Investigation of the performance of the General Electric ADVANCE positron emission tomograph in 3D mode

Lewellen, T.K.; Kohlmyer, S.G.; Miyaoka, Robert S.; Kaplan, M.S.; Stearns, C.W.; Schubert, Simone

doi:10.1109/23.531882

Cited by 126 publications

(26 citation statements)

References 7 publications

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“…The radioactivity was corrected for physical decay to the injection time. Each PET frame consisted of a 128 × 128 × 35 matrix with voxel size of 2 × 2 × 4.25 mm in a spatial resolution of 5.5 and 6.1 mm full width at half maximum (FWHM) in the radical and tangential directions, respectively, at 10 cm radius from the center of the field‐of‐view (Lewellen et al., 1996).…”

Section: Methodsmentioning

confidence: 99%

Positron Emission Tomography Imaging of Mu‐ and Delta‐Opioid Receptor Binding in Alcohol‐Dependent and Healthy Control Subjects

Weerts

Wand

Kuwabara

et al. 2011

Alcoholism Clin & Exp Res

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Background The endogenous opioid system plays a significant role in alcohol dependence. The goal of the current study was to investigate regional brain mu opioid receptor (MOR) and delta opioid receptor (DOR) availability in recently abstinent alcohol-dependent and age-matched healthy control men and women with Positron Emission Tomography (PET) imaging. Methods Alcohol dependent subjects completed an inpatient protocol, which included medically supervised withdrawal and PET imaging on day 5 of abstinence. Control subjects completed PET imaging following an overnight stay. PET scans with the MOR selective ligand [11C]carfentanil (CFN) were completed in 25 alcohol dependent and 30 control subjects. Most of these same subjects (20 alcohol dependent and 18 controls) also completed PET scans with the DOR selective ligand [11C]methyl-naltrindole (MeNTL). Results Volume of interest and statistical parametric mapping analyses indicated that alcohol dependent subjects had significantly higher [11C]CFN binding potential (BPND) than healthy controls in multiple brain regions including the ventral striatum when adjusting for age, gender and smoking status. There was an inverse relationship between [11C]CFN BPND and craving in several brain regions in alcohol dependent subjects. Groups did not differ in [11C]MeNTL BPND; however, [11C]MeNTL BPND in caudate was positively correlated with recent alcohol drinking in alcohol dependent subjects. Conclusions Our observation of higher [11C]CFN BPND in alcohol dependent subjects can result from up regulation of MOR and/or reduction in endogenous opioid peptides following long-term alcohol consumption, dependence and/or withdrawal. Alternatively, the higher [11C]CFN BPND in alcohol dependent subjects may be an etiological difference that predisposed these individuals to alcohol dependence or may have developed as a result of increased exposure to childhood adversity, stress and other environmental factors known to increase MOR. Although the direction of group differences in [11C]MeNTL BPND was similar in many brain regions, differences did not achieve statistical significance, perhaps as a result of our limited sample size. Additional research is needed to further clarify these relationships. The finding that alcohol dependent subjects had higher [11C]CFN BPND is consistent with a prominent role of the MOR in alcohol dependence.

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Section: Methodsmentioning

confidence: 99%

Positron Emission Tomography Imaging of Mu‐ and Delta‐Opioid Receptor Binding in Alcohol‐Dependent and Healthy Control Subjects

Weerts

Wand

Kuwabara

et al. 2011

Alcoholism Clin & Exp Res

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“…After correction for scattered and random coincidences, images were reconstructed onto a 128 ϫ 128 ϫ 35 matrix by a 3-dimensional reprojection algorithm by use of 4-mm transverse and 8.5-mm axial filters, resulting in a reconstructed image resolution between 5.5 and 6.5 mm in both the axial and transverse directions. 16 The tomograph, dose calibrator, and gamma counter underwent weekly cross-calibration to record all measurements in common units of radioactivity (microcuries or becquerels). At the beginning of the study, a 20-minute transmission scan for attenuation correction was acquired by use of a rotating germanium 68 source.…”

Section: Methodsmentioning

confidence: 99%

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

Sasongko

Link

Muzi

et al. 2005

Clinical Pharmacology & Therapeutics

249

271

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This is the first time that P-gp activity at the human BBB has been measured. The modest inhibition of human BBB P-gp by cyclosporine has implications for P-gp-based drug interactions at the human BBB. Our method for imaging P-gp activity can be used to identify multidrug-resistant tumors or to determine the contribution of P-gp polymorphism, inhibition, or induction to interindividual variability in drug response.

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“…The PET scans were performed with a GE Advance tomograph (General Electric, Milwaukee, W I) with the interslice septa retracted (Sadato et al, 1997). The physical characteristics of this scanner have been described in detail elsewhere (De Grado et al, 1994;Lewellen et al, 1996). This scanner acquires 35 slices with an interslice spacing of 4.25 mm.…”

Section: Pet Experimentsmentioning

confidence: 99%

Internally Simulated Movement Sensations during Motor Imagery Activate Cortical Motor Areas and the Cerebellum

Naito¹,

et al. 2002

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It has been proposed that motor imagery contains an element of sensory experiences (kinesthetic sensations), which is a substitute for the sensory feedback that would normally arise from the overt action. No evidence has been provided about whether kinesthetic sensation is centrally simulated during motor imagery. We psychophysically tested whether motor imagery of palmar flexion or dorsiflexion of the right wrist would influence the sensation of illusory palmar flexion elicited by tendon vibration. We also tested whether motor imagery of wrist movement shared the same neural substrates involving the illusory sensation elicited by the peripheral stimuli. Regional cerebral blood flow was measured with H215O and positron emission tomography in 10 right-handed subjects. The right tendon of the wrist extensor was vibrated at 83 Hz ("illusion") or at 12.5 Hz with no illusion ("vibration"). Subjects imagined doing wrist movements of alternating palmar and dorsiflexion at the same speed with the experienced illusory movements ("imagery"). A "rest" condition with eyes closed was included. We identified common active fields between the contrasts of imagery versus rest and illusion versus vibration. Motor imagery of palmar flexion psychophysically enhanced the experienced illusory angles of plamar flexion, whereas dorsiflexion imagery reduced it in the absence of overt movement. Motor imagery and the illusory sensation commonly activated the contralateral cingulate motor areas, supplementary motor area, dorsal premotor cortex, and ipsilateral cerebellum. We conclude that kinesthetic sensation associated with imagined movement is internally simulated during motor imagery by recruiting multiple motor areas.

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Investigation of the performance of the General Electric ADVANCE positron emission tomograph in 3D mode

Cited by 126 publications

References 7 publications

Positron Emission Tomography Imaging of Mu‐ and Delta‐Opioid Receptor Binding in Alcohol‐Dependent and Healthy Control Subjects

Positron Emission Tomography Imaging of Mu‐ and Delta‐Opioid Receptor Binding in Alcohol‐Dependent and Healthy Control Subjects

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

Internally Simulated Movement Sensations during Motor Imagery Activate Cortical Motor Areas and the Cerebellum

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