Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma

Zhang, G; Bai, Rong; Zhang, T; Zhang, H; Sz, Wen; Jiang, DM

doi:10.4238/2015.july.27.16

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Sensitivity analysis (Figure 3B for the dominant model) was conducted and the results were stable on the whole. Cumulative analysis (Figure 3C for dominant model) demonstrated a significant protective association from the study of Zhang et al in 2015 [32]. No publication bias was found in the funnel plot and Egger's test (C vs. G, P = 0.80; CC vs. GG, P = 0.55; GC+CC vs. GG, P = 0.61; CC vs. GG+GC, P = 0.19) (Figure 3D for the dominant model).…”

Section: Resultsmentioning

confidence: 92%

“…For the +936C/T polymorphism, the seven studies included a total of 1,350 cases and 1,706 controls [27, 30–35]. For the +1612 G/A polymorphism, the six studies included a total of 1,166 cases and 1,524 controls [27, 30–32, 34, 35]. For the −634 G/C polymorphism, the six studies involved a total of 1,166 cases and 1,524 controls [27, 30–32, 34, 35].…”

Section: Resultsmentioning

confidence: 99%

“…For the +1612 G/A polymorphism, the six studies included a total of 1,166 cases and 1,524 controls [27, 30–32, 34, 35]. For the −634 G/C polymorphism, the six studies involved a total of 1,166 cases and 1,524 controls [27, 30–32, 34, 35]. All the included case-control studies used the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.…”

Section: Resultsmentioning

confidence: 99%

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Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility

Du²,

Zhan

et al. 2016

Oncotarget

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Polymorphisms in the vascular endothelial growth factor (VEGF) gene may contribute to osteosarcoma risk, but the results of previous studies have been inconsistent and inconclusive. We conducted a meta-analysis to assess this association more accurately. Relevant studies were collected systemically from three online English databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations of three VEGF gene polymorphisms (+936C/T, '634 G/C, +1612 G/A) with osteosarcoma risk. Seven case-control studies involving 1,350 cases and 1,706 controls were selected for the meta-analysis. The pooled OR indicated that the VEGF +936C/T polymorphism was associated with increased risk of osteosarcoma in a Chinese population (T vs. C: OR = 1.26, 95% CI = 1.12–1.42, P < 0.01; TT vs. CC: OR = 1.70, 95% CI = 1.29–2.24, P < 0.01; CT + TT vs. CC: OR = 1.23, 95% CI = 1.06–1.44, P < 0.01; TT vs. CC + CT: OR = 1.61, 95% CI = 1.23–2.10, P < 0.01). A significant association was also found between the −634 G/C polymorphism and osteosarcoma risk (C vs. G: OR = 0.81, 95% CI = 0.69-0.96, P = 0.01; CC vs. GG: OR = 0.66, 95% CI = 0.48–0.90, P < 0.01; GC + CC vs. GG: OR = 0.80, 95% CI = 0.67–0.96, P = 0.02; CC vs. GG + GC: OR = 0.72, 95% CI = 0.60–0.86, P < 0.01). In sum, our meta-analysis suggests VEGF polymorphisms are associated with osteosarcoma susceptibility in the Chinese population. However, further studies that include different ethnicities and larger populations are needed.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility

Du²,

Zhan

et al. 2016

Oncotarget

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“…; Zhang et al . ,b; Zhao et al . ) consisted of 1220 cases and 1576 controls met the inclusion criteria, and all of studies were conducted in Chinese Han population.…”

Section: Resultsmentioning

confidence: 99%

The associations of vascular endothelial growth factor gene polymorphisms with susceptibility to osteosarcoma: evidence from a meta-analysis

Zhao

Chen

et al. 2016

Eur J Cancer Care

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Several studies have investigated the associations of the vascular endothelial growth factor (VEGF) gene polymorphisms with the susceptibility to osteosarcoma, while their conclusions are conflicting. This meta-analysis was performed to provide a comprehensive assessment on those associations. Electronic bibliographic databases were searched for potential studies focused on the relationship between VEGF polymorphisms and the susceptibility to osteosarcoma on 10 December 2015. Pooled odds ratios with 95% confidence intervals were conducted to assess the associations. After strict screening process, six articles consisted of 1220 osteosarcoma patients and 1576 controls were selected. The pooled results suggested that VEGF-2578C/A polymorphism was significantly associated with osteosarcoma risk in all genetic models as well as VEGF-634G/C polymorphism. When it came to VEGF+936C/T polymorphism, we detected significant associations under allele contrast, heterozygote, dominant and recessive models. As to VEFG-460T/C polymorphism, significant associations were demonstrated in allele contrast and heterozygote models. With regard to VEGF-1156G/A polymorphism, significant association was observed only in alleles contrast model. However, there was no significant association between VEGF-1612G/A polymorphism and risk of osteosarcoma. This meta-analysis suggests that these polymorphisms comprised of VEGF-2578C/A, VEGF-1156G/A, VEGF+936C/T, VEGF-634G/C and VEGF-460T/C are associated with osteosarcoma risk in Chinese Han population.

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“…Not all people exposed to similar risk factors develop osteosarcoma, however, which suggests that hereditary factors may influence susceptibility. Several previous studies have reported that gene polymorphisms play an important role in osteosarcoma, including variations in VEGF, FGF2, GSTs, NFKB1, RECQL5 and CTLA-4 genes (He et al, 2014;Zhi et al, 2014;Han et al, 2015;Li et al, 2015;Zhang et al, 2015;Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 98%

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Guo¹,

Hc²,

Shi³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects were included in our study. The XRCC3 Thr241Met polymorphism was analyzed using a polymerase chain reaction restriction fragment length polymorphism assay. By multiple logistic regression analysis, individuals carrying the Met/Met genotype of XRCC3 Thr241Met were at significantly increased risk of osteosarcoma when compared with the Thr/Thr (OR = 2.50, 95%CI = 1.13-5.66). The Thr/Met+Met/Met genotype of XRCC3 Thr241Met was furthermore found to be correlated with an elevated increased risk of osteosarcoma when compared with the Thr/Thr genotype (OR = 1.71, 95%CI = 1.03-2.87), and Met/Met genotype of XRCC3 Thr241Met was associated with an increased risk of osteosarcoma compared to the Thr/ Thr (OR = 3.50, 95%CI = 1. 51-8.79). In conclusion, our study firstly reports 16485 XRCC3 Thr241Met polymorphism and osteosarcoma risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16484-16490 (2015) that XRCC3 Thr241Met gene polymorphism is associated with an elavated risk of osteosarcoma.

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Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma

Cited by 8 publications

References 32 publications

Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility

Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility

The associations of vascular endothelial growth factor gene polymorphisms with susceptibility to osteosarcoma: evidence from a meta-analysis

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

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