Investigation of the intestinal microbiota in preterm infants using different methods

Rougé, Carole; Goldenberg, Oliver; Ferraris, Laurent; Berger, Bernard; Rochat, Florence; Legrand, Arnaud; Göbel, Ulf B.; Vodovar, M; Voyer, M; Rozé, Jean‐Christophe; Darmaun, Dominique; Piloquet, Hugues; Butel, Marie‐José; Cochetière, Marie-France de la

doi:10.1016/j.anaerobe.2010.06.002

Cited by 130 publications

(100 citation statements)

References 48 publications

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“…This could be because fecal samples were collected at distinct time points during the first 4 weeks of the neonate's life rather than over a long period of time (such as 2 years). In this cohort study, as reported by others (24,26), DGGE profile analysis produced findings similar to those obtained from culture studies, confirming a lower biodiversity of bacteria in infants who go on to develop NEC.…”

Section: Articles Smith Et Alsupporting

confidence: 89%

Investigation of the early intestinal microflora in premature infants with/without necrotizing enterocolitis using two different methods

et al. 2011

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Section: Articles Smith Et Alsupporting

confidence: 89%

Investigation of the early intestinal microflora in premature infants with/without necrotizing enterocolitis using two different methods

et al. 2011

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“…mode of delivery, prematurity, type of feeding (breast feeding v. formula feeding), antibiotic treatment of the child or the mother, lifestyle and geographics (65,(69)(70)(71)(72)(73)(74) . The earliest colonisers are usually facultative anaerobic bacteria such as Enterobacteriaceae, streptococci and staphylococci, whereas later colonisers tend to be strict anaerobes e.g.…”

Section: Agementioning

confidence: 99%

“…Immediately after birth, the rectal microbiota of vaginally delivered babies resembles their own mother's vaginal microbiota, whereas the rectal microbiota of babies delivered by Caesarean section resembles that of the skin (81) . The gut microbiota of preterm infants is less diverse than those of full-term babies (70,73,(82)(83)(84) . There are numerous studies in which the predominance of bifidobacteria in exclusively breast-fed infants has been found (65,66,74,(85)(86)(87)(88) .…”

Section: Agementioning

confidence: 99%

Human gut microbiota: does diet matter?

2014

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The human oro-gastrointestinal (GI) tract is a complex system, consisting of oral cavity, pharynx, oesophagus, stomach, small intestine, large intestine, rectum and anus, which all together with the accessory digestive organs constitute the digestive system. The function of the digestive system is to break down dietary constituents into small molecules and then absorb these for subsequent distribution throughout the body. Besides digestion and carbohydrate metabolism, the indigenous microbiota has an important influence on host physiological, nutritional and immunological processes, and commensal bacteria are able to modulate the expression of host genes that regulate diverse and fundamental physiological functions. The main external factors that can affect the composition of the microbial community in generally healthy adults include major dietary changes and antibiotic therapy. Changes in some selected bacterial groups have been observed due to controlled changes to the normal diet e.g. high-protein diet, high-fat diet, prebiotics, probiotics and polyphenols. More specifically, changes in the type and quantity of non-digestible carbohydrates in the human diet influence both the metabolic products formed in the lower regions of the GI tract and the bacterial populations detected in faeces. The interactions between dietary factors, gut microbiota and host metabolism are increasingly demonstrated to be important for maintaining homeostasis and health. Therefore the aim of this review is to summarise the effect of diet, and especially dietary interventions, on the human gut microbiota. Furthermore, the most important confounding factors (methodologies used and intrinsic human factors) in relation to gut microbiota analyses are elucidated.

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“…The original belief (first hypothesised at the turn of the 20 th century) that humans develop within a sterile uterine environment [24] has more recently been challenged by increasing evidence that the infants' initial inoculum can be provided by maternal transmission before birth [25]. Further evidence refuting the belief that an infant's intestine is sterile at birth comes from the recent identification of numerous microorganisms in meconium It has been suggested that the risk of developing NEC, (similar to other inflammatory bowel conditions like Chron's disease) is increased when the balance between pathogenic and commensal bacteria shifts in favour of the former resulting in an abnormal microbiome.…”

Section: The Infant Microbiomementioning

confidence: 99%