A computational fluid dynamics study is carried out on the inner nozzle flow and onset of liquid sheet instability in a large-scale pressure-swirl atomizer with asymmetric inflow configuration for high viscosity fluids. Large-eddy simulations (LES) of the two-phase flow indicate the unsteady flow character inside the nozzle and its influence on liquid sheet formation. A novel geometric volume-offluid (VOF) method by Roenby et al., termed isoAdvector, is applied for sharp interface capturing (Roenby J., Bredmose H., Jasak H., 2016, A computational method for sharp interface advection, Royal Society Open Science 3). We carry out a Reynolds number sweep (420 ≤ Re ≤ 5300) in order to investigate the link between the asymmetric inner nozzle flow and liquid sheet characteristics in laminar, transitional and fully turbulent conditions. Inside the nozzle, the numerical simulations reveal counter-rotating Dean vortices, flow impingement locations, and strong asymmetric flow features at all investigated Reynolds numbers. A helical, rotating gaseous core is observed when Re ≥ 1660. For laminar flow (Re = 420), an S-shaped liquid film is observed, while the gas core presence at Re ≥ 1660 results in a hollow cone liquid sheet. For the intermediate value Re = 830, the numerical simulations indicate a liquid sheet of mixed type.