Investigation of the prevalence and clinical associations of antibodies to human fibronectin in systemic lupus erythematosus.

Atta, Mustafa S.; Lim, K L; Ala'deen, D A; Powell, R J; Todd, Ian

doi:10.1136/ard.54.2.117

Cited by 22 publications

(10 citation statements)

References 19 publications

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“…AECA directed to extracellular matrix proteins in primary systemic vasculitis have been described previously by Direskeneli [6], and the AECA binding activity could be inhibited by incubation with extracellular matrix proteins by 25% [6]. Atta et al described autoantibodies directed to FN in sera of patients with SLE using FN as antigen [26,27]. In contrast we found VN-and FN-containing IC in the sera of CSS, WG, and also SLE patients, but in none of the sera we found uncomplexed autoantibodies able to bind to the FN or VN proteins themselves.…”

Section: Discussionmentioning

confidence: 92%

Vitronectin- and Fibronectin-containing Immune Complexes in Primary Systemic Vasculitis

Maehnss

Kobarg

Schmitt

et al. 2002

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 92%

Vitronectin- and Fibronectin-containing Immune Complexes in Primary Systemic Vasculitis

Maehnss

Kobarg

Schmitt

et al. 2002

Journal of Autoimmunity

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“…AFA can be detected by enzyme-linked immunosorbent assay (ELISA) using pure fibrinogen (e.g., bovine) as the antigen source or by sandwich ELISA using mouse monoclonal antihuman fibronectin antibodies to capture fibronectin from a commercial product [1,9]. In immunoblotting, AFA detection is limited by low sensitivity, probably due to denaturation of the antigen.…”

Section: Methods Of Detectionmentioning

confidence: 99%

Fibronectin Autoantibodies

Feist

Hiepe

2014

Autoantibodies

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“…As an example, antibodies against fibronectin, a glycoprotein vastly present in the plasma and tissue in two main isoforms, but also "trapped" in basement membranes, occur in primary systemic vasculitis, a disease mainly characterized by anti-endothelial cell auto-antibodies [44]. Additionally, anti-fibronectin antibodies were reported in systemic lupus erythematosus [45], another example of connective tissue diseases. It should be mentioned however, that in these cases, these antibodies are secondary, and the primary antigens for antibody formation in these auto-…”

Section: Other Anti-basement Membrane-related Autoimmunitymentioning

confidence: 97%

Basement Membrane Peptides: Functional Considerations and Biomedical Applications in Autoimmunity

Charonis¹,

Sideraki²,

Kaltezioti³

et al. 2005

CMC

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Basement membranes are specialized extracellular matrices that surround certain cell types (muscle cells, adipose cells, etc) and are present under the basal surface of cells exhibiting polarity (epithelial, endothelial and mesothelial cells). They have a unique macromolecular composition, consisting mainly of type IV collagen isoforms, laminin isoforms, entactin/nidogen, and perlecan. These components self associate and interact with each other to form networks. Other macromolecules may be found in specialized basement membranes. In this short review, the role of selected basement membrane proteins in autoimmune diseases will be highlighted. As an example, Goodpasture's syndrome will be presented and the relatively long quest for identification of the antigenic epitope on specific domains of the alpha3(IV)NC1 will be summarized. Chagas disease will be discussed as an example of laminin-mediated autoimmunity, with emphasis on the role of sugar-based antigenic epitope(s) will be presented. Immune-mediated tubulointerstitial nephritis will be introduced and the role of a synthetic peptide in detecting proximal tubule damage in acute renal failure will be discussed. Auto-immune diseases where other basement membrane macromolecules are involved will be mentioned. Finally, the importance of understanding the functions served by domains at close proximity to the antigenic epitope(s) will be highlighted.

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Investigation of the prevalence and clinical associations of antibodies to human fibronectin in systemic lupus erythematosus.

Abstract: Objectives-To assess the prevalence of antibodies to human fibronectin (anti-Fn) in sera of patients with certain connective tissue diseases and to determine their association with disease activity and the pattern of organ involvement in patients with systemic lupus erythematosus (SLE).

Cited by 22 publications

References 19 publications

Vitronectin- and Fibronectin-containing Immune Complexes in Primary Systemic Vasculitis

Vitronectin- and Fibronectin-containing Immune Complexes in Primary Systemic Vasculitis

Fibronectin Autoantibodies

Basement Membrane Peptides: Functional Considerations and Biomedical Applications in Autoimmunity

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