Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study

Mohany, Khalid M.; Rugaie, Osamah Al; Al‐Wutayd, Osama; Al‐Nafeesah, Abdullah

doi:10.1186/s12902-021-00829-z

Cited by 26 publications

(15 citation statements)

References 52 publications

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“…It has recently been shown in monocytes of T2DM patients that sestrin 2 plays a major role in regulating the AMPK-mTORC1-pathway [ 532 ]. Circulatory levels of sestrin 2 are significantly decreased in diabetic patients [ 533 , 534 ]. SESN2 is a target of miR-148a [ 535 ].…”

Section: Bovine Mex Mir Signaling During Adult Human Lifementioning

confidence: 99%

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Melnik

Schmitz

2022

IJMS

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Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients provided by human milk. As shown recently, exosomes derived from various origins interact with β cells. This review elucidates the potential role of milk-derived exosomes (MEX) and their microRNAs (miRs) on pancreatic β cell programming during the postnatal period of lactation as well as during continuous cow milk exposure of adult humans to bovine MEX. Mechanistic evidence suggests that MEX miRs stimulate mTORC1/c-MYC-dependent postnatal β cell proliferation and glycolysis, but attenuate β cell differentiation, mitochondrial function, and insulin synthesis and secretion. MEX miR content is negatively affected by maternal obesity, gestational diabetes, psychological stress, caesarean delivery, and is completely absent in infant formula. Weaning-related disappearance of MEX miRs may be the critical event switching β cells from proliferation to TGF-β/AMPK-mediated cell differentiation, whereas continued exposure of adult humans to bovine MEX miRs via intake of pasteurized cow milk may reverse β cell differentiation, promoting β cell de-differentiation. Whereas MEX miR signaling supports postnatal β cell proliferation (diabetes prevention), persistent bovine MEX exposure after the lactation period may de-differentiate β cells back to the postnatal phenotype (diabetes induction).

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Section: Bovine Mex Mir Signaling During Adult Human Lifementioning

confidence: 99%

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Melnik

Schmitz

2022

IJMS

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“…Previous studies from the Bruneck Study and China found that miR-122 was obviously associated with increased T2DM risk (P<0.05) (12,34). Moreover, previous studies showed that miR-122 expression level was significantly increased in patients with T2DM when compared with healthy control, and miR-122 was positively associated with FBG (P<0.05) (13,57,58). Moreover, evidence suggested that elevated circulating miR-122 was an independent risk factor for IR in young adults (OR=3.379 for 1-SD unit increase of miR-122 level, P<0.05) (56), and correlation was also observed in both the general children and those obese (r=0.586, P<0.001; r=0.442, P=0.002, respectively) (54).…”

Section: Discussionmentioning

confidence: 96%

“…In addition, 10 studies involving a total of 1,388 participants were included in the meta-analysis for correlation of miR-122 with FBG level (13,51,(53)(54)(55)(56)(57)(58)(59)(60), and the pooled result demonstrated significant positive correlation between miR-122 expression and FBG level with the random effect model (r= 0.34, 95% CI: 0.20, 0.48; Fig. 3B).…”

Section: Correlation Between Circulating Mir-126 and Mir-122 And Fbg ...mentioning

confidence: 99%

“…The heterogeneity may be due to the average age of subjects in different included study. A total of 1,190 subjects were involved in the 9 included studies in the meta-analysis for correlation of miR-122 expression with HOMA-IR index (9,16,51,(53)(54)(55)(56)58,65), and positive correlation for miR-122 and HOMA-IR index was found in the pooled result with the random effect model (r= 0.40, 95% CI: 0.16, 0.64; Fig. 4B).…”

Section: Correlation Between Circulating Mir-126 and Mir-122 And Fbg ...mentioning

confidence: 99%

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Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis

Zhai

Liu

et al. 2022

Exp Ther Med

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There are increasing numbers of studies investigating the potential link between microRNAs (miRNAs) and type 2 diabetes mellitus (T2DM) risk. Based on the prior evidence and the differentially expressed candidate plasma exosome miRNAs in our established discovery study, the current meta-analysis studied miR-126 and miR-122 specifically. The purpose of the present study was to systematically and quantitatively evaluate the relationship of miR-126 and miR-22 expression level with T2DM risk as well as related glucose metabolism parameters. Moreover, the present study was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline (PRISMA 2020 statement). PubMed, Embase, Web of Science, Cochrane and Chinese National Knowledge Infrastructure electronic databases were used to identify eligible original studies prior to May 3, 2022. The random-effects models were employed to explore the overall effect estimates [odds ratio (OR) and 95% confidence interval (CI), or correlation coefficient (r, 95% CI)].The subgroup analyses were conducted to examine the potential sources of heterogeneity. The potential publication bias was assessed by the Begg's funnel plot and Egger's tests. A total of 46 articles were included in the present meta-analysis. The results revealed that higher exposure level of miR-126 was related to lower T2DM risk in 5 analytical epidemiological studies [OR= 0.73, 95% CI: (0.55, 0.96)], lower fasting blood glucose (FBG) [N=22, r=-0.26, 95% CI: (-0.42, -0.10)], and lower homeostasis model assessment of insulin resistance (HOMA-IR) index [N=9, r=-0.28, 95% CI: (-0.52, -0.05)]. Besides, positive correlations were observed between miR-122 expression and FBG [N=10, r=0.34, 95% CI: (0.20, 0.48)], as well as HOMA-IR index [N=9, r=0.40, 95% CI: (0.16, 0.64)]. The relationship of miR-126 and miR-122 expression with T2DM risk and these glucose metabolism parameters may be influenced by study types, sample size, different source and mean age of participants. In conclusion, in the general healthy population, higher miR-126 expression was related to lower T2DM risk, FBG level and HOMA-IR index; higher miR-122 expression was closely correlated with higher FBG level and HOMA-IR index. These findings have notable clinical and public health implications for screening and control glucose metabolic disorders, insulin resistance and T2DM development.

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“…Another study showed that miR-29a overexpression disrupted adipogenesis [96]. However, miR-335, miR-218, and miR-29a levels increased with obesity [97][98][99].…”

Section: Micrornas That Promote the Osteoblastogenesis Of Bmscsmentioning

confidence: 98%

MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity

Vulf¹,

Хлусов²,

Yurova³

et al. 2022

Front. Biosci. (Schol Ed)

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Obesity and osteoporosis are global health problems characterized by high rates of prevalence and mortality due to complications. As people with visceral obesity age, the adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) increases, and adipocytes become the predominant stromal cells in the bone marrow microenvironment, which hinders the physiological regeneration and mineralization of bone tissue. Primary and secondary osteoporosis remain severe progressive diseases. Both osteoporosis and obesity are associated with microRNAs (miRNAs) that induce adipogenesis and osteoresorption. This review presents analyses of the roles and clinical potential of miRNAs in the epigenetic control of BMSC differentiation and the formation and function of osteoclasts in osteoporosis with and without obesity. Understanding the fine-tuned regulation of the expression of genes critical for the balance of osteogenesis/osteolysis processes may provide hope for the development of effective and safe osteoporosis therapies in the future.

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Investigation of the levels of circulating miR-29a, miR-122, sestrin 2 and inflammatory markers in obese children with/without type 2 diabetes: a case control study

Cited by 26 publications

References 52 publications

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis

MicroRNA Regulation of Bone Marrow Mesenchymal Stem Cells in the Development of Osteoporosis in Obesity

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