Investigation of the TLR4 and IRF3 signaling pathway-mediated effects of monensin in colorectal cancer cells

Seçme, Mücahit; Koçoğlu, Sema Serter

doi:10.1007/s12032-023-02055-0

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…The expression of biglycan (BGN), a TLR4 ligand, is elevated in cancers, contributing to the epigenetic silencing of siglec-7 ligands through the BGN/TLR4/NF-κB pathway in CRC cells [ 70 ]. TLRs initiate the activation of NF-κB and IRFs, determining the nature and effectiveness of innate immune responses [ 71 ]. Epithelial TLR4 activation is associated with increased dual oxidase 2 and NADPH oxidase 1 in IBD and CRC, impacting mucosal microbiota and promoting colitis-associated tumors [ 72 ].…”

Section: Tlr4 Pathway-related Biochemical Processesmentioning

confidence: 99%

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The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Luo,

Zhang,

et al. 2024

Molecules

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The toll-like receptor 4 (TLR4) signaling pathway constitutes an intricate network of protein interactions primarily involved in inflammation and cancer. This pathway triggers intracellular signaling cascades, modulating transcription factors that regulate gene expression related to immunity and malignancy. Previous studies showed that colon cancer patients with low TLR4 expression exhibit extended survival times and the TLR4 signaling pathway holds a significant role in CRC pathogenesis. In recent years, traditional Chinese medicines (TCMs) have garnered substantial attention as an alternative therapeutic modality for CRC, primarily due to their multifaceted composition and ability to target multiple pathways. Emerging evidence indicates that specific TCM products, such as andrographolide, rosmarinic acid, baicalin, etc., have the potential to impede CRC development through the TLR4 signaling pathway. Here, we review the role and biochemical processes of the TLR4 signaling pathway in CRC, and natural products from TCMs affecting the TLR4 pathway. This review sheds light on potential treatment strategies utilizing natural TLR4 inhibitors for CRC, which contributes to the advancement of research and accelerates their clinical integration into CRC treatment.

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Section: Tlr4 Pathway-related Biochemical Processesmentioning

confidence: 99%

“…TLRs initiate the activation of NF-κB and IRFs, determining the nature and effectiveness of innate immune responses [71]. Epithelial TLR4 activation is associated with increased dual oxidase 2 and NADPH oxidase 1 in IBD and CRC, impacting mucosal microbiota and promoting colitis-associated tumors [72].…”

Section: Inflammation and Immunizationmentioning

confidence: 99%