In this study, the experiment conditions for the variation of heat release rate in compartment space were constructed to analyze the effects of fire spread and the operation time of sprinkler in accordance with the heat loss of the sprinkler's heat element. The compartment composed of fire board (width = 0.3 m, height = 0.5 m, length = 3.0 m), are manufactured to measure the temperature distributions in the inner space, the mass loss rate and heat release rate during the experiment of N-heptane pool fire test. Also, the operation time of sprinkler is analyzed with the installation of sprinkler and C-factor using Fire Dynamics Simulator Ver.6 under the experiment conditions. The results show that the operation time of sprinkler, which has RTI 100 (m•s) 0.5 operating temperature 70 ℃,