Investigation of the relationship between schizophrenia and toxoplasmosis in Van province, Turkey

Evaluation of Toxoplasma gondii in the Etiology of Cryptogenic Epilepsy: A Case-control Study

“…5 Studies conducted in Turkey in the last decade have determined T. gondii seropositivity to be 26.8-32.4% in the general population. 7 T. gondii seropositivity was found to be 29% in the control group of a study investigating the relationship between schizophrenia and toxoplasmosis in Van province, 6 and 28% in the control group of a study investigating T. gondii seropositivity in hemodialysis patients. 8 This study also showed 28.66% positivity in individuals without any neurological disease selected as the control group.…”

“…Studies have reported that T. gondii with an increasing prevalence recently may be associated with some neurological disorders such as Parkinson's disease, Alzheimer's disease, schizophrenia, and epilepsy. 3,4,6 While there is consistency in the results of studies on schizophrenia, 5 there is no clear information about the role of T. gondii in the etiology of neurological disorders such as epilepsy. There are studies reporting that there is no statistically significant difference between the T. gondii seropositivity rate of epileptic patients and that of the healthy control group, 9,10 as well as studies reporting that the seropositivity rate is higher in epileptic patients.…”

“…5 Based on these studies, the T. gondii positivity rate was reported to be higher in patients with various neuropsychiatric disorders, such as schizophrenia, CE, bipolar disorder, obsessive-compulsive disorder, unipolar depression, substance use disorder, suicides, murders, generalized anxiety disorder and panic disorder, personality disorders, and mood disorders, than in healthy controls. 3,4,6 Current studies consistently support the relationship between T. gondii and schizophrenia, although it is necessary to conduct more detailed studies on other disorders. 5 Content of this journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.…”

Toxoplasmosis and Schizophrenia Publication Activity in 1991-2023: A Web of Science-Based Bibliometric Analysis

“…In addition to research on geneenvironment interaction and environment-environment interaction, the establishment of a polygenic risk score for this disease has significantly improved the understanding of this disease [5]. According to recent epidemiologic studies, some schizophrenia cases may be caused by infectious diseases [7,8]. Perinatal infections, such as toxoplasmosis, syphilis, Rubella, Herpes Simplex Virus, and others cause neuropsychiatric disorders including mental retardation, difficulty with learning, sensorineural issues, and neuromorphological deficiencies [9].…”