Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine

Saghir, Shakil A.; Brzak, Kathy A.; Markham, Dan A.; Bartels, Michael; Stott, William T.

doi:10.1016/j.yrtph.2005.04.002

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…N-Nitrosodiethanolamine formation from diethanolamine (>99% purity) and nitrite was also examined in another study. 31 Female B6C3F 1 mice were dosed dermally or orally with 4 mg/ kg diethanolamine, in conjunction with oral exposure to sodium nitrite. Following 7 days of dermal dosing, no NDELA was detected in the blood, ingesta, or urine of test, vehicle control, or sodium nitrite control mice.…”

Section: N-nitrosodiethanolamine Formationmentioning

confidence: 99%

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics

et al. 2017

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The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports. Since data were not available for each individual ingredient, and since the salts dissociate freely in water, the Panel extrapolated from previous reports to support safety. The Panel concluded that diethanolamine and its salts are safe for use when formulated to be nonirritating. These ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.

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Section: N-nitrosodiethanolamine Formationmentioning

confidence: 99%

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics

et al. 2017

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“…The formation of a specific nitrosamine, NDELA, from reaction of TEA with nitrite was examined in vitro and in vivo. 12 The TEA used in these studies had an impurity content of 0.4% diethanolamine. In an aq matrix, approximately 3% TEA was converted to NDELA at a pH of 4.0 in the presence of acetic acid.…”

Section: Introductionmentioning

confidence: 99%

“…In vivo, female B6C3F 1 mice were dosed dermally or orally with 1000 mg/kg TEA, in conjunction with oral exposure to sodium nitrite. 12 Following 7 days of dermal dosing, no NDELA was detected in the blood, ingesta, or urine of test, vehicle control, or sodium nitrite control mice. (The limits of detection for the blood, ingesta, and urine were 0.001, 0.006, and 0.47 µg/mL, respectively.)…”

Section: Introductionmentioning

confidence: 99%

Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics

et al. 2013

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The Cosmetic Ingredient Review Expert Panel assessed the safety of triethanolamine (TEA) and 31 related TEA-containing ingredients as used in cosmetics. The TEA is reported to function as a surfactant or pH adjuster; the related TEA-containing ingredients included in this safety assessment are reported to function as surfactants and hair- or skin-conditioning agents. The exception is TEA-sorbate, which is reported to function as a preservative. The Panel reviewed the available animal and clinical data. Although data were not available for all the ingredients, the panel relied on the information available for TEA in conjunction with previous safety assessments of components of TEA-containing ingredients. These data could be extrapolated to support the safety of all included ingredients. The panel concluded that TEA and related TEA-containing ingredients named in this report are safe as used when formulated to be nonirritating. These ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.

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Triethanolamin [MAK Value Documentation in German language, 2010]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 48. Lieferung, Ausgabe 2010 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine

Cited by 5 publications

References 14 publications

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics

Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics

Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics

Triethanolamin [MAK Value Documentation in German language, 2010]

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