Investigation of the relaxing effect of a camphor nanoemulsion on rat isolated trachea

Freitas, Maíra M.; Cavalcante, Pedro M.; Duarte-Filho, Luiz A.M.S.; Macêdo, Cícero André Ferreira; Brito, Mariana Coelho; Menezes, Pedro Modesto Nascimento; Ribeiro, Thiago F.; Costa, Sâmara M.; Carvalho, Bárbara A.G.; Ribeiro, Fernanda P R A; Moura, Marigilson P.S.; Silva, Fabrício Souza; Ribeiro, Luciano Augusto de Araújo

doi:10.1016/j.cbi.2021.109656

Cited by 5 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The action of camphor at these receptors likely accounts for its analgesic activities. In addition, activation of the TRPV family of receptors has been linked to the ability of camphor to relax the trachea in rats, which may help explain its anti-congestive activities [ 160 ].…”

Section: Mechanism Of Action For Terpenes—pharmacologic Receptor Targ...mentioning

confidence: 99%

Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy

et al. 2022

View full text Add to dashboard Cite

Cannabis is a complex biosynthetic plant, with a long history of medicinal use. While cannabinoids have received the majority of the attention for their psychoactive and pharmacological activities, cannabis produces a diverse array of phytochemicals, such as terpenes. These compounds are known to play a role in the aroma and flavor of cannabis but are potent biologically active molecules that exert effects on infectious as well as chronic diseases. Furthermore, terpenes have the potential to play important roles, such as synergistic and/or entourage compounds that modulate the activity of the cannabinoids. This review highlights the diversity and bioactivities of terpenes in cannabis, especially minor or secondary terpenes that are less concentrated in cannabis on a by-mass basis. We also explore the question of the entourage effect in cannabis, which studies to date have supported or refuted the concept of synergy in cannabis, and where synergy experimentation is headed, to better understand the interplay between phytochemicals within Cannabis sativa L.

show abstract

Section: Mechanism Of Action For Terpenes—pharmacologic Receptor Targ...mentioning

confidence: 99%

Secondary Terpenes in Cannabis sativa L.: Synthesis and Synergy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In China, the incidence of asthma in young children is high [ 3 ]. Asthma is one of the most common chronic diseases in the world, and its incidence is increasing worldwide, bringing a high economic burden to society [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of global gene expression using RNA-sequencing reveals novel mechanism of Yanghe Pingchuan decoction in the treatment of asthma

Pan,

He,

Gong

et al. 2024

BMC Pulm Med

View full text Add to dashboard Cite

Background Yanghe Pingchuan decoction (YPD) has been used for asthma treatment for many years in China. We sought to understand the mechanism of YPD, and find more potential targets for YPD-based treatment of asthma. Methods An ovalbumin-induced asthma model in rats was created. Staining (hematoxylin and eosin, Masson) was used to evaluate the treatment effect of YPD. RNA-sequencing was carried out to analyze global gene expression, and differentially expressed genes (DEGs) were identified. Analysis of the functional enrichment of genes was done using the Gene Ontology database (GO). Analysis of signaling-pathway enrichment of genes was done using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Real-time reverse transcription-quantitative polymerase chain reaction was undertaken to measure expression of DEGs. Results Pathology showed that YPD had an improvement effect on rats with asthma. RNA-sequencing showed that YPD led to upregulated and downregulated expression of many genes. The YPD-based control of asthma pathogenesis may be related to calcium ion (Ca2+) binding, inorganic cation transmembrane transporter activity, microtubule motor activity, and control of canonical signaling (e.g., peroxisome proliferator-activated receptor, calcium, cyclic adenosine monophosphate). Enrichment analyses suggested that asthma pathogenesis may be related to Ca2 + binding and contraction of vascular smooth muscle. A validation experiment showed that YPD could reduce the Ca2 + concentration by inhibiting the Angiopoietin-II (Ang-II)/Phospholipase (PLA)/calmodulin (CaM0 signaling axis. Conclusion Control of asthma pathogenesis by YPD may be related to inhibition of the Ang-II/PLA/CaM signaling axis, reduction of the Ca2+ concentration, and relaxation of airway smooth muscle (ASM).

show abstract