Investigation of the Mechanical and Dynamic-Mechanical Properties of Electrospun Polyvinylpyrrolidone Membranes: A Design of Experiment Approach

Dodero, Andrea; Brunengo, Elisabetta; Castellano, Maila; Vicini, Silvia

doi:10.3390/polym12071524

Cited by 19 publications

(11 citation statements)

References 69 publications

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“…In particular, wound healing patches should present features similar to those of human tissues, at the same time providing integrity and stability to offer a sufficient protective capability towards the external environment [ 43 , 44 , 45 ]. In this regard, electrospun membranes are characterized by a unique mechanical behaviour, which is related to their nanofibrous structure and can be easily modulated by changing the nanofiber size and spatial organization [ 11 , 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Crosslinking Type on the Physical-Chemical Properties and Biocompatibility of Chitosan-Based Electrospun Membranes

et al. 2021

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Chitosan nanofibrous membranes are prepared via an electrospinning technique and explored as potential wound healing patches. In particular, the effect of a physical or chemical crosslinking treatment on the mat morphological, mechanical, water-related, and biological properties is deeply evaluated. The use of phosphate ions (i.e., physical crosslinking) allows us to obtain smooth and highly homogenous nanofibers with an average size of 190 nm, whereas the use of ethylene glycol diglycidyl ether (i.e., chemical crosslinking) leads to rougher, partially coalesced, and bigger nanofibers with an average dimension of 270 nm. Additionally, the physically crosslinked mats show enhanced mechanical performances, as well as greater water vapour permeability and hydrophilicity, with respect to the chemically crosslinked ones. Above all, cell adhesion and cytotoxicity experiments demonstrate that the use of phosphate ions as crosslinkers significantly improves the capability of chitosan mats to promote cell viability owing to their higher biocompatibility. Moreover, tuneable drug delivery properties are achieved for the physically crosslinked mats by a simple post-processing impregnation methodology, thereby indicating the possibility to enrich the prepared membranes with unique features. The results prove that the proposed approach may lead to the preparation of cheap, biocompatible, and efficient chitosan-based nanofibers for biomedical and pharmaceutical applications.

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Section: Resultsmentioning

confidence: 99%

Effect of Crosslinking Type on the Physical-Chemical Properties and Biocompatibility of Chitosan-Based Electrospun Membranes

et al. 2021

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“…PVP-based films were investigated as potential binders for tableting films; the mechanical properties of such films were investigated, and significant dependence of the elastic module on the humidity level was reported: from 0.93 to 0.46 GPa, for a relative humidity variation from 20% to 65% [ 72 ]. PVP fibers were also synthesized to develop fiber-oriented membranes [ 73 ], and an elastic module varying between 165 MPa and 71 MPa was reported.…”

Section: Discussionmentioning

confidence: 99%

Electrical Percolation Threshold and Size Effects in Polyvinylpyrrolidone-Oxidized Single-Wall Carbon Nanohorn Nanocomposite: The Impact for Relative Humidity Resistive Sensors Design

Serban

Cobianu

Dumbrǎvescu

et al. 2021

Sensors

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This paper reports, for the first time, on the electrical percolation threshold in oxidized carbon nanohorns (CNHox)–polyvinylpyrrolidone (PVP) films. We demonstrate—starting from the design and synthesis of the layers—how these films can be used as sensing layers for resistive relative humidity sensors. The morphology and the composition of the sensing layers are investigated through Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), and RAMAN spectroscopy. For establishing the electrical percolation thresholds of CNHox in PVP, these nanocomposite thin films were deposited on interdigitated transducer (IDT) dual-comb structures. The IDTs were processed both on a rigid Si/SiO2 substrate with a spacing of 10 µm between metal digits, and a flexible substrate (polyimide) with a spacing of 100 µm. The percolation thresholds of CNHox in the PVP matrix were equal to (0.05–0.1) wt% and 3.5 wt% when performed on 10 µm-IDT and 100 µm-IDT, respectively. The latter value agreed well with the percolation threshold value of about 4 wt% predicted by the aspect ratio of CNHox. In contrast, the former value was more than an order of magnitude lower than expected. We explained the percolation threshold value of (0.05–0.1) wt% by the increased probability of forming continuous conductive paths at much lower CNHox concentrations when the gap between electrodes is below a specific limit. The change in the nanocomposite’s longitudinal Young modulus, as a function of the concentration of oxidized carbon nanohorns in the polymer matrix, is also evaluated. Based on these results, we identified a new parameter (i.e., the inter-electrode spacing) affecting the electrical percolation threshold in micro-nano electronic devices. The electrical percolation threshold’s critical role in the resistive relative-humidity sensors’ design and functioning is clearly emphasized.

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“…[219][220][221] Additionally, electrospun NFs can be easily enriched with unique and specific functionalities in order to meet the specific requirements for the application of interest, and can be prepared in a variety of biomimetic structures. [222][223][224][225][226] For instance, electrospun mats are able to mimic the native extracellular matrix (ECM) thereby representing the ideal environment to foster cell viability allowing gas exchange and nutrient transport. [227] Also, due to the fact that drugs, NPs, and other various substances can be efficiently encapsulated within the NFs, electrospun nanomaterials find great applicability in delivery applications.…”

Section: Alginate-based Electrospun Nanofibersmentioning

confidence: 99%

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Dodero

Alberti

Gaggero

et al. 2021

Adv Materials Inter

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along with other polysaccharides (e.g., celluloses, chitosan, etc.), is indeed considered an extremely promising material in the viewpoint of circular economy and in substituting petroleum-derived polymers. [3] Among others, one of the reasons for alginate success is its unique capability to bind different cations leading to stable and tailor-made hydrogels. [4] Owing to its biocompatibility, biodegradability, and nontoxicity, in the past decades alginate has been vastly explored for drug and gene delivery, tissue engineering, and wound healing applications. [5] In this sense, the recent nanotechnological advances have allowed the fabrication and exploitation of alginate-based nanostructured materials with completely new capabilities. Thereby, it is not surprising that nowadays a broad variety of alginate-based nanomaterials with various shapes, sizes, and compositions are prepared via different approaches, including controlled gelation, electrospinning and electrospraying, self-assembly, phase-separation, and micro fluidics., All these nanostructures hold the potential to interact with living organisms much more efficiently with respect to bulk systems, hence leading to specific functionalities at the same time avoiding the occurrence of toxicity issues. [6][7][8] Despite the use of alginate-based nanomaterials has been reviewed in the past, the focus has been commonly pointed to their generic properties and applications. Conversely, this review attempts to provide a more specific and comprehensive summary limited to the most recent advances in the fabrication and use of two of the most common and promising alginatebased nanomaterials, namely nanoparticles (NPs) and electrospun nanofibers (NFs), with a focus on biomedical and pharmaceutical applications.

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Investigation of the Mechanical and Dynamic-Mechanical Properties of Electrospun Polyvinylpyrrolidone Membranes: A Design of Experiment Approach

Cited by 19 publications

References 69 publications

Effect of Crosslinking Type on the Physical-Chemical Properties and Biocompatibility of Chitosan-Based Electrospun Membranes

Effect of Crosslinking Type on the Physical-Chemical Properties and Biocompatibility of Chitosan-Based Electrospun Membranes

Electrical Percolation Threshold and Size Effects in Polyvinylpyrrolidone-Oxidized Single-Wall Carbon Nanohorn Nanocomposite: The Impact for Relative Humidity Resistive Sensors Design

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

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