Investigation of the fluorescence of benoxinate for facile determination in pure form, eye drops and aqueous humor

Sustainable production of active pharmaceutical ingredients from lignin-based benzoic acid derivatives via “demand orientation”

“…2-Diethylaminoethyl 4-amino-3-butoxy-benzoate, known as benoxinate or oxybuprocaine, with the molecular formula C 17 H 28 N 2 O 3 , is an amino benzoate used as a local anesthetic. 152 As a topical agent, oxybuprocaine can be made into gels or solutions for surface anesthesia and lubrication during surgery. Moreover, oxybuprocaine is widely used in the ear, nose, and throat (ENT) department and ophthalmology, since it is less irritating to the conjunctiva and has few adverse effects.…”

“…Moreover, oxybuprocaine is widely used in the ear, nose, and throat (ENT) department and ophthalmology, since it is less irritating to the conjunctiva and has few adverse effects. 152,153 Compared with other anesthetic drugs, oxybuprocaine is more potent, has a longer effective time, and produces a slower drop in arterial blood pressure and heart rate at the same dose. 154,155 Makra's team found that an oxybuprocaine concentration of 0.2% when administered by injection provided similar anesthetic effects to the 2% concentration of lidocaine that is commonly used in the clinic.…”

A sustainable sensitive spectrofluorimetric approach for the determination of the multipotent protein lactoferrin in different pharmaceuticals and infant milk formula: Compliance with greenness metrics

“…The spectrofluorimetric technique has proved to be a facile analytical tool for the determination of many pharmaceutical and biomedical products [21][22][23][24][25][26][27][28][29][30]. Because spectrofluorimetry is an easy, inexpensive, sensitive, and selective method that allows the detection of low concentrations of the tested analyte, the aim of the current study was to present a novel spectrofluorimetric approach for the quantitation of lactoferrin in different pharmaceuticals and milk powder samples.…”