.jhin.2018.05.011

Cited by 24 publications

(19 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Influenza, RSV, and hMPV are also enveloped viruses and can be expected to be inactivated by alcohol [27]. However, adenovirus, as a non-enveloped virus, is generally considered to be more resistant to disinfectants including alcohol [27,28]. It may therefore be difficult to control adenovirus (respiratory infection) with the current infection control measures for COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019

Fukuda

Tsugawa

Nagaoka

et al. 2021

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Introduction The epidemic of coronavirus disease 2019 (COVID-19) rapidly spread worldwide, and the various infection control measures have a significant influence on the spread of many infectious diseases. However, there have been no multicenter studies on how the number of hospitalized children with various infectious diseases changed before and after the outbreak of COVID-19 in Japan. Methods We conducted a multicenter, prospective survey for hospitalized pediatric patients in 18 hospitals in Hokkaido Prefecture, Japan, from July 2019 to February 2021. We defined July 2019 to February 2020 as pre-COVID-19, and July 2020 to February 2021 as post-COVID-19. We surveyed various infectious diseases by sex and age. Results In total, 5,300 patients were hospitalized during the study period. The number of patients decreased from 4,266 in the pre-COVID-19 period to 701 (16.4%) post-COVID-19. Patients with influenza and RSV decreased from 308 and 795 pre-COVID-19 to zero and three (0.4%) post-COVID-19. However, patients with adenovirus (respiratory infection) only decreased to 60.9% (46 to 28) of pre-COVID levels. Patients with rotavirus, norovirus, and adenovirus gastroenteritis decreased markedly post-COVID-19 to 2.6% (38 to 1), 27.8% (97 to 27) and 13.5% (37 to 5). The number of patients with UTIs was similar across the two periods (109 and 90). KD patients decreased to 31.7% (161 to 51) post-COVID-19. Conclusions We suggest that current infection control measures for COVID-19 such as wearing masks, washing hands, and disinfecting hands with alcohol are effective against various infectious diseases. However, these effects vary by disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019

Fukuda

Tsugawa

Nagaoka

et al. 2021

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

show abstract

“…Alcohol and quaternary ammonium salt disinfectants lack sufficient disinfection and inactivation effects on some subtypes of adenovirus (9). While ophthalmoscopy, the lens needs to be in direct contact with the patient's cornea and conjunctiva, and henceforth, the disinfection of the lens must be safe for the cornea and conjunctiva and also should not damage the lens.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Blocking the Prevalence of Adenoviral Conjunctivitis in Premature Infants by a Combined Disinfection Method

Wang

Jin

et al. 2022

Jpn J Infect Dis

View full text Add to dashboard Cite

This study aimed to determine the cause behind the outbreak of nosocomial adenoviral conjunctivitis in the Neonatal Intensive Care Unit (NICU) and the impact of infection control measures. The objectives of the present study include investigation of the hospital-borne infection associated with adenoviral conjunctivitis, analysis of the possible risk factors, setting bundle infection control measures, which were adjusted according to the control effect. The present study also aims to observe the effect of different intervention measures on controlling adenoviral conjunctivitis. During the first and second intervention periods, overall 635 and 597 NICU patients were enrolled, respectively. Ophthalmoscopy was conducted among 188 (in the first intervention) and 184 (in the second intervention) patients (P>0.05). The times of ophthalmoscopy the patients received were 417 and 457 (P<0.001). During the first intervention, 13 patients suffered from adenoviral conjunctivitis, while no patients with adenoviral conjunctivitis were found during the second intervention (P<0.001). All adenoviral conjunctivitis cases were reported 6-27 days (mean 12 days) after ophthalmoscopy. The hydrogen peroxide disinfection bundle measures can effectively restrict the prevalence of adenoviral conjunctivitis associated with ophthalmoscopy in premature infants.

show abstract

“…https://www.cen.eu/Pages/default.aspx) EN 14476 (Chemical disinfectants and antiseptics) and previously described methods (24,29), a modified assay was performed as follows.…”

Section: Evaluation Of Anti-adenoviral Activity Of Altantmentioning

confidence: 99%

“…The drug susceptibilities for different types of HAdV varies according to the type of HAdV (22,24) and should be tested using clinically important types of HAdV. HAdV is highly resistant to common hand sanitizers such as ethanol (2,3,(22)(23)(24). Ozone is a strong oxidizer and exhibits a very high potency and disinfecting efficacy.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Evaluation of the Anti-Adenoviral Activity of ALTANT, an Ozonated Alcohol Disinfectant

et al. 2020

View full text Add to dashboard Cite

Seven species (A-G) of human mastadenovirus (HAdV) are known, and more than 100 types have been reported. HAdV is highly resistant to common hand sanitizers. Epidemic keratoconjunctivitis and pharyngoconjunctival fever caused by HAdV can be explosively transmitted in a confined space, resulting in outbreaks such as nosocomial infections.Given the absence of an antiviral agent for HAdV infection, it is important to prevent the spread of infection using disinfectants. The bactericidal and virucidal activities of ozone have already been known widely. ALTANT is an ozonated alcohol preparation developed by E-TECH Co., Ltd.

show abstract

Investigation of the efficacy of alcohol-based solutions on adenovirus serotypes 8, 19 and 37, common causes of epidemic keratoconjunctivitis, after an adenovirus outbreak in hospital

Cited by 24 publications

References 40 publications

Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019

Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019

Blocking the Prevalence of Adenoviral Conjunctivitis in Premature Infants by a Combined Disinfection Method

Evaluation of the Anti-Adenoviral Activity of ALTANT, an Ozonated Alcohol Disinfectant

Contact Info

Product

Resources

About