Investigation of the potential anti-urolithiatic activity of Alhagi maurorum (Boiss.) grown wild in Al-Ahsa (Eastern Province), Saudi Arabia

Ammar, Rebaï Ben; Khalifa, Ashraf; Alamer, Sarah Abdulaziz; Hussain, Syed Ghazanfar; Hafez, Aly M.; Rajendran, Peramaiyan

doi:10.1590/1519-6984.259100

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…In another study by Ammar et al, in order to determine the litholytic potential of the extract, calcium oxalate urinary stones were incubated during 12 weeks under continuous shaking in the presence of AME. The results showed a significant dissolution effect of the extract on the kidney calculi during the experimentation period [ 20 ]. Although the body status is not similar to the in vitro area, this study also defines the litholytic effect of Alhagi and is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Hydroalcholic Extract of Alhagi maurorum and Hydrochlorothiazide on Excretion of 4–10 mm Kidney and Ureteral Stones in Adults: A Randomized Prospective Study

Mehrabi,

Beigi,

Salehpour

2023

Advances in Pharmacological and Pharmaceutical Sciences

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Objective. The prevalence of kidney stones and their complications is high. The review of the literature showed the therapeutic effects of Alhagi maurorum extract on urinary tract stones. This study reviewed the Alhagi plant’s hydroalcholic extract’s effect on eliminating kidney and ureteral stones compared to hydrochlorothiazide. Materials and Methods. In this randomized prospective study, from March 2019 to September 2021, 80 patients over 18 years of age with kidney stones in the upper ureter with a size of 4–10 mm were divided into two groups based on the block random allocation method. The first group received hydrochlorothiazide tablets (50 mg), and the second group received 1 gram/day of the hydroalcholic areal extract of Alhagi maurorum in a two-divided capsule. The mean size and number of stones, renal function tests, and side effects were checked and compared in both groups before and after the study. Results. Mean age, sex, serum urea level ( P = 0.351 ), serum creatinine ( P = 0.393 ), stone size ( P = 0178 ), and the number of stones ( P = 0.052 ) before intervention were similar. After intervention, the size and number of stones diminished, up to 70% in both groups. However, there was not a statistically significant difference between the two groups. Conclusion. The study showed that Alhagi maurorum is as effective as hydrochlorothiazide in treatment of kidney and ureteral stones with no significant complications and is promising.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Hydroalcholic Extract of Alhagi maurorum and Hydrochlorothiazide on Excretion of 4–10 mm Kidney and Ureteral Stones in Adults: A Randomized Prospective Study

Mehrabi,

Beigi,

Salehpour

2023

Advances in Pharmacological and Pharmaceutical Sciences

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Plant-based therapies for urolithiasis: a systematic review of clinical and preclinical studies

Allam,

Sabra

2024

Int Urol Nephrol

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In vitro Study of Litholytic Activity of Ononis natrix L. Extracts Against Calcium Oxalate Kidney Stones

Alrifaee,

Alkhantib,

Obied

2024

Scopus Indexed

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Ononis natrix is one of the wild plants from the Fabaceae family. The infusion of the plant is traditionally used for the therapy of urinary tract disorders. Urolithiasis is a deposit of stone components (oxalate, calcium, uric acid, magnesium, cysteine) in the kidneys. The formulation of stones occurs in consecutive stages. Nephrolithiasis is consecration as one of the most common Kidney diseases. Numerous phytomolecules have several functions in the management of urolithiasis. The aim was to investigate the possible litholytic effect of O. natrix extracts against calcium oxalate urinary stones. Stones were collected from urolithiasis patients after surgical procedures. The type of the stones was determined by FTIR spectroscopy, selected of calcium oxalate type, and the experiment was performed by incubating three concentrations (0.5, 1, 2) g/L of aerial parts and root extracts (ethanolic 70% and aqueous) in-vitro with physiological saline (NaCl 9 g/L) for 6 weeks. The results were presented as dissolution rate % compared to positive control (sodium citrate 3 mmol/L) and negative control (physiological saline 9 g/L). The ethanolic 70% extract of the aerial parts in the concentration of 2 g/L showed the highest litholytic activity (47.73% ± 0.66%) at the end of the experiment (week 6) followed by the concentration of 1 g/L (34.81 %± 1.25%) with statistically significant difference (P <0.0001) in comparison with sodium citrate (4.18% ± 2.13%) and physiological saline (1.37% ± 0.22%). The results exhibit that the litholytic activity of O. natrix extracts was higher in the aerial parts than the roots, it was also higher in the ethanolic extracts than the aqueous extracts, which is related to their flavonoid content.

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Investigation of the potential anti-urolithiatic activity of Alhagi maurorum (Boiss.) grown wild in Al-Ahsa (Eastern Province), Saudi Arabia

Cited by 3 publications

References 25 publications

Comparison of the Effect of Hydroalcholic Extract of Alhagi maurorum and Hydrochlorothiazide on Excretion of 4–10 mm Kidney and Ureteral Stones in Adults: A Randomized Prospective Study

Comparison of the Effect of Hydroalcholic Extract of Alhagi maurorum and Hydrochlorothiazide on Excretion of 4–10 mm Kidney and Ureteral Stones in Adults: A Randomized Prospective Study

Plant-based therapies for urolithiasis: a systematic review of clinical and preclinical studies

In vitro Study of Litholytic Activity of Ononis natrix L. Extracts Against Calcium Oxalate Kidney Stones

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