Investigation of the μ‐ and κ‐opioid receptor activation by eight new synthetic opioids using the [³⁵S]‐GTPγS assay: U‐47700, isopropyl U‐47700, U‐49900, U‐47931E, N‐methyl U‐47931E, U‐51754, U‐48520, and U‐48800

Abstract

In 2009, new synthetic opioids appeared on the new psychoactive substances market. This class of new psychoactive substances generally poses a health risk due to the high affinity and potency of most of these compounds for the opioid receptors. It is known that overdoses can lead to respiratory depression and result in death. However, for many new synthetic opioids, data on toxicological and toxicokinetic properties are scarce. In the present study, eight U-opioids were investigated for their structure activity relationships at the μand κ-opioid receptors using a [ 35 S]-GTPγS

Interpol Review of Drug Analysis 2019-2022

“…2019 determination of ocfentanil and W-18 in a heroin-like powder using LC-DAD and GC-MS for screening and confirmation by LC-TQMS [ 712 ]; multicomponent computational approach to assess the structural and pharmacological similarity of newly identified drugs of abuse to controlled substances with focus on newly emerging illicit opioids [ 713 ]; Traceable Opioid Material Kits which provides over 150 opioid reference standards, including over 100 fentanyl analogues [ 714 ]; Liquid chromatography-chemiluminescence nitrogen detection (LC-CLND) for quantification of seized synthetic opioids [ 715 ]; review on the chemistry and pharmacology of synthetic opioids on the illicit drug market [ 716 ]; SERS method for detection of trace amounts of opioids on clothing and packages [ 717 ]; 2020 Open Port Interface Mass Spectrometry (OPI-MS) method for detection of opioids on mail and packaging materials [ 718 ]; 2021 sensor for detection of opiate drugs in pharmaceutical, clinical and forensic applications [ 719 ]; chemiluminescence method coupled with flow injection for determination of nalbuphine hydrochloride in pharmaceutical formulations [ 720 ]; analytical method for the simultaneous determination of a broad range of opioids in wastewater [ 721 ]; detection of carfentanil and etizolam in opioid samples acquired at a drug checking service using a portable GC-MS [ 722 ]; wastewater analysis of opioids [ 723 ]; pipette-tip-RSPE of seven opioid analgesics (morphine, codeine, oxycodone, tramadol, nalbuphine, thebaine, and noscapine) followed by HPLC-UV analysis [ 724 ]; a SERS method for the detection of trace levels of opioids (fentanyl, hydrocodone, oxycodone, and tramadol) in suspect tablets using two different handheld Raman spectrometers equipped with 785 and 1064 nm lasers [ 725 ]; CV to examine the transfer of the protonated forms of several natural and synthetic opioids including fentanyl and its analogues, morphine, heroin and codeine [ 726 ]; LC-QTOF-MS/MS and NMR spectroscopy for the identification and structural characterization of synthetic opioids (3,4-methylenedioxy-U-47700 and four fentanyl analogues:o-methyl-acetylfentanyl, benzoylfentanyl, 2-thiophenefentanyl and benzoylbenzylfentanyl) [ 727 ]; development of a targeted GC-MS method for the confirmation of synthetic opioids and related compounds [ 728 ]; SERS method for detection of opioids [ 729 ]; 2022 LCMS analysis of methylenedioxy U-47700, ethylenedioxy U-47700, ethylenedioxy U-51754, U-69593, U-47931E (bromadoline), U-47700, U-48800, U-49900, U-51754, U-50488, propyl U-47700 and isopropyl U-47700 [ 730 ]; investigation of the structure activity relationships at the mu- and kappa-opioid receptors of eight U-opioids (U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800) using a [S-35]-GTP gamma S assay [ 731 ]; assessment of opioid surrogates for colorimetric testing [ ...…”