Investigation of the protective effect of acetazolamide and SLC-0111 on carbon tetrachloride-induced toxicity in fruit fly

Güneş, Eda; Aydın, Hasan Emre; Nizamlıoğlu, Hatice Ferhan

doi:10.1016/j.toxrep.2021.06.014

Cited by 7 publications

(6 citation statements)

References 42 publications

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“…The laboratory conditions to maintain the colony were 25°C–30°C and 55 ± 5% relative humidity with some minor modifications. [ 35–37 ]…”

Section: Methodsmentioning

confidence: 99%

“…The laboratory conditions to maintain the colony were 25°C-30°C and 55 ± 5% relative humidity with some minor modifications. [35][36][37] In the study, seven serial dilutions were prepared from each of the AH1-12 chemical compounds from 1/2 to 1/128. All chemical compounds were dissolved in DMSO and diluted with the same solution.…”

Section: Larvicidal Activitymentioning

confidence: 99%

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In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents

Aydın

Akocak

Lolak

et al. 2023

J Biochem & Molecular Tox

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Multidrug resistance (MDR) causes difficulties in the treatment of infections and cancer. Research and development studies have become increasingly important for the strategy of preventing MDR. There is a need for new multitarget drug research and advancement to reduce the development of drug resistance in drug‐drug interactions and reduce cost and toxic effects. This study aimed to determine the effects of multi‐target triazene compounds on antibacterial, antifungal, antiviral, cytotoxic, and larvicidal activities were investigated in vitro. A series of 12 novel of 1,3‐diaryltriazene‐substituted sulfadiazine (SDZ) derivatives were synthesized, and the obtained pure products characterized in detail by spectroscopic and analytic methods (FT‐IR, 1H‐NMR, 13C‐NMR, and melting points). The antibacterial and antifungal activities of these derivatives (AH1‐12) were determined by broth microdilution method. All derivatives have been evaluated in cell‐based assays for cytotoxic and antiviral activities against Modified Vaccinia Virus Ankara. The larvicidal efficacy of these chemical compounds was also investigated by using Lucilia sericata (L. sericata) larvae. Twelve 1,3‐diaryltriazene‐substituted SDZ derivatives (AH1‐12) were designed and developed as potent multitargeted compounds. Among them, the AH1 derivative showed the most antibacterial and antifungal activity. Besides, synthesized derivatives AH2, AH3, AH5, and AH7 showed higher antiviral activity than SDZ. All synthesized derivatives showed higher cytotoxic activity than SDZ. Also, they showed larvicidal activity at 72 h of the experiment. As a result, these compounds might be great leads for the development of next‐generation multitargeted agents.

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“…The laboratory conditions to maintain the colony were 25°C–30°C and 55 ± 5% relative humidity with some minor modifications. [ 35–37 ]…”

Section: Methodsmentioning

confidence: 99%

Section: Larvicidal Activitymentioning

confidence: 99%

In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents

Aydın

Akocak

Lolak

et al. 2023

J Biochem & Molecular Tox

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“…L. sericata was reared in a 12 m 2 room under laboratory conditions of 25°C-30°C and 50 ± 5% relative humidity (RH) in a particular light source. [32][33][34][35][36] Adults were fed on sucrose and water, but larvae were reared on chicken liver-agar medium recommended by Mumcuoğlu, [33] Uslu, [34] Aydın & Uslu, [35] and Uslu et al [36]…”

Section: Insect Culturementioning

confidence: 99%

Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis‐sulfonamide Schiff base compounds

Aydın

Akocak

Lolak

et al. 2023

J Biochem & Molecular Tox

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Schiff bases (imines or azomethines) are versatile ligands synthesized from the condensation of amino compounds with active carbonyl groups and used for many pharmaceutical and medicinal applications. In our study, we aimed to determine the cytotoxic, antifungal and larvicidal activities of biologically potent bis‐sulfonamide Schiff base derivatives that were re‐synthesized by us. For this aim, 16 compounds were re‐synthesized and tested for their cytotoxic, antifungal and larvicidal properties. Among this series, compounds A1B2, A1B4, A4B2, A4B3, and A4B4 were shown to have cytotoxic activity against tested cancer lung cell line (A549). The most potent antifungal activity was observed in compounds A2B1 and A2B2 against all fungi. A1B1 showed the strongest larvicidal effect at all concentrations at the 72nd h (100% mortality). These obtained results demonstrate that these type of bis‐substituted compounds might be used as biologically potent pharmacophores against different types of diseases.

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“…[22][23][24] The ureido benzenesulfonamide SLC-0111 (Figure 1), as the first selective CA IX/XII inhibitor, is currently in Phase I/II clinical trials for the treatment of advanced, metastatic hypoxic tumors. [25][26][27] Therefore, the design of high affinity, isozymeselective inhibitors devoid of causing side effects due to off-target CA modulation would be a fruitful and effective strategy for the development of potent therapeutic agents. [2] Literature survey highlights that 1,2,3-triazole-based heterocyclic scaffolds possess a wide array of pharmacological activities including antimicrobial, [28] antiproliferative, [29] antitubercular, [30] anti-HIV, [31] antibacterial, [32] anticancer, [33] and so on.…”

Section: Introductionmentioning

confidence: 99%

“…[ 22–24 ] The ureido benzenesulfonamide SLC‐0111 (Figure 1), as the first selective CA IX/XII inhibitor, is currently in Phase I/II clinical trials for the treatment of advanced, metastatic hypoxic tumors. [ 25–27 ] Therefore, the design of high affinity, isozyme‐selective inhibitors devoid of causing side effects due to off‐target CA modulation would be a fruitful and effective strategy for the development of potent therapeutic agents. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Benzenesulfonamides with trisubstituted triazole motif as selective carbonic anhydrase I, II, IV, and IX inhibitors

Sharma

Kumar

Angeli

et al. 2022

Archiv der Pharmazie

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Twenty novel 1,2,3-triazole benzenesulfonamides featuring nitrile 8a-g, carbothioamide 9a-f, and N′-hydroxycarboximidamide 10a-g functionalities were designed and synthesized to improve potency and selectivity as carbonic anhydrase inhibitors (CAIs). The synthesized 1,2,3-triazole compounds were tested in vitro as CAIs against four physiologically and pharmacologically relevant isoforms of human carbonic anhydrase (hCA I, II, IV, and IX). Compounds 8a-g, 9a-f, and 10a-g displayed variable inhibition constants ranging from 8.1 nM to 3.22 μM for hCA I, 4.7 nM to 0.50 μM for hCA II, 15.0 nM to 3.7 μM for hCA IV, and 29.6 nM to 0.27 μM for hCA IX. As per the inhibition data profile, compounds 9a-e exhibited strong efficacy for hCA IV, whereas the inhibition was found to be somewhat

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Investigation of the protective effect of acetazolamide and SLC-0111 on carbon tetrachloride-induced toxicity in fruit fly

Cited by 7 publications

References 42 publications

In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents

In vitro multitarget activity of sulfadiazine substituted triazenes as antimicrobial, cytotoxic, and larvicidal agents

Evaluation of cytotoxic, antifungal, and larvicidal activities of different bis‐sulfonamide Schiff base compounds

Benzenesulfonamides with trisubstituted triazole motif as selective carbonic anhydrase I, II, IV, and IX inhibitors

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