Investigation of the relationship between ergocristinine and vascular receptors

Cherewyk, Jensen E; Blakley, Barry; Al-Dissi, Ahmad

doi:10.1016/j.toxrep.2023.05.005

Toxicology Reports

2023

DOI: 10.1016/j.toxrep.2023.05.005

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Investigation of the relationship between ergocristinine and vascular receptors

Jensen E Cherewyk

Barry Blakley

Ahmad Al-Dissi

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Cited by 2 publications

References 63 publications

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The C-8-S-isomers of ergot alkaloids — a review of biological and analytical aspects

Cherewyk,

Blakley,

Al-Dissi

2023

Mycotoxin Res

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Ergot alkaloids are secondary metabolites that are produced by fungi and contaminate cereal crops and grasses. The ergot alkaloids produced by Claviceps purpurea are the most abundant worldwide. The metabolites exist in two configurations, the C-8-R-isomer (R-epimer) and the C-8-S-isomer (S-epimer). These two configurations can interconvert to one another. Ergot alkaloids cause toxic effects after consumption of ergot-contaminated food and feed at various concentrations. For bioactivity reasons, the C-8-R-isomers have been studied to a greater extent than the C-8-S-isomer since the C-8-S-isomers were considered biologically inactive. However, recent studies suggest the contrary. Analytical assessment of ergot alkaloids now includes the C-8-S-isomers and high concentrations of specific C-8-S-isomers have been identified. The inclusion of the C-8-S-isomer in regulatory standards is reviewed. This review has identified that further research into the C-8-S-isomers of ergot alkaloids is warranted. In addition, the inclusion of the C-8-S-isomers into regulatory recommendations worldwide for food and feed should be implemented. The objectives of this review are to provide an overview of historic and current studies that have assessed the C-8-S-isomers. Specifically, this review will compare the C-8-R-isomers to the C-8-S-isomers with an emphasis on the biological activity and analytical assessment.

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The C-8-S-isomers of ergot alkaloids — a review of biological and analytical aspects

Cherewyk,

Blakley,

Al-Dissi

2023

Mycotoxin Res

View full text Add to dashboard Cite

show abstract

Exploring the antimitotic, thrombolytic, and cytotoxic properties of lasiosiphon glaucus or gnidia glauca (fresen.) gilg leaf alkaloid extract: insights from experimental and in silico investigations

Valleti,

Kumar,

Ramayanam

et al. 2024

Natural Product Research

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Investigation of the relationship between ergocristinine and vascular receptors

Cited by 2 publications

References 63 publications

The C-8-S-isomers of ergot alkaloids — a review of biological and analytical aspects

The C-8-S-isomers of ergot alkaloids — a review of biological and analytical aspects

Exploring the antimitotic, thrombolytic, and cytotoxic properties of lasiosiphon glaucus or gnidia glauca (fresen.) gilg leaf alkaloid extract: insights from experimental and in silico investigations

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