Investigation of the quality of the drug Enalapril commercialized by pharmacies of manipulation in Belo Horizonte, Brazil

Leal, Alexandre Soares; Menezes, M. A. B. C.; Jačimović, Radojko; Sepe, Fernanda Peixoto; Gomes, Tatiana Cristina Bomfim

doi:10.1007/s10967-014-3073-6

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…Three studies assessed enalapril quality- two from Brazil [ 46 , 47 ] and one from Turkey [ 48 ]. One of the Brazilian studies (2011; 20 samples) reported 100% of samples were substandard due to failure to meet Brazilian Pharmacopoeia API specification [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…The study from Turkey reported that all eight samples met the criteria of API content and friability, however, all samples failed in the hardness test [ 48 ]. The other Brazilian study (2014) detected contaminants (including aluminium, gold, bromine, cerium, cobalt, hafnium, lanthanum, antimony, scandium, samarium, thorium, zinc, chromium) in all five samples [ 47 ]. Only one study on the quality of hydralazine was identified, conducted in the USA in which 12 (75.0%) samples were found to be poor-quality due to presence of impurities resulting from degradation i.e.…”

Section: Resultsmentioning

confidence: 99%

“…(five studies) (see Table 4) [30][31][32][33][34], and antihypertensive medicines-amlodipine (seven studies), nifedipine (two studies), methyldopa (three studies), enalapril (three studies) and hydralazine (one study) (see Table 5) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. No study assessing quality of labetalol was identified.…”

Section: Plos Global Public Healthmentioning

confidence: 99%

“…We found 15 studies on the quality of antihypertensives (Table 5) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Seven studies evaluated the quality of amlodipine-two studies from India and Nepal found no evidence of poorquality amlodipine [36,38].…”

Section: Antihypertensive Medicinesmentioning

confidence: 99%

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The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

Maharjan,

Ponganam,

Lambert

et al. 2024

PLOS Glob Public Health

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The quality of medicines for the prevention and management of hypertensive disorders of pregnancy globally is a critical challenge in the reduction of maternal mortality rate. We aimed to conduct a systematic review of available studies on the quality of the eight medicines recommended globally for the prevention and management of hypertensive disorders of pregnancy. We searched five electronic databases- Ovid MEDLINE, EMBASE, CINAHL, ProQuest and Cochrane Library, and also grey literature, without year or language limitations. Any study assessing the quality parameters (Active Pharmaceutical Ingredients, pH, sterility, solubility, impurities) of medicines by using any valid laboratory methods was eligible. Two reviewers independently screened the studies, extracted data and applied Medicine Quality Assessment Reporting Guidelines tool for quality assessment. Results were narratively reported and stratified by the drug types. Of 5669 citations screened, 33 studies from 27 countries were included. Five studies reported on the quality of magnesium sulphate—two (Nigeria and USA) found substandard medicine due to failing API specification and contaminants, respectively. Another study from Nigeria and a multi-country study (10 lower-middle- and low-income countries) found poor-quality due to failing the pH criteria. Seven of eight studies evaluating aspirin found quality issues, including degraded medicines in five studies (Brazil, USA, Yugoslavia and Pakistan). Five studies of calcium supplements found quality issues, particularly heavy metal contamination. Of 15 antihypertensives quality studies, 12 found substandard medicines and one study identified counterfeit medicines. This systematic review identified pervasive issues of poor-quality medicines across all recommended medicines used to prevent or treat hypertensive disorders of pregnancy, raising concerns regarding their safety and effectiveness.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Plos Global Public Healthmentioning

confidence: 99%

Section: Antihypertensive Medicinesmentioning

confidence: 99%

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The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

Maharjan,

Ponganam,

Lambert

et al. 2024

PLOS Glob Public Health

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“…The dead time was lower than 3 %. More details about the reactor and gamma spectra analysis can be found at [24].…”

Section: Irradiation and Characterization Of The Complexmentioning

confidence: 99%

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

Leal¹,

Marzano

Pereira-Maia

et al. 2016

J Radioanal Nucl Chem

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The proposal of this work was to investigate the effect of the radioactive complex of platinum(II) with tetracycline, [PtCl 2 (C 22 H 24 N 2 O 8 )]*, or [Tc-Pt(II)]*, on K562 cells-blood human cells of leukemia-and verify if the internal radio-chemotherapy would be able to produce additional effects compared with the non-labelled complex, [PtCl 2 (C 22 H 24 N 2 O 8 )], or [Tc-Pt(II)]. The concentration required to inhibit 50 % of cellular growth, (IC 50 ), was 2.5 ± 0.2 lM for [Tc-Pt(II)]* and 14.5 ± 0.9 lM for the non-labelled molecule [Tc-Pt(II)]. This result suggest that the [Tc-Pt(II)]* could be a potent radiosensitizer evoking a supra additive effect. Treatment using the internal radiochemotherapy may be a useful alternative to reduce the drug concentration required for effective inhibition of the tumor growth.

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k0-Neutron Activation Analysis at CDTN, Brazil: 27 years of history, development and main achievements

Menezes

Sabino

Jačimović

2023

J Radioanal Nucl Chem

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Investigation of the quality of the drug Enalapril commercialized by pharmacies of manipulation in Belo Horizonte, Brazil

Cited by 4 publications

References 12 publications

The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline

k0-Neutron Activation Analysis at CDTN, Brazil: 27 years of history, development and main achievements

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