Investigation of the Prevalence of Diminished Ovarian Reserve in Korean Women of Reproductive Age

Abstract

Diminished ovarian reserve can be assessed biochemically using serum anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) tests. This study aimed to evaluate the prevalence of diminished ovarian reserve in a large population of reproductive-aged women by age and geographic region in Korea using different cutoffs of serum AMH and FSH levels. In 2022, 13,351 women underwent both AMH and FSH tests. The prevalence of diminished ovarian reserve increased markedly with age. Although cutoffs for AMH and FSH levels are different in USA and Korean guidelines, the overall prevalence of diminished ovarian reserve was comparable. The maximum prevalence was 3.8%, 6.0%, 11.0%, 28.6%, 69.3%, and 95.0% in women aged 20–24, 25–29, 30–34, 35–39, 40–44, and 45–49 years, respectively. The overall prevalence and age-adjusted prevalence of diminished ovarian reserve were 37.2% and 38.4%, respectively. Women who had only increased serum FSH without decreased AMH represented 1.1% (by Korean guidelines) and 2.5% (by USA guidelines) of all women. Serum AMH and FSH tests were underutilized on Jeju Island. The results of this study provide basic knowledge about diminished ovarian reserve for use in infertility support programs and the field of maternal aging.

Evaluation of Serum Anti-Müllerian Hormone (AMH) Values for 28,016 Bulgarian Women: Prognostic Statistical Model of Age Specific AMH Declining

“…Other studies have also analyzed the percentage of cases with low AMH levels. Authors [32] [37] analyzing the prevalence of cases with reduced ovarian reserve according to the criteria of the American College of Obstetrics and Gynecology (ACOG) and the American Society for Reproductive Medicine (ASRM), found that the relative percentage of women with AMH < 1 ng/mL and Comparing our results with the studies mentioned above, we find that between the ages of 20 -29, the percentage of cases with low levels is similar. In the age groups between 30 -39 years, the percentage of women with AMH < 1 ng/ml Open Journal of Obstetrics and Gynecology is relatively higher in the Bulgarian ethnic group.…”

Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

“…Owing to the deleterious impact of environmental pollution, psychological stress, and unhealthy lifestyles, infertility has witnessed a marked uptick in recent years and emerged as a pressing global health issue [ 1 , 2 , 3 , 4 ]. In a recent report published by the World Health Organization in 2022, it was estimated that the global prevalence of infertility stands at 17.5%, with the Western Pacific region exhibiting the highest rates, peaking at 23.2% [ 5 , 6 ]. Over the past two decades, China has witnessed a rise in infertility rates among those of reproductive age from 2.5–3.0% to 12.5–18.0% [ 7 , 8 ].…”