Investigation of the feeding effects of melanin concentrating hormone on food intake — action independent of galanin and the melanocortin receptors

Rossi, Michela; Beak, Sarah A.; Choi, S. J.; Small, Caroline J.; Morgan, David; Ghatei, Mohammad A.; Smith, David M.; Bloom, Stephen R.

doi:10.1016/s0006-8993(99)02005-3

Cited by 88 publications

(37 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NPY, the most potent orexigenic peptide yet discovered, has its maximal effect when administered into the perifornical area just latero-caudal to the PVN (22). Several other peptides have also been shown to alter feeding when directly injected into the PVN, including galanin, melanin-concentrating hormone, and orexin-A (23)(24)(25). Recently, Giraudo et al (26) demonstrated the effects of SHU9119 and MT II, a melanocortin 3/4 receptor antagonist and agonist, respect i v e l y, on feeding when injected into the PVN.…”

Section: Discussionmentioning

confidence: 99%

Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.

et al. 2000

View full text Add to dashboard Cite

The melanocortin-4 receptor (MC4R) in the hypothalamus is thought to be important in physiological regulation of food intake. We investigated which hypothalamic areas known to express MC4R are involved in the regulation of feeding by using -m e l a n o c y t e -s t i m u l a ting hormone ( -MSH), an endogenous MC4R agonist, and agouti-related peptide (Agrp), an endogenous MC4R antagonist. Cannulae were inserted into the rat hypothalamic paraventricular (

show abstract

Section: Discussionmentioning

confidence: 99%

Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Zhang and van den Pol found that in addition to reducing intake, body weight and sleep, central injections of TRH also inhibited melaninconcentrating hormone (MCH) neurons. MCH neurons increase food intake (64).…”

Section: Thyrotropin Releasing Hormonementioning

confidence: 99%

Effects of sugar solutions on hypothalamic appetite regulation

Colley¹,

Castonguay²

2015

Physiology & Behavior

View full text Add to dashboard Cite

There are multiple hypotheses for the causes of the obesity epidemic. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine some the unique metabolic changes that occur with initial exposure to dilute glucose, sucrose, high fructose corn syrup, or fructose solutions. Rats were given access to food, water and a sugar solution for 24 h, after which blood and tissues were collected. Fructose access (as opposed to other sugars investigated) resulted in a doubling of circulating triglycerides. Glucose consumption resulted in upregulation of 7 satiety related hypothalamic peptides whereas changes in gene expression were mixed for remaining sugars. Also, following multiple verification assays, 6 satiety related peptides were verified as being affected by sugar intake. These data provide evidence that not all sugars are equally effective in affecting the control of intake.

show abstract

“…In this respect, intraventricular administration of the agonist ␣-MSH suppresses feeding (1)(2)(3)(4). Moreover, MC4R knock-out in mice leads to obesity syndrome with hyperphagia, hyperglycemia, and hyperinsulinemia (5).…”

Section: Mc4rmentioning

confidence: 99%

Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH)

McDaniel

Molden

Mohammad

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: MC4R is essential for energy homeostasis and cycles continuously. Results: MC4R internalization is blocked by clathrin and cholesterol depletion, reducing receptor response to ␣-MSH, which is partially recovered by mutations at Thr-312/Ser-329. Conclusion: Constitutive internalization of MC4R is cholesterol-dependent and required for receptor function. Significance: These findings provide a potentially novel mechanism by which hypothalamic cell cholesterol content can affect appetite control.

show abstract

Investigation of the feeding effects of melanin concentrating hormone on food intake — action independent of galanin and the melanocortin receptors

Cited by 88 publications

References 34 publications

Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.

Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.

Effects of sugar solutions on hypothalamic appetite regulation

Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH)

Contact Info

Product

Resources

About