Investigation of the levels of essential and non-essential metals in women with and without abortion history: A study based on the Persian population of the Shahrekord cohort

Tousizadeh, Sepideh; Mohammadi‐Moghadam, Fazel; Sadeghi, Ramezan; Ahmadi, Ali; Shakeri, Kobra

doi:10.1016/j.chemosphere.2023.138434

Cited by 5 publications

(2 citation statements)

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“…The included articles were observational studies published between 1979 and 2023 and involved 1,377 abortion cases (including 1,159 females with SA and 218 females with RPL), together with 3,289 normal pregnant females. Of the 28 articles included in this meta-analysis, six were completed in China ( 37 , 38 , 40 , 42 , 45 , 51 ), three in Egypt ( 26 , 30 , 31 ), three in Saudi Arabia ( 29 , 36 , 47 ), three in Iran ( 48 – 50 ), two in Mexico ( 33 , 39 ), two in Turkey ( 35 , 52 ), two in Poland ( 19 , 41 ), one in Nigeria ( 27 ), one in Croatia ( 28 ), one in Italy ( 32 ), one in Australia ( 34 ), one in Serbia ( 43 ), one in India ( 44 ), and one in Russia ( 46 ). The sample size of the included studies ranged from 38 to 1,447.…”

Section: Resultsmentioning

confidence: 99%

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Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis

Ren,

Wang,

Wen

et al. 2023

Front. Endocrinol.

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ObjectiveThis study aimed to evaluate the association between blood heavy metal (zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd)) concentrations and spontaneous abortion (SA) and recurrent pregnancy loss (RPL) and explore the possible endocrine dysfunction associated with it.MethodsA literature search was performed in the PubMed, Embase, Cochrane Library, and Web of Science databases up to April 2023. The overall effects were expressed as the standard mean difference (SMD). Subgroup analysis was performed according to the type of abortion (SA or RPL). Stata 16.0 was utilized for data analysis.ResultsBased on the integrated findings, abortion women showed significantly lower Zn (SMD = −1.05, 95% CI: −1.74 to −0.36, p = 0.003) and Cu concentrations (SMD = −1.42, 95% CI: −1.97 to −0.87, p <0.001) and higher Pb (SMD = 1.47, 95% CI: 0.89–2.05, p <0.001) and Cd concentrations (SMD = 1.15, 95% CI: 0.45–1.85, p = 0.001) than normal pregnant women. Subgroup analysis showed that Zn and Cu deficiency and Cd and Pb exposure were significantly (p <0.05) associated with RPL, whereas Cu deficiency and Cd and Pb exposure were significantly (p <0.05) associated with SA.ConclusionZn and Cu deficiencies and Pb and Cd exposure were associated with abortion. Endocrine dysfunction, such as insulin resistance, vitamin D insufficiency, and abnormal thyroid and sex hormone concentrations, is thought to be involved in heavy metal-related abortion.

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Section: Resultsmentioning

confidence: 99%

“…Flow chart of the included eligible studies in systematic review and meta-analysis. Of the 28 articles included in this metaanalysis, six were completed in China(37, 38,40, 42, 45,51), three in Egypt(26,30,31), three in Saudi Arabia (29, 36, 47), three in Iran(48)(49)(50), two in Mexico (33, 39), two in Turkey (35, 52), two in Poland (19, 41), one in Nigeria…”

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confidence: 99%