Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus

Niu, Hong; Mu, Haibo; Zhang, Wuxia; Sun, Feifei; Duan, Jinyou

doi:10.1016/j.ijbiomac.2016.01.111

Cited by 56 publications

(26 citation statements)

References 50 publications

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“…Additionally, oral treatment of chickens with I. obliquus fermentation products during vaccination improved peripheral blood mononuclear cells and the ratio of Th1/Th2 and suppressed the virulence of Newcastle disease virus (Zhang et al, ). Furthermore, in vitro studies in RAW 264.7 macrophages showed that lignin complexes from I. obliquus stimulated phagocytic activity, scavenged 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radicals, and enhanced the production of NO (Niu et al, ).…”

Section: Influence Of I Obliquus Extract On the Immune Systemmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane-type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested.

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Section: Influence Of I Obliquus Extract On the Immune Systemmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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show abstract

“…However, Soares et al (2012) reported that coniferyl aldehyde could be produced by degradation of lignin. Niu et al (2016) reported that chaga mushroom water extract has lignin-carbohydrate complexes. Therefore, coniferyl aldehyde might exist in the chaga mushroom extracts of the present study.…”

Section: Identification Of Phenolic Compoundsmentioning

confidence: 99%

Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction

Hwang

Yang

Kim

et al. 2019

LWT

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Chaga mushroom (Inonotus obliquus) has been known to have antioxidant, anti-virus, anti-inflammatory, and anti-tumor effects due to its bioactive compounds such as β-glucans, triterpenoids, phenolic compounds, and melanin complexes. This mushroom has been used as a folk remedy since the 16th century and mainly consumed as extracted. Hot water extraction, which is a traditional method preparing chaga mushroom extract, has limitations requiring a large amount of solvent and long extraction time, resulting in degradation and coagulation of bioactive compounds. The objective of this study was to develop efficient methods extracting bioactive compounds in chaga mushroom, compared with hot water extraction. High II temperature and pressure, enzyme, and ultrasound extractions were used as non-traditional extraction methods. Chaga mushroom extracts were prepared under conditions determined by preliminary experiments. β-Glucans were higher in high temperature and pressure and enzyme extracts than in hot water extract. Total triterpenoids were higher in the enzyme and ultrasound extracts than in the hot water extract. Total phenolic compounds were higher in the high temperature and pressure extract than in the hot water extract. Major phenolic compounds in the chaga mushroom extracts, which were identified by HPLC, LC-MS, and GC-MS, were 3,4-dihydroxybenzaldehyde and coniferyl aldehyde, which were the highest in the high temperature and pressure and enzyme extracts, respectively. Antioxidant activities were the highest in the high temperature and pressure extract which had the highest content of phenolic compounds. In conclusion, high temperature and pressure and enzyme extractions may be efficient methods to produce chaga mushroom extracts with a large amount of bioactive compounds.

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“…Inonotus oblique is a white rot fungus that belongs to the family Hymenochaetaceae (of Basidiomycetes) that is widely distributed in Russia, North America, Europe, Japan and northeastern China [ 5 ]; it has been used as an edible mushroom without any adverse side effects in treatment of cancers and digestive system diseases [ 6 , 7 ]. In recent years, it has been reported that Inonotus obliquus extracts have various biological activities, such as anti-inflammatory, anti-nociceptive and anti-hyperglycemic properties [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice

Chou

Chang

Peng

et al. 2016

IJMS

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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in diabetes mellitus. Oxidative stress, insulin resistance and pro-inflammatory cytokines have been shown to play an important role in pathogeneses of renal damage on type 2 diabetes mellitus (DM). Inonotus obliquus (IO) is a white rot fungus that belongs to the family Hymenochaetaceae; it has been used as an edible mushroom and exhibits many biological activities including anti-tumor, anti-oxidant, anti-inflammatory and anti-hyperglycemic properties. Especially the water-soluble Inonotus obliquus polysaccharides (IOPs) have been previously reported to significantly inhibit LPS-induced inflammatory cytokines in mice and protect from streptozotocin (STZ)-induced diabetic rats. In order to identify the nephroprotective effects of low molecular weight of IOP fraction (LIOP), from the fruiting bodies of Inonotus obliquus, high-fat diet (HFD) plus STZ-induced type 2-like diabetic nephropathy C57BL/6 mice were investigated in this study. Our data showed that eight weeks of administration of 10-100 kDa, LIOP (300 mg/kg) had progressively increased their sensitivity to glucose (less insulin tolerance), reduced triglyceride levels, elevated the HDL/LDL ratio and decreased urinary albumin/creatinine ratio(ACR) compared to the control group. By pathological and immunohistochemical examinations, it was indicated that LIOP can restore the integrity of the glomerular capsules and increase the numbers of glomerular mesangial cells, associated with decreased expression of TGF-β on renal cortex in mice. Consistently, three days of LIOP (100 µg/mL) incubation also provided protection against STZ + AGEs-induced glucotoxicity in renal tubular cells (LLC-PK1), while the levels of NF-κB and TGF-β expression significantly decreased in a dose-dependent manner. Our findings demonstrate that LIOP treatment could ameliorate glucolipotoxicity-induced renal fibrosis, possibly partly via the inhibition of NF-κB/TGF-β1 signaling pathway in diabetic nephropathy mice.

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Investigation of three lignin complexes with antioxidant and immunological capacities from Inonotus obliquus

Cited by 56 publications

References 50 publications

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Effects of non-traditional extraction methods on extracting bioactive compounds from chaga mushroom (Inonotus obliquus) compared with hot water extraction

Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice

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