Evaluation of observable response of heat of bone cement in hip replacement was studied. In an exothermic reaction, bone cementing in a polymerization reaction between the liquid and the powder monomer, provides the bonding mechanism between the prosthesis stem and the femur cavity. This is of concern to biomechanics engineers on the mechanism of heat transfer between the femur bone, the cement and the prosthesis stem. The ANSYS software together with Autodesk software was used to model the scenario, steady state thermal structural analysis was used to simulate it. From the observation, the PMMA polymer (used as bone cement) temperature from the exothermic reaction raised the temperature in the assembly thereby creating a flow of heat amounting to 5.11x10-7W/m2 in which only 2.83x10-7 W/m2reached to the femur bone as others has been absorbed by the femur bone and prosthesis stem.0.59kJ/kg.K and 1.297kJ/kg. Kare the values of specific heat capacities of femur bone and PMMA respectively while the values of young modulus for femur bone and PMMA are 18.79GPa and 28.78GPa respectively. This result shows how possible it is to determine these properties from the studies of simulation.