Investigation of the mechanical and degradation properties of Mg–Sr and Mg–Zn–Sr alloys for use as potential biodegradable implant materials

Brar, Harpreet S.; Wong, Joey; Manuel, Michele V.

doi:10.1016/j.jmbbm.2011.07.018

Cited by 231 publications

(123 citation statements)

References 51 publications

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“…-1.0 V vs. SHE for the J1 alloy compared with -1.5 V vs. SHE for pure Mg when measured in blood plasma. Furthermore, the fine Mg 17 Sr 2 particles obtained during aging were speculated to have played a role of inducing a homogeneous corrosion [47] on the surface of the J1 alloy as opposed to highly localized, pitting, and crevice corrosion reported for other Mg alloys [25,45,48]. As a result, at the conclusion of the 16w implantation, minor localized corrosion was observed on the surface of the J1 alloy (Fig.…”

Section: Discussionmentioning

confidence: 90%

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloyIn: Acta Biomaterialia (2015) Elsevier DOI: 10.1016DOI: 10. /j.actbio.2015 An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy AbstractPrevious studies indicated that local delivery of strontium effectively increased bone quality and formation around osseointegrating implants. Therefore, implant materials with long-lasting and controllable strontium release are avidly pursued. The central objective of the present study was to investigate the in vivo biocompatibility, metabolism and osteogenic activity of the bioabsorbable Mg-1Sr (wt.%, nominal composition) alloy for bone regeneration. The general corrosion rate of the alloy implant as a femoral fracture fixation device was 0.55 ± 0.03 mm y −1 (mean value ± standard deviation) in New Zealand White rabbits which meet the bone implantation requirements and can be adjusted by material processing methods. All rabbits survived and the histological evaluation showed no abnormal physiology or diseases 16 weeks post-implantation. The degradation process of the alloy did not significantly alter 16 primary indexes of hematology, cardiac damage, inflammation, hepatic functions and metabolic process. Significant increases in peri-implant bone volume and direct bone-toimplant contact (48.3% ± 15.3% and 15.9% ± 5.6%, respectively) as well as the expressions of four osteogenesis related genes (runt-related transcription factor 2, alkaline phosphatase, osteocalcin, and collagen, type I, alpha 1) were observed after 16 weeks implantation for the Mg-1Sr group when compared to the pure Mg group. The sound osteogenic properties of the Mg-1Sr alloy by longlasting and controllable Sr release suggesting a very attractive clinical potential. Statement of significanceSr (strontium) has exhibited pronounced effects to reduce the bone fracture risk in osteoporotic patients. Nonetheless, long-lasting local Sr release is hardly achieved by traditional methods like surface treatment. Therefore, a more efficient Sr local delivery platform is in high clinical demand. The stable and adjustable degradation process of Mg alloy makes it an ideal Sr delivery platform. We combine the well-known osteogenic properties of strontium with magnesium to manufacture bioabsorbable Mg-1Sr alloy with stable Sr release based on our previous studies. The in vitro and in vivo results both showed the alloy's suitable degradation rate and biocompatibility, and the sound osteogenic properties and stimulation effect on bone formation suggest its very attractive clinical potential.

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Section: Discussionmentioning

confidence: 90%

“…It has been suggested that grain refinement induced by addition of Sr in excess of the solid solubility limit to Mg-alloys, is dictated by the grain growth restriction mechanism of secondary phase particles distributing on the advancing interface of the solid/liquid [25,45,46].…”

Section: Discussionmentioning

confidence: 99%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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“…where Ew is the equivalent weight of the corroding species in grams and ρ is the density of the corroding material in g/cm 3 .…”

Section: Electrochemical Evaluationmentioning

confidence: 99%

“…where Δg is the change in weight by grams, A is the exposed surface area of the sample in cm 2 , t is the immersion time in hours and ρ is the density in g/cm 3 .…”

Section: In Vitro Immersion Testmentioning

confidence: 99%

“…Mg is suitable for implant application in human body, for example, Mg stent, bone fixation screw, microclips in laryngeal microsurgery, bone fixation and wound-closing devices, as shown in Figure 1. Mg has many appealing properties such as light weight, high strength-to-weight ratio, good castability and osteoconductivity [3]. However, Mg has limitations mainly due to its high surface chemical reactivity resulting in high degradation rate [4].…”

Section: Introductionmentioning

confidence: 99%

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Surface Modification of Magnesium and its Alloys Using Anodization for Orthopedic Implant Application

Mousa¹,

Park²,

Kim³

2017

Magnesium Alloys

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Magnesium (Mg) as a biodegradable implant brings a revolution in medical field application, especially in bone implant and stent application. Biodegradability of Mg has attracted attentions of researchers to avoid secondary surgery to remove the implant materials after healing process. Various advantages of Mg make it suitable for medical application such as density, good mechanical properties and biodegradation. However, Mg biodegradability must be controlled to meet tissue-healing period of time because of the high degradation in a physiological environment. Fast corrosion and high alkalinity due to hydrogen release induce tissue inflammation, which limits its clinical applications. Many techniques are applied to the Mg surface to improve surface biocompatibility and control its biodegradability. This chapter focuses on anodization of Mg and its alloys to improve corrosion resistance and biocompatibility for orthopedic application. Mg coating with thin film apatite could enhance the biocompatibility and increase osseointegration formation in the bone fracture side. Evaluation of the required anodized film discussed in the chapter such as chemical composition, biodegradability and biocompatibility.

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Biodegradable Implant Materials

Öncel

Buğdaycı

2022

Biodegradable Materials and Their Applications

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Investigation of the mechanical and degradation properties of Mg–Sr and Mg–Zn–Sr alloys for use as potential biodegradable implant materials

Cited by 231 publications

References 51 publications

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

Surface Modification of Magnesium and its Alloys Using Anodization for Orthopedic Implant Application

Biodegradable Implant Materials

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