Investigation of the pharmacological, behavioral and biochemical effects of boron on rats with rotenone-induced Parkinson's Disease

Ozdemir, Hulya Sagmanligil; Yunusoglu, Oruç; Sağmanligil, Vedat; Yaşar, Semih; Çölçimen, Neşe; Goceroglu, RezzanTemelli; Catalkaya, Ege

doi:10.14715/cmb/2022.68.8.3

Cited by 8 publications

(7 citation statements)

References 52 publications

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“…In this case, the peripheral concentration of inflammatory protein can display the changes in the neuroinflammation of CNS. Previous literatures have shown that hs-CRP is increased in PD patients (34)(35)(36). Consistent with these studies, we also noted the increases in hs-CRP in PD patients when compared to the healthy control group.…”

Section: Comparison Of the Sensory And Motor Nerve Conduction Velocit...supporting

confidence: 92%

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Zhang¹,

Liu²,

Li³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Section: Comparison Of the Sensory And Motor Nerve Conduction Velocit...supporting

confidence: 92%

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Zhang¹,

Liu²,

Li³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…Bu miktarın yaklaşık %20'si sebze, meyve ve meyveli içecek ürünlerinden sağlanmaktadır [2]. Ayrıca, Dünya Sağlık Örgütü, yetişkinler için borun, ortalama güvenli alım düzeyinin 1-13 mg/gün olması gerektiğini bildirmiş [5,7] ancak sonrasında 0,4 mg/kg olarak güncellemiştir [6].…”

Section: Giriş (Introduction)unclassified

“…Sıçanlarda 20 mg/kg BA uygulamasının tirozin hidroksilaz (TH) aktivitesini arttırdığı ve PH patogenezinde antioksidan aktivite ile dopaminerjik sistemi koruyabileceği bildirilmiştir. Ek olarak histopatolojik ve immünhistokimyasal inceleme sonucunda nöronal dejenerasyonda azalma olduğu belirtilmiştir[7]. Yavuz ve ark.Bazı bor içeren bileşiklerin PH'daki etkileri (Effects of some boron-containing compounds on PD).Şekil 1.…”

unclassified

Alzheimer ve Parkinson Hastalıklarında Bor İçeren Bileşiklerin Nörokoruyucu Etkisi

Bitmez,

Balbal

2024

Journal of Boron

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Bu derlemede bor içeren bileşiklerin nörodejenerasyon süreci üzerindeki etkileri anlatılmaktadır. Bor içeren bileşikler nöronlar üzerinde çeşitli koruyucu etkiler gösterirler. Son araştırmalar, bor takviyesinin nöronlarda antioksidan savunma mekanizmalarının artmasına yol açtığını, inflamasyonu baskıladığını ve oksidatif hasara karşı iyi bir koruma potansiyeli sergilediğini göstermiştir. Bu doğrultuda yazılan derleme makalesinde, bor içeren bileşiklerin nöro-koruyucu etkilerinin araştırıldığı çalışmalar incelendi ve bor içeren bileşiklerin nörodejeneratif hastalıkların tedavisinde spesifik hedeflere ilaç olarak uygulanmasına ilişkin daha ileri çalışmalara gerek olduğu tespit edildi.

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“…Following oral administration, most of the levodopa is converted into dopamine in the periphery and finally, only 1 % of levodopa enters central nervous system to exert its drug effect. It, therefore, needs to be supplemented by increasing the dose [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…The disadvantage of insufficient central nervous system drug dosage, in spite of excessive oral drug dosage, easily leads to many adverse events and therapeutic effect of long-term use can gradually decline or even cause treatment fluctuations and other complications [5]. Therefore, increasing effective drug dosage in central nervous system is key to treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of ginkgo leaf tablets combined with compound carbidopa on patients with Parkinson’s disease

Huang,

Du,

Zhu

et al. 2023

Trop. J. Pharm Res

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Purpose: To determine the effect of a combination of ginkgo leaf tablets with compound carbidopa tablets on cognitive function, serum homocysteine (Hcy), malondialdehyde (MDA) and neuron-specific enolase (NSE) levels in patients with Parkinson's disease (PD).Methods: A total of eighty (80) PD patients admitted to The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China between December 2020 and December 2022 were randomly divided into two groups: Western medicine group (n = 40, using compound carbidopa tablets alone) and combination group (n = 40, using ginkgo leaf tablets combined with compound carbidopa tablets), and orally treated for 3 months. Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to assess cognitive function before and after treatment. High-performance liquid chromatography was used to determine serum Hcy levels, while enzyme-linked immunosorbent assay (ELISA) was used to evaluate serum MDA and NSE levels. Adverse reactions were also recorded during treatment.Results: Total response rate following treatment in combination group was significantly higher than in Western medicine group (95.00 vs 80.00 %, p < 0.05). After treatment, MMSE and MoCA scores in combination group were significantly higher (p < 0.05) than those in Western medicine group, while serum Hcy, MDA and NSE levels in combination group were significantly lower than those in Western medicine group (p < 0.05). During treatment, there was no significant difference in incidence of adverse reactions between the two groups (p > 0.05).Conclusion: Ginkgo leaf tablets in combination with carbidopa significantly improve cognitive functions associated with PD with high safety, when compared to carbidopa tablets alone. However, further clinical trials are commended to validate these findings.

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Investigation of the pharmacological, behavioral and biochemical effects of boron on rats with rotenone-induced Parkinson's Disease

Cited by 8 publications

References 52 publications

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Correlation between the peripheral neuropathy and levels of hs-CRP, IL-1β and IL-6 in senile Parkinson’s disease patients

Alzheimer ve Parkinson Hastalıklarında Bor İçeren Bileşiklerin Nörokoruyucu Etkisi

Effect of ginkgo leaf tablets combined with compound carbidopa on patients with Parkinson’s disease

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