Investigation of the toxicity effects of bisphenol A (BPA) on the renal function and blood parameter of the laboratory rate

Abstract

This study was conducted at the College of Science, University of Al-Qadisiyah, to study the relationship between the toxic environmental effects of BPA compound and some biochemical components on the blood of female and male rats, in this study, 60 male and female rats were used, They ranged in age from 8 to 12 weeks, and their weights ranged from 145-200 grams for females and 85-150 grams for males. Rats were divided into four groups according to the dose, with males and females separated. Two control groups: these two groups, three females and three males, dosed 5.0 ml/kg body weight of corn oil per day, group A. Nine females and nine males were fed BPA orally (every day after dissolving in corn oil at 50 mg./kg body weight). Group III (B): 9 females and 9 males were given BPA orally (every day with corn oil, 100 mg/kg body weight). In group C, nine females and nine males were orally injected with a dose of 200 mg/kg BPA dissolved in corn oil every day. The experiment lasted three months. After the end of the first month of animal adaptation, animals were dosed orally for 2 weeks daily.