Investigation of the role of nitric oxide driven angiogenesis by zinc oxide nanoflowers

Barui, Ayan Kumar; Nethi, Susheel Kumar; Patra, Chitta Ranjan

doi:10.1039/c6tb03323g

Cited by 38 publications

(75 citation statements)

References 50 publications

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“…Thus, two cell types relevant for wound healing can be promoted in their viability simultaneously using ZnO NPs. For endothelial cells, these findings are in line with findings of Barui et al, who also described an increase in cellular viability in HUVECs by treatment with ZnO nanoflowers [44]. Additionally, the stimulatory influence of ZnO NPs on fibroblasts were previously described by Augustine et al [23,45], even though the pure substance alone was not investigated in this study.…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies described pro-angiogenic [22,23,[44][45][46] as well as anti-angiogenic [47][48][49][50] properties for ZnO NPs, indicating that the corresponding characteristics are strongly dependent on the type of nanoparticles and the environmental conditions. The importance of mild reactive oxygen species generation for the formation of blood vessels is well known [51].…”

Section: Discussionmentioning

confidence: 97%

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Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

et al. 2021

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Due to the demographic change, medicine faces a growing demand for tissue engineering solutions and implants. Often, satisfying tissue regeneration is difficult to achieve especially when co-morbidities hamper the healing process. As a novel strategy, we propose the incorporation of zinc oxide nanoparticles (ZnO NPs) into biomaterials to improve tissue regeneration. Due to their wide range of biocompatibility and their antibacterial properties, ZnO NPs are already discussed for different medical applications. As there are versatile possibilities of modifying their form, size, and function, they are becoming increasingly attractive for tissue engineering. In our study, in addition to antibacterial effects of ZnO NPs, we show for the first time that ZnO NPs can foster the metabolic activity of fibroblasts as well as endothelial cells, both cell types being crucial for successful implant integration. With the gelatin sponge method performed on the chicken embryo’s chorioallantoic membrane (CAM), we furthermore confirmed the high biocompatibility of ZnO NPs. In summary, we found ZnO NPs to have very favorable properties for the modification of biomaterials. Here, incorporation of ZnO NPs could help to guide the tissue reaction and promote complication-free healing.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

et al. 2021

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“…[ 109 ] The capability of NO in angiogenesis has also been confirmed by other studies. [ 110 ] Collectively, precise delivery of NO holds great promises in treating ischemic heart diseases such as myocardium infraction. [ 111 ]…”

Section: The Biomedical Applications Of Polymeric No Delivery Nanoplamentioning

confidence: 99%

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.

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“…Another example studied the signaling pathway of ZnO-mediated angiogenesis (Fig. 16C&D) [132]. It was found that ROS produced by ZnO induced Akt/MAPK/eNOS pathway which further led to production of nitric oxide and cGMP-dependent angiogenesis.…”

Section: Other Ions or Element (Sr Mg Zn Ti And Ce)mentioning

confidence: 99%

“…The silicate-based biominerals have also been produced into composites or hybrids for bone tissue engineering. Recently, 2D [132]. (E) Cerium oxide nanoparticles (CNPs) varying Ce 3+ / Ce 4+ ratios (CNPl; Ce 3+ dominant, CNPll; Ce 4+ dominant) accelerated angiogenesis in vivo (especially Ce 3+ dominant CNP).…”

Section: Silicatementioning

confidence: 99%

Materials roles for promoting angiogenesis in tissue regeneration

Lee

Parthiban

Jin

et al. 2021

Progress in Materials Science

114

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Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of tissueengineered constructs. Although many biochemical signaling molecules have been used, their biological functions in vivo are known to be limited, mainly due to their short lifetime and poor activity. Matrices (or engineered biomaterials), beyond the biochemical signals, play pivotal roles in stimulating angiogenic processes. Here we discuss the proangiogenic effort taken to repair and regenerate various tissues including skin, bone, muscle and nerve, focusing on the roles of engineered matrices. This includes the design of pore structure and physico-chemical properties (nanotopology, stiffness, chemistry and degradability), the tailoring of matrices for proper presentation of growth factors and their crosstalks with adhesion ligands, the controlled and sustained delivery of angiogenic molecules and metallic ions, and the engineering of cells and construction of prevascularized tissues. Collectively, the materials-driven strategies are envisaged

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Investigation of the role of nitric oxide driven angiogenesis by zinc oxide nanoflowers

Abstract: Zinc oxide nanoflowers (ZONF) induce the generation of intracellular ROS that stimulates the phosphorylation of Akt and p38MAPK leading to activation of eNOS to produce NO, triggering angiogenesis in a cGMP dependent manner.

Cited by 38 publications

References 50 publications

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Materials roles for promoting angiogenesis in tissue regeneration

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